Chronic candidiasis of the oral cavity and esophagus

Chronic candidiasis of the oral cavity and esophagus may present with a varying clinical picture. Three cases of this entity are presented. Infection occurs when the ecologic balance of normal flora and local factors are upset. Predisposing factors are listed. The different presentations, methods of evaluation, diagnosis, treatment alternatives, and immunologic applications are discussed. The problems of the chronic form of the disease, with it becoming deeply ingrained and recurrent, are stressed.     

对贵州地区249例汉族、苗族、布依族及侗族大学生进行 MMPI 测查的初步分析

作者用明尼苏达多相个性调查表对贵州地区249例汉族、苗族、布依族及侗族大学生进行了测查,结果表明:我省汉族男女大学生各量表 T 分均与全国标准值相似。而 Pt、Sc、Ma 量表原始分数与苗、布、侗族男女大学生组相比均有显著差异(P<0.05),表明了在汉族大学生与苗、布依、侗族大学生以及这三种少数民族之间有个性差异。     

Bypassing human CoQ10 deficiency

Primary disorders of the human coenzyme Q₁₀ (CoQ₁₀) biosynthesis pathway are a known cause of severe pediatric diseases. So far, oral administration of CoQ₁₀ is the only treatment strategy for affected individuals. However, the real benefit of CoQ₁₀ supplementation remains questionable and clinical studies regarding efficiency are lacking. Here we provide an outlook on novel treatment approaches using CoQ precursor compounds. These metabolic bypass strategies might be a promising alternative for oral CoQ₁₀ supplementation regimens.     

Tumor suppressor gene TP53 is genetically associated with schizophrenia in the Chinese population

Schizophrenia is a debilitating mental disorder. The TP53 tumor suppressor gene, encoding a phosphoprotein, is a key element in maintaining genomic stability and cell apoptosis. Recently, reduced risk of cancer in patients of schizophrenia has been reported. Some evidence also suggests the possible implication of TP53 in neurodevelopment. In order to examine the role of the TP53 gene in the pathogenesis of schizophrenic disorders, we investigated the genetic association between a functional polymorphism rs1042522 and schizophrenia by sequencing the fragment covering 72Pro> Arg in 701 cases and 695 controls in this work. In addition, we studied two other SNPs rs2078486 and rs8064946 by allele-specific PCR in the same samples. Though rs1042522 and rs8064946 did not show positive association with schizophrenia, we did observe statistically significant differences on SNP rs2078486 (P-value = 0.029; OR = 1.21; 95% CI 1.02-1.42) and on haplotype CAC (P-value = 0.0068; OR = 1.36; 95% CI 1.09-1.70). These results demonstrated that TP53 might play a role in susceptibility to schizophrenia.