Reduction of Metacholine-Induced Nasal Secretion by Treatment with a New Topical Steroid in Perennial Non-Allergic Rhinitis

The value of three objective tests of the nasal mucosa in 22 patients with perennial non-allergic rhinitis treated with a topical corticosteroid has been investigated. Placebo and three different dosages of a new steroid, budesonide, were administered intranasally using a double-blind, cross-over technique. Nasal airway resistance was not reduced by the steroid treatment as compared with the placebo treatment. Eosinophilia in nasal smears was reduced by budesonide. However, the value of this test was decreased by the fact that eosinophilia was found in less than 50% of the patients at the beginning of the trial. Metacholine-induced nasal secretion was significantly reduced by the budesonide treatment. Symptom scores for nasal obstruction, secretion and sneezing attacks were also significantly reduced by the steroid.     

Number of teeth, prevalence of caries and periapical lesions in insulin-dependent diabetics

Abstract – Ninety-four long and 86 short duration diabetics and 86 non-diabetics, aged 20–70 yr, participated in the study. The clinical and radiographic examination comprised recordings of the number of teeth, carious lesions, restorations, endodontically treated teeth and periapical lesions. There were no significant differences between long and short duration diabetics and non-diabetics in the number of teeth and the total number of decayed and filled tooth surfaces (DFS %). However, long duration diabetics exhibited more decayed proximal tooth surfaces (D %) than non-diabetics. There were no significant differences between long and short duration diabetics and non-diabetics in the mean number of endodontically treated teeth and periapical lesions. Women with long diabetes duration, however, exhibited more endodontically treated teeth with periapical lesions than women with short diabetes duration and women without diabetes. Long duration diabetics exhibited teeth with periapical lesions to a greater extent than the other groups. On the whole, diabetics and non-diabetics exhibited a similar caries frequency but among the diabetics there was a group of individuals who had more periapical lesions than the non-diabetics.     

A polarized light and scanning electron microscope study of the effect of Duraphat treatment on in vivo caries

Abstract – The present study was carried out to examine the effect of application of a fluoride varnish (Duraphat) on experimentally produced caries in vivo. After a 4-wk period of cariogenic challenge on homologous pairs of premolars, Duraphat was applied on one of the teeth while the other was extracted and saved as a control. The Daraphat treated teeth remained in a cariogenic environment for a new period of 2 wk prior to extraction. All the control teeth displayed the classical characteristics of active incipient subsurface carious lesions. The Duraphat treated lesions showed an increase in surface porosity relative to their controls while the subsurface porosity was dramatically reduced. When examined in the SEM, the corresponding surface appeared smooth with a leveling out of the original surface irregularities. High power microscopy disclosed, however, a distinct network of intercrystalline spaces. Application of Duraphat prior to reestablishment of cariogenic challenge apparently gives rise to a marked redistribution of minerals in active initial carious lesions.     

Human monocytes cultured with and without interferon-gamma inhibit Plasmodium falciparum parasite growth in vitro via secretion of reactive nitrogen intermediates

Adherent cells from human peripheral blood were studied for their interaction with asexual blood forms of Plasmodium falciparum in vitro. Freshly isolated monocytes only showed weak anti-parasitic effects. However, an enhancement of this anti-parasitic activity was apparent when monocytes were allowed to mature in vitro. Monocytes activated with IFN-γ for two or three days had an enhanced anti-parasitic effect. In contrast, the inhibition mediated by cells incubated for five days was the same with or without IFN-γ treatment. There was no evidence of toxicity when IFN-γ at high concentrations was added directly to P. falciparum cultures. The anti-parasitic activity of the activated cells seemed to be due to nitric oxide since incubation of macrophages with L-NMMA reduced the level of inhibition. However, inhibition was only partial suggesting that other factors also were involved in inhibition of parasite growth.     

Intensity Modulated Radiotherapy (IMRT) in the postoperative treatment of an adenocarcinoma of the endometrium complicated by a pelvic kidney

Purpose

To report early observation of transient PSA elevations on this pilot study of external beam radiation therapy and magnetic resonance imaging (MRI) guided high dose rate (HDR) brachytherapy boost.

Materials and methods

Eleven patients with intermediate-risk and high-risk localized prostate cancer received MRI guided HDR brachytherapy (10.5 Gy each fraction) before and after a course of external beam radiotherapy (46 Gy). Two patients continued on hormones during follow-up and were censored for this analysis. Four patients discontinued hormone therapy after RT. Five patients did not receive hormones. PSA bounce is defined as a rise in PSA values with a subsequent fall below the nadir value or to below 20% of the maximum PSA level. Six previously published definitions of biochemical failure to distinguish true failure from were tested: definition 1, rise >0.2 ng/mL; definition 2, rise >0.4 ng/mL; definition 3, rise >35% of previous value; definition 4, ASTRO defined guidelines, definition 5 nadir + 2 ng/ml, and definition 6, nadir + 3 ng/ml.

Results

Median follow-up was 24 months (range 18–36 mo). During follow-up, the incidence of transient PSA elevation was: 55% for definition 1, 44% for definition 2, 55% for definition 3, 33% for definition 4, 11% for definition 5, and 11% for definition 6.

Conclusion

We observed a substantial incidence of transient elevations in PSA following combined external beam radiation and HDR brachytherapy for prostate cancer. Such elevations seem to be self-limited and should not trigger initiation of salvage therapies. No definition of failure was completely predictive.     

The Frequency of New Permanent Pacemaker Implantations in 1975, 1980 and 1990 A Model Study Taking into Account the Dependence of Age and Sex

Statistics of the number of new, permanent pacemaker systems per year have been obtained for various countries since the end of the 1960's. These figures have been expressed mostly as the number of new paced patients per million inhabitants. There is a progressive increase in the need of a pacemaker with increasing age. Demographic data show considerable differences in the number of elderly in the various countries. More pacemakers have been implanted in males than in females, The predicted number of new permanent pacemaker systems in 1960 and 1990 has been calculated for eleven countries and has been estimated to be 200 per million inhabitants of the total population (age and sex distributions in the populations have been taken into account). Considerable differences appear.