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Preethi Jeyaraman Narendra Agrawal Rahul Bhargava Divya Bansal Rayaz Ahmed Dinesh Bhurani Sachin Bansal Neha Rastogi Pronamee Borah Rahul Naithani 《Transfusion and apheresis science》2021,60(3):103075
BackgroundData on convalescent plasma therapy (CPT) in patients of hematological malignancies with severe Covid-19 is scarce.ObjectiveTo study 14-day mortality in patients who received CPT.Patients & methodsRetrospective multicentre observational study conducted in 4 centres treating haematological malignancies across Delhi-national capital region. Total 33 haematological malignancies patients with severe Covid-19 who received CPT were analysed.ResultsThe median age of the study cohort was 62 years (18–80 years). Twenty one percent patients had 1 comorbidity, 18 % had 2 comorbidities and 6% patients had 3 and 5 comorbidities each. Twenty four patients were on active therapy. Sixty nine percent of patients required ICU stay. Twenty five patients received plasma therapy within 7 days (early) of diagnosis of Covid-19 infection. Median day of plasma infusion from date of diagnosis of Covid-19 infection was 4 days (range: 2–25 days). Patient who had early initiation of plasma therapy had shorter duration of hospitalisation (12.7 vs 24.3 days, p = 0.000). Overall mortality in the cohort was 45.5%. There was no effect of disease status, active therapy, presence of comorbidity on mortality. There was no difference in the mortality in patients receiving early vs late initiation of plasma therapy or in patients receiving one versus two plasma therapy.ConclusionsWe provide a large series of patients with hematological malignancies and role of CPT in this group. 相似文献
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Augmented‐reality‐based skills training for robot‐assisted urethrovesical anastomosis: a multi‐institutional randomised controlled trial 下载免费PDF全文
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Dinesh R Singh Geoiphy G Pulickal Zhiwen J Lo Wilfred CG Peh 《Singapore medical journal》2015,56(9):523-527
A 28-year-old Chinese man presented with acute bleeding per rectum. Computed tomography showed a posterior outpouching arising from the distal ileum. The outpouching had hyperaemic walls, but no active contrast extravasation was detected. Technetium-99m pertechnetate scintigraphy showed focal areas of abnormal uptake in the right side of the pelvis, superior and posterior to the urinary bladder. These areas of uptake appeared simultaneously with the gastric uptake and demonstrated gradual increase in intensity on subsequent images. The diagnosis of Meckel’s diverticulum was confirmed on surgery and the lesion was resected. The clinical and imaging features of Meckel’s diverticulum are discussed. 相似文献
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Dinesh C Doval Komal Bhatia Keechelat Pavithran Jai Bhagwan Sharma Ashok K Vaid Digant Hazarika 《Hepatobiliary & Pancreatic Diseases International》2006,(2)
Gallbladder metastases are very rare and usually arise from malignant melanoma, renal cell carcinoma and cervical carcinoma. Breast carcinoma tnetastatic to the gallbladder is extremely rare and only 4 cases have been reported in the English literature. We hereby report a 54-year-old lady who was diagnosed as having breast carcinoma and underwent modified radical mastectomy. One month after the operation, she developed acute abdomenal pain and underwent cholecystectomy after clinical investigation. Histopathological examination revealed metastasis to the gallbladder. Being considered a patient with tnetastatic breast carcinoma she was subjected to taxane and anthracycline-based palliative chemotherapy. Later she had CNS involvement and died of the progressive disease soon after few months. 相似文献
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Louise M. Buhre M.D. Dr. René-C. J. Verschueren M.D. Ph.D. Dinesh M. Mehta M.D. Jan Oldhoff M.D. Ph.D. 《Diseases of the colon and rectum》1987,30(5):352-354
The authors report their experience with the staging laparotomy as a means of identifying and preparing patients for high-dose
preoperative radiotherapy. Twelve patients had clinically unresectable cancers of the rectum. The goal of the staging laparotomy
is to assess mobility and tumor size by means of bimanual palpation, to stage the abdominal cavity, and to fashion an end
colostomy at the level of the descending colon. Eight patients ultimately underwent radical resection. Three died during follow-up
due to hematogenic metastases without recurrent pelvic disease. Five patients are alive with no evidence of disease and have
been followed for an average of 34 months (range, 20 to 64 months). 相似文献
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Hywyn Churchill Harris Naina Richard Boriack Dinesh Rakheja Weina Chen 《International journal of clinical and experimental pathology》2015,8(9):11753-11759
Objectives: Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive peripheral T-cell lymphoma with mutations in genes encoding isocitrate dehydrogenase1 and 2 (IDH1 and IDH2). Mutant IDH generates the oncometabolite D-2-hydroxyglutarate (D-2HG). We report the first case of discordant intracellular and plasma D-2HG levels in a patient with IDH2 R172S mutated AITL. Methods: An 87-year-old woman was diagnosed with AITL in the groin lymph node by morphologic and immunophenotypic analyses, and molecular studies by DNA sequencing. D-2HG was measured in both tumoral tissue and in pre-treatment plasma by liquid chromatography-tandem mass spectrometry. Results: While D-2HG was markedly elevated in the tissue sample, its level in plasma was normal. We discuss this discordant D-2HG result within the context of previously reported discordant 2HG results in other IDH mutated tumors, and its implication for using circulating D-2HG as a biomarker of IDH mutation. In addition, this case also harbored mutations in RHOA, TET2, and TP53. The molecular pathogenesis is briefly discussed. Conclusion: While our case suggests that circulating D-2HG is not a reliable marker of IDH mutation in AITL, more cases need to be studied to arrive at a definite conclusion. 相似文献