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排序方式: 共有440条查询结果,搜索用时 15 毫秒
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THOMAS G. COONEY M.D. DONALD C. BAUER M.D. C. MICHAEL KNAUER M.D. 《The American journal of gastroenterology》1980,74(5):436-438
Portal hypertension associated with hepatocellular carcinoma in the absence of cirrhosis of the liver has not been clearly recognized in the past. While the incidence of this association is unknown, its occurrence does not appear to be rare. This case report describes a 49-year old male with hepatocellular carcinoma, ascites and measured portal hypertension but no cirrhosis of the liver. The portal hypertension was secondary to microscopic invasion of central veins and small portal veins. Hepatocellular carcinoma in the absence of cirrhosis should be added to the differential diagnosis of portal hypertension. 相似文献
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F. E. BAUER M. A. GHATEI A. ZINTEL S. R. BLOOM 《Alimentary pharmacology & therapeutics》1989,3(6):591-596
Galanin was infused intravenously into eight healthy volunteers at a dose of 40 pmol kg-1 min-1 for 1 h to investigate the pharmacological effects of this peptide on the postprandial sialagogical response in man. Galanin significantly increased the salivary volume and the saliva output of sodium, chloride and bicarbonate compared to control saline infusion, but had no effect on the output of potassium and alpha-amylase. An increase in salivary pH was also observed. The increase in salivary volume may indicate a physiological role of galanin in the control of salivary secretion. 相似文献
436.
P.C.M. VAN DE KERKHOF F.W. BAUER R.M.MAASSEN-DE GROOD 《The British journal of dermatology》1985,113(3):251a-255a
The penetration of polymorphonuclear leukocytes (PMNs) into the epidermis following topical application of leukotriene B4 was assessed in the clinically uninvolved skin of psoriatic patients treated with methotrexate and of psoriatic patients without treatment, and in normal controls. Inhibition of PMN infiltration was observed in those patients treated with methotrexate while there was no significant difference between untreated psoriatic patients and normal controls. 相似文献
437.
Flow cytometry as a tool for the study of cell kinetics in skin 2. Cell kinetic data in psoriasis 总被引:2,自引:0,他引:2
F.W. BAUER N.H.C.M.N. CROMBAG J.B.M. BOEZEMAN R.M.DE GROOD 《The British journal of dermatology》1981,104(3):271-276
Flow cytometry was used to measure the DNA content of epidermal keratinocytes from psoriatic patients. Gross deviations were found in the lesions and minor but significant changes in the uninvolved skin. Statistical analysis revealed that the rather large variation in the DNA distributions of the lesions was due to inter-individual differences rather than to inter-individual differences. The duration of the S-phase seemed to be prolonged in the lesion, but the length of the overall cell cycle might be of the same order as that of normal skin. 相似文献
438.
Clinical cardiac electrophysiologic evaluation of the positive inotropic agent, DPI 201-106 总被引:1,自引:0,他引:1
BUTROUS G. S.; DEBBAS N. M. G.; ERWIN J.; DAVIES D. W.; KELLER H. P.; LUNNON M. W.; NATHAN A. W.; CAMM A. J. 《European heart journal》1988,9(5):489-497
DPI 201106 is a new positive inotropic agent. The cardiacelectrophysiology of 16 patients was studied before and duringDPI 201106 administration (loading dose of intravenousDPI 201106, 1·8 mg kg1 h1 administeredover 10 min, followed by a maintenance dose of 0·2 mgkg1 h1). DPI 201106 had no effect on thesinus node. The AH interval during fixed-rate atrial pacingbecame prolonged during DPI 201106 infusion. There wasa significant prolongation of the QT interval [QT (corrected),417 ± 22 to 502 ± 35 ms, P<0·05; QT(atrial pacing at 600 ms), 374 ±17 to 419 ± 23ms, P<0·05; QT (ventricular pacing at 600 ms), 409± 37 to 449 ± 30 ms, P<0·05]. The ventriculareffective refractory period significantly prolonged during DPI201106 administration (242 ± 21 to 287 ±56 ms, P < 0·05), but the supernormal-period durationdecreased. The atrial effective refractory period was shortenedin four patients and prolonged in one (261 ± 67 to 240± 53 ms, NS). The corrected atrial repolarization time(PTac) shortened significantly during DPI 210106 infusion(479 ± 26 to 445 ± 22 ms at 20 min of the maintenancedose, P<0·05). Atrial fibrillation was initiated infive patients during DPI infusion, but no ventricular arrhythmiawas provoked. These findings suggest that DPI 201106has novel differential electrophysiological effects on atriaand ventricles. 相似文献
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LARS LICKFETT M.D. ERICA MITTMANN‐BRAUN M.D. CHRISTIAN WEISS M.D. SEBASTIAN SPENCKER M.D. WERNER JUNG M.D. WILHELM HAVERKAMP M.D. STEPHAN WILLEMS M.D. THOMAS DENEKE M.D. JOSEF KAUTZNER M.D. MICHAEL WIEDEMANN M.D. JÜRGEN SIEBELS M.D. HEINZ F. PITSCHNER M.D. ELLEN HOFFMANN M.D. GERD HINDRICKS M.D. MARKUS ZABEL M.D. ERNST VESTER M.D. HARALD SCHWACKE M.D. JOHANNES V. LEYEN Ph.D. CHRISTIAN MEWIS M.D. WOLFGANG BAUER M.D. THORSTEN LEWALTER M.D. 《Pacing and clinical electrophysiology : PACE》2013,36(2):194-202