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排序方式: 共有2412条查询结果,搜索用时 15 毫秒
71.
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David J. Whellan Pierluigi Tricoci Edmond Chen Zhen Huang David Leibowitz Pascal Vranckx Gregary D. Marhefka Claes Held Jose C. Nicolau Robert F. Storey Witold Ruzyllo Kurt Huber Peter Sinnaeve A. Teddy Weiss Jean-Pierre Dery David J. Moliterno Frans Van de Werf Philip E. Aylward Harvey D. White Paul W. Armstrong Lars Wallentin John Strony Robert A. Harrington Kenneth W. Mahaffey 《Journal of the American College of Cardiology》2014
73.
Salgado-Galicia Norma Alicia Hernández-Doño Susana Ruiz-Gómez Daniela Jakez-Ocampo Juan Zúñiga Joaquín Vargas-Alarcón Gilberto Acuña Víctor Hernández María Teresa Márquez-García José Eduardo García-Lechuga Maricela Llorente Luis Lima Guadalupe Pineda Carlos Yu Neng Yunis Edmond Granados Julio 《Clinical rheumatology》2020,39(7):2151-2161
Clinical Rheumatology - Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disorder for which Major Histocompatibility Complex (MHC) genes are well-identified as risk factors. SLE... 相似文献
74.
Ofer Cohen Adva Mechaly Tamar Sabo Ron Alcalay Ronit Aloni-Grinstein Nehama Seliger Chanoch Kronman Ohad Mazor 《Clinical and Vaccine Immunology : CVI》2014,21(11):1534-1540
Ricin, one of the most potent and lethal toxins known, is classified by the Centers for Disease Control and Prevention (CDC) as a select agent. Currently, there is no available antidote against ricin exposure, and the most promising therapy is based on neutralizing antibodies elicited by active vaccination or that are given passively. The aim of this study was to characterize the repertoire of anti-ricin antibodies generated in rabbits immunized with ricin toxoid. These anti-ricin antibodies exhibit an exceptionally high avidity (thiocyanate-based avidity index, 9 M) toward ricin and an apparent affinity of 1 nM. Utilizing a novel tissue culture-based assay that enables the determination of ricin activity within a short time period, we found that the anti-ricin antibodies also possess a very high neutralizing titer. In line with these findings, these antibodies conferred mice with full protection against pulmonary ricinosis when administered as a passive vaccination. Epitope mapping analysis using phage display random peptide libraries revealed that the polyclonal serum contains four immunodominant epitopes, three of which are located on the A subunit and one on the B subunit of ricin. Only two of the four epitopes were found to have a significant role in ricin neutralization. To the best of our knowledge, this is the first work that characterizes these immunological aspects of the polyclonal response to ricin holotoxin-based vaccination. These findings provide useful information and a possible strategy for the development and design of an improved ricin holotoxin-based vaccine. 相似文献
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Arterial access site and outcomes in patients undergoing percutaneous coronary intervention with and without vorapaxar 下载免费PDF全文
Jean‐Pierre Déry MD MHS Kenneth W. Mahaffey MD Pierluigi Tricoci MD PhD Harvey D. White DSC Mohua Podder PhD Cynthia M. Westerhout PhD David J. Moliterno MD Robert A. Harrington MD Edmond Chen MD John Strony MD Frans Van de Werf MD Khaled M. Ziada MD Claes Held MD PhD Philip E. Aylward MD Paul W. Armstrong MD Sunil V. Rao MD 《Catheterization and cardiovascular interventions》2016,88(2):163-173
77.
Risks and side effects of islet transplantation 总被引:3,自引:0,他引:3
Islet transplantation can deliver stable glycemic control, relief from recurrent severe hypoglycemia, and insulin independence.
Accessing the portal vein via the percutaneous hepatic approach carries the risk of bleeding, and the infusion of islets a
risk of portal vein thrombosis. In the long term, common minor problems with immunosuppression are mouth ulcers, diarrhea,
and acne. Longer-term risks include malignancy and serious infection, both rare to date in clinical islet transplantation.
Sensitization to donor antigens may also occur. The long-term diabetes complications may stabilize, but of this aspect little
is known to date. In the short term, there may be some elevation of serum cholesterol and blood pressure, in some patients
there has been a decline in renal function, and in a few, acute retinal bleeds. For most, improvement in glucose control with
resolution of glycemic lability and hypoglycemia has been a net benefit. 相似文献
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Recently, one of the world’s leading scientific and technical advisory groups, the U.S. President’s Council of Advisors on Science and Technology (or PCAST), published an assessment of the research supporting several forensic science procedures in regular use. PCAST was particularly interested in pattern recognition or comparison procedures, specifically: simple and mixed DNA profiles; bite marks; latent fingerprints; firearms; footwear; and hair analysis. In its report and recommendations PCAST emphasised the primacy of validation. In response, the Council of the Australian and New Zealand Forensic Science Society produced a short statement suggesting that the PCAST report has limited application to forensic science in Australia and New Zealand. This short commentary offers an alternative perspective. 相似文献
80.
Uniparental disomy 7 in Silver--Russell syndrome and primordial growth retardation 总被引:12,自引:2,他引:12
Kotzot Dieter; Schmitt Silke; Bernasconi Fabiana; Robinson Wendy P.; Lurie Iosif W.; Ilyina Helena; Mehes Karoly; Hamel Ben C.J.; Otten Barto J.; Hergersberg Martin; Werder Edmond; Schoenle Eugen; Schinzel Albert 《Human molecular genetics》1995,4(4):583-587
Maternal uniparental disomy for the entire chromosome 7 hasso far been reported in three patients with intrauterine andpostnatal growth retardation. Two were detected because theywere homozygous for a cystic fibrosis mutation for which onlythe mother was heterozygous, and one because he was homozygousfor a rare COL1A2 mutation. We investigated 35 patients witheither the Silver-Russell syndrome or primordial growth retardationand their parents with PCR markers to search for uniparentaldisomy 7. Four of 35 patients were found to have maternal disomy,including three with isodisomy and one with heterodisomy. Thedata confirm the hypothetical localization of a maternally imprintedgene (or more than one such gene) on chromosome 7. It is suggestedto search for UPD 7 in families with an offspring with sporadicSilver-Russell syndrome or primordial growth retardation. 相似文献