全文获取类型
收费全文 | 116285篇 |
免费 | 5959篇 |
国内免费 | 141篇 |
专业分类
耳鼻咽喉 | 1776篇 |
儿科学 | 5217篇 |
妇产科学 | 3937篇 |
基础医学 | 16078篇 |
口腔科学 | 2848篇 |
临床医学 | 8352篇 |
内科学 | 22068篇 |
皮肤病学 | 3359篇 |
神经病学 | 9001篇 |
特种医学 | 5051篇 |
外国民族医学 | 32篇 |
外科学 | 19075篇 |
综合类 | 1596篇 |
一般理论 | 29篇 |
预防医学 | 5808篇 |
眼科学 | 3393篇 |
药学 | 8046篇 |
2篇 | |
中国医学 | 324篇 |
肿瘤学 | 6393篇 |
出版年
2018年 | 892篇 |
2017年 | 777篇 |
2016年 | 1097篇 |
2015年 | 1224篇 |
2014年 | 1606篇 |
2013年 | 2376篇 |
2012年 | 3105篇 |
2011年 | 3153篇 |
2010年 | 1980篇 |
2009年 | 1941篇 |
2008年 | 3274篇 |
2007年 | 3498篇 |
2006年 | 3651篇 |
2005年 | 3752篇 |
2004年 | 3699篇 |
2003年 | 3571篇 |
2002年 | 3521篇 |
2001年 | 7020篇 |
2000年 | 6959篇 |
1999年 | 5861篇 |
1998年 | 1623篇 |
1997年 | 1558篇 |
1996年 | 1337篇 |
1995年 | 1203篇 |
1994年 | 1092篇 |
1993年 | 1120篇 |
1992年 | 3768篇 |
1991年 | 3576篇 |
1990年 | 3561篇 |
1989年 | 3349篇 |
1988年 | 2985篇 |
1987年 | 2895篇 |
1986年 | 2803篇 |
1985年 | 2618篇 |
1984年 | 1943篇 |
1983年 | 1595篇 |
1982年 | 929篇 |
1981年 | 915篇 |
1980年 | 765篇 |
1979年 | 1822篇 |
1978年 | 1346篇 |
1977年 | 1111篇 |
1976年 | 936篇 |
1975年 | 1178篇 |
1974年 | 1212篇 |
1973年 | 1198篇 |
1972年 | 1040篇 |
1971年 | 975篇 |
1970年 | 880篇 |
1969年 | 787篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
This study investigated the differences in color perception among distinct groups of dental personnel. Four groups of dental personnel (10 dental technicians, 15 final-year dental students, 15 general practitioners and 10 prosthodontists) were asked to match seven test tabs of shades A1, A4, B2, B3, C2, C4 and D3 (Z100 shade guide, 3M Dental Products, St Paul, MN 55144, USA) against a standard Vita shade guide under similar lighting conditions. The results obtained were computed into L*a*b* values using a small-area colorimeter (Dental Colorimeter, Minolta Camera Pte Ltd). The data were analyzed using one-way ANOVA/post-hoc Scheffe's test at significant level p<0.05. The results showed significant differences in deltaE (color difference) between the dental technicians and the clinicians for shade C4. The significant difference that was observed in deltaE for dark shades between dental personnel was mainly contributed to a disparity in L* values. A significant difference in deltaL* was observed between dental technicians and prosthodontists for shade C4. 相似文献
102.
U Br?gger E Schürch G Salvi T von Wyttenbach N P Lang 《The Cleft palate-craniofacial journal》1992,29(2):179-185
The present study assessed the progression rate of periodontal disease over 8 years in a group of 52 adult patients with various forms of cleft lip, alveolus, and palate considered at risk for progression of periodontal disease. Of special interest was the evaluation of periodontal disease progression at sites adjacent to cleft regions compared to changes found at control sites not directly affected by such defects. High incidences of generalized plaque accumulation and bleeding on probing were noted at both examinations in 1979 and 1987. A mean apical shift of the clinical attachment level amounting to 0.2 mm had occurred over the 8-year observation period. A slight apical displacement of the mesial and distal mean crestal alveolar bone was also noted. The rate of progression of periodontal disease over the 8 years was not found to be different at statistically significant levels at cleft sites compared to control sites. However, the results of this study documented that the cumulative periodontal destruction at 26 to 28 years of age was statistically significant and more pronounced at cleft sites as revealed by greater probing pocket depth and loss of clinical attachment. The differences between test and control sites amounted to 0.3 and 0.4 mm respectively for probing depth and 0.6 mm for loss of clinical attachment. In addition, the discrepancy between alveolar bone height and the levels of the clinical attachment at cleft sites demonstrated the presence of a long supracrestal connective tissue attachment adjacent to cleft defects. Therefore, the alveolar bone height as visualized in radiographs at such sites was considered an unreliable diagnostic tool for the assessment of the degree of periodontal destruction. 相似文献
103.
Light and electron microscopy were used to analyze nine therapy-resistant and asymptomatic human periapical lesions, which were removed as block biopsies during surgical treatment of the affected teeth. The cases that required surgery represented about 10% of all of the cases which received endodontic treatment and root fillings during the period 1977 to 1984. These cases revealed periapical lesions when they were examined 4 to 10 yr after treatment. The biopsies were processed for correlated light and electron microscopy. Six of the nine biopsies revealed the presence of microorganisms in the apical root canal. Four contained one or more species of bacteria and two revealed yeasts. Of the four cases in which bacteria were found, only in one biopsy could they be found by light microscope. In the other three specimens, the bacterial presence could be confirmed only after repeated electron microscopic examination of the apical root canal by serial step-cutting technique. Among the three cases in which no microorganisms could be encountered, one showed histopathological features of a foreign body giant cell granuloma. These findings suggest that in the majority of root-filled human teeth with therapy-resistant periapical lesions, microorganisms may persist and may play a significant role in endodontic treatment failures. In certain instances such lesions may also be sustained by foreign body giant cell type of tissue responses at the periapex of root-filled teeth. 相似文献
104.
The treatment of partially edentulous patients with ITI hollow-screw implants: presurgical evaluation and surgical procedures 总被引:1,自引:0,他引:1
D Buser H P Weber U Br?gger 《The International journal of oral & maxillofacial implants》1990,5(2):165-175
The ITI hollow-screw implant is part of the new ITI Bonefit concept, which is based on more than 10 years of clinical experience with former ITI implants. Among other properties, ITI implants are characterized by a one-stage surgical procedure. This article describes the presurgical evaluation and surgical procedures for the treatment of partially edentulous patients with ITI hollow-screw implants. Of 111 implants placed, 110 revealed a complication-free tissue integration and one failed. These results demonstrate that one-stage ITI hollow-screw implants have a high predictability for successful tissue integration. 相似文献
105.
In the light of personal studies and relevant reports in the literature, the authors deal with gagging during dental treatment and after denture insertion. In this connection, aetiopathologic and therapeutic aspects of the gagging syndrome are analysed. It is postulated that the gagging reaction is a conditioned anxiety reaction. 相似文献
106.
Mast cells of the human gingiva 总被引:1,自引:0,他引:1
Comparative histochemical studies with specific regard to the demonstration of mast cells were carried out on 21 different chronically inflamed marginal gingival specimens. For the demonstration of sulphated acid mucopolysaccharides two metachromatic stains were used-toluidine blue (pH 1.0) and acridine orange (pH0.5)-, as well as one orthochromatic stain- astra blue (pH 0.2–0.3). In addition the alcian blue-safranin sequence was employed to distinguish between weakly and strongly sulphated mucopolysaccharides. Trypsin-like esterase activity was demonstrated by the EACNAS-GBC technique. The metachromatic stains used stain mature mast cells specifically, while the non-metachromatic techniques stain immature mast cells as well. The chemical backgrounds for the different staining reactions are discussed. The chronically inflamed human gingivae were found to be rich in both mature and immature mast cells. The great majority of the immature mast cells were found within the pocket area of the connective tissue. Here, the number of mature mast cells was significantly smaller than in the oral area. The distribution of the different mast cell variants indicate a relation between mast cells and diffusible products from the gingival bacterial plaque. 相似文献
107.
Within a monometallic concept 29 patients received titanium bar‐retained mandibular overdentures on 2 IMZ implants. The study had a prospective design with 3 months recall intervals. One of 58 implants failed after 11 months. There were no significant differences of the mean plaque scores (Silness, Löe) and the mean sulcus bleeding scores (Mühlemann, Son) at the abutments between baseline, 12 months and 24 months. Less than 40% of the subjects showed plaque score zero at 24 months. However, 89% exhibited sulcus bleeding score zero indicating health of the peri‐implant soft tissues in most cases. Plaque at the basal site of the bar was scored separately at additional measuring points located at the central area and the contact areas between bar and abutments. Bar plaque scores nearly doubled between baseline and 12 months and remained high at 24 months. Median maximal vertical bone loss around the implants was 1.7 mm after 2 years. Bone loss did not exceed one quarter of the implant length in 79%. The monometallic concept in bar‐retained overdentures on 2 implants proved its clinical suitability except for the applicability of pure titanium for bar clips. Plaque formation beneath the bar seems to be one of the major clinical problems. 相似文献
108.
Becker W Dahlin C Lekholm U Bergstrom C van Steenberghe D Higuchi K Becker BE 《Clinical implant dentistry and related research》1999,1(1):27-32
Background: Barrier membranes have been used to promote bone ingrowth on implants with dehiscences and fenestrations. Membranes also have been used to protect defects adjacent to implants placed at the time of extraction. The concept of guided bone regeneration relates to preferentially allowing cells from bone to migrate into various defects while excluding fibrous tissue and epithelium. The purpose of these procedures is to enhance bone-to-implant contact at the treated sites and to prevent mucosal complications. Purpose: The purpose of this article is to report clinical outcomes for implants placed at the time of extraction and augmented with expanded polytetrafluoroethylene (ePTFE) and followed for 5 years. The outcomes for implants with dehiscences and fenestrations augmented with ePTFE barriers and followed up to 5 years also are reported. Methods and Materials: Four treatment centers participated in this study (Tucson, Gothenburg, Spokane, and Leuven). In the extraction group, teeth were removed for varying reasons, and Brånemark implants were placed and stabilized within the host bone. Defects present at the coronal implant aspect were covered with ePTFE barrier membranes. Flaps were rotated to cover the membrane-treated sites. If exposure of the material occurred prior to second-stage surgery, the membranes were removed. Barriers remaining unexposed were removed at second-stage surgery. The implants were followed up to 5 years. In the fenestration and dehiscence group, implants with exposed threads were augmented with ePTFE barrier membranes. The barriers were removed at appropriate intervals, and the patients were followed up to 5 years. Radiographic measurements were made from nonstandardized periapical radiographs at abutment connection and 1, 3, and 5-year follow-up visits. Results: Forty patients participated in the extraction group. They received a total of 49 implants. Three implants failed prior to loading. The 5-year cumulative survival rates for implants placed at the time of extraction were 93.9% and 93.8%, respectively, for maxillary and mandibular implants. The average maxillary mesial and distal marginal bone loss (1–5 yr) was 0.3 mm (standard deviation [SD] = 1.5) and 0.3 mm (SD = 1.0). In mandibles, the average mesial and distal bone loss (1–5 yr) was -0.2 mm (SD = 0.5) and -0.05 mm (SD = 0.6), respectively. The dehiscence and fenestration group included 44 patients. Twenty-six were followed for up to 5 years. Eight patients experienced total implant failure. For dehiscences and fenestrations, the cumulative survival rates were 76.8% and 83.8% for maxillary and mandibular implants, respectively. The average maxillary mesial and distal bone loss (1–5 yr) was 0.4 mm (SD = 0.8) and 0.2 mm (SD = 0.9), respectively. In mandibles, the average mesial and distal marginal bone loss was 0.3 mm (SD = 0.9) and 0.3 mm (SD = 0.8), respectively. Conclusions: Implants placed at the time of extraction and augmented with ePTFE barrier membranes have favorable long-term predictability. On the other hand, long-term evaluation of implant dehiscences and fenestrations augmented with barrier membranes indicates that they have less favorable 5-year survival rates. Membrane augmentation of these may be questioned. 相似文献
109.
Abstract A total of 356 patients with mandibular condyle fractures were studied regarding associated dental injuries. One third of the patients had injured teeth, on average, 3.7 teeth had been injured per accident. Dental traumas were distributed equally between the anterior (incisors and canines) and posterior teeth (premolars and molars) in both jaws. In unilateral condylar fracture cases maxillary dental injuries involved more often premolars and/or molars of the fracture side than those of the non-fracture side. The mean number of dental traumas in the mandible was higher in cases of simultaneous mandibular body fracture than without, whereas the presence of mandibular body fracture did not affect number of associated dental injuries in the maxilla. The dental injuries were mostly to hard tissue (78%), which were commonest in men, 20 to 29 years of age, and in victims of violence or fall accidents. Severe dental injuries in association with mandibular condyle fractures were more common in accidents due to traffic and miscellaneous causes than in those due to violence. Severe dental injuries were more often encountered when simultaneous mandibular body fracture was present than when it was not and more so in bilateral than unilateral condylar fracture cases. The most important factor correlating with the severity of dental injuries was the presence of bilateral condylar fracture. 相似文献
110.
Maier A Gaggl A Klemen H Santler G Anegg U Fell B Kärcher H Smolle-Jüttner FM Friehs GB 《The British journal of oral & maxillofacial surgery》2000,38(3):173-176
We reviewed 41 patients with osteoradionecrosis of the mandible. Each patient was treated by radical resection followed by external beam irradiation. The diagnosis of infected osteoradionecrosis was confirmed clinically, radiologically, and histologically. After operation had failed, 20/41 were given hyperbaric oxygen (HBO) as in 'salvage' treatment. Daily sessions of HBO 2.5 ATA for 60 minutes (mean: 29 sessions) were given. The other 21 patients were treated by operation and antibiotics alone. HBO group (n = 20): The overall success rate for HBO after operation had failed was 13/20. Repeated debridement as first-line treatment followed by postoperative HBO was successful in 12/19. In seven of 19 patients, partial mandibulectomy and microvascular transplantation were required as second-line treatment, and this was successful in five. Primary partial mandibulectomy and microvascular transplantation followed by HBO was successful in 1 patient. Non-HBO group (n = 21): Repeated debridement was successful in 10/11 patients. Partial mandibulectomy was required as second-line treatment in the remaining one. In the other 10, partial mandibulectomy and microvascular transplantation were successful as first-line treatment in four. In the remaining six, further surgical intervention became necessary and were successful for 5-17 months (mean: 13). With a success rate of 13/20, we do not recommend HBO for the treatment of osteoradionecrosis. 相似文献