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941.
Alexandre Simões Nogueira Eduardo Sanches Gonçales Paulo Sergio da Silva Santos José Humberto Damante Phillipe Nogueira Barbosa Alencar Fernanda Araújo Sampaio Alexandre Simões Garcia 《Surgical and radiologic anatomy : SRA》2013,35(9):867-871
Despite the nomenclature suggested to be a tumor, torus palatinus (TP) is an overgrowth of the bone in the palatal region and represents an anatomic variation. Its prevalence varies among the population studied and its etiology is still unclear; however, it seems to be a multifactorial disorder with genetics and environmental involvement. Surgical removal of the TP is indicated in the following circumstances: (1) deglutition and speech impairment, (2) cancer phobia, (3) traumatized mucosa over the torus, and (4) prosthetic reasons. The aim of this case report is describe cases that occurred in two sisters, emphasizing the genetic etiology of this anatomic variation. In addition, intra-oral exam and computed tomography scan (axial, coronal and sagittal view) provided a detailed assessment of the TP and elimination of other possible diagnoses, furthermore allowed a better analyzes of the anatomic relation with adjacentes structures. No surgical removal was indicated for both cases. 相似文献
942.
Chiang Jannifer O. Azevedo Rafael S. Justino Maria C. A. Matos Haroldo J. Cabeça Hideraldo L. S. Silva Sandro P. Henriques Daniele F. Silva Eliana V. P. Andrade Gabriela S. S. Vasconcelos Pedro FC. Martins Lívia C. Azevedo Raimunda S. S. 《Journal of neurovirology》2021,27(4):626-630
Journal of NeuroVirology - We describe two neurological cases of Oropouche virus infection in northern Brazil, where the virus is endemic but neglected as a pathogen. This study reiterates the... 相似文献
943.
Rodney A. Bray Elisabeth Faliex Jean François Allienne Gabriel Mouahid 《Parasitology research》2013,112(12):3981-3989
Lepidapedon sereti n. sp. is described from the macrourid Coelorinchus sereti from the deep water off Vanuatu. It is placed in the Elongatum group and Elongatum subgroup. It differs from the other species described in this subgroup by the distinctly dorsally subterminal excretory pore. It also differs from other species in combinations of size, excretory vesicle length, proportions of forebody, post-testicular region and other metric features. This constitutes the first record of a Lepidapedon (sensu stricto) from the Central Western Pacific Ocean. 相似文献
944.
J. Brauner M. Hallin A. Deplano R. De Mendonça C. Nonhoff R. De Ryck S. Roisin M. J. Struelens O. Denis 《European journal of clinical microbiology & infectious diseases》2013,32(5):613-620
The present study reports the evolution of the demographic characteristics and the molecular epidemiology of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) in Belgium from 2005 to 2009. Four hundred and ten CA-MRSA isolates were prospectively collected and screened for the presence of Panton–Valentin leucocidin (PVL) and toxic shock syndrome toxin 1 (TSST-1) encoding genes, while clinical information were recorded. PVL- and TSST-1-positive isolates were genotyped by pulsed-field gel electrophoresis (PFGE). Staphylococcal cassette chromosome mec (SCCmec) type, spa type and multilocus sequence type (MLST) were determined on representative isolates. One hundred and fifty-nine (39 %) isolates were PVL-positive. PVL-positive isolates were significantly more frequently isolated from skin or soft tissue than PVL-negative isolates, causing mainly subcutaneous abscesses and furuncles. Patients with PVL-positive CA-MRSA were significantly younger than patients with PVL-negative CA-MRSA. Eighty-seven percent of the PVL-positive isolates belonged to a limited number (n?=?7) of PFGE types belonging to sequence types (ST) ST80, ST8, ST30, ST5, ST152, ST338 and a new ST, a single-locus variant of ST1. A temporal evolution of the distribution of these PFGE types was observed, characterised by (1) the dissemination of the ST8-SCCmecIV arcA-positive (USA300) genotype and (2) a genetic diversification. Forty-seven (11 %) strains were TSST-1-positive, of which 65 % clustered into four PFGE types, all belonging to ST5. The epidemiology of CA-MRSA in Belgium is changing, as the rapid diffusion of the USA300 clone seems to occur, together with a clonal diversification. 相似文献
945.
Mariana Leandro Leandro Andrade Luciano Vespoli Julia Moreira Vivian Pimentel Fabiano Soares Lucas Passamani Vanildo Silveira Gonçalo de Souza Filho 《Research in microbiology》2021,172(1):103785
Plant growth-promoting bacteria are a promising alternative to improve agricultural sustainability. Gluconacetobacter diazotrophicus is an osmotolerant bacterium able to colonize several plant species, including sugarcane, coffee, and rice. Despite its biotechnological potential, the mechanisms controlling such osmotolerance remain unclear. The present study investigated the key mechanisms of resistance to osmotic stress in G. diazotrophicus. The molecular pathways regulated by the stress were investigated by comparative proteomics, and proteins essential for resistance were identified by knock-out mutagenesis. Proteomics analysis led to identify regulatory pathways for osmotic adjustment, de novo saturated fatty acids biosynthesis, and uptake of nutrients. The mutagenesis analysis showed that the lack of AccC protein, an essential component of de novo fatty acid biosynthesis, severely affected G. diazotrophicus resistance to osmotic stress. Additionally, knock-out mutants for nutrients uptake (Δtbdr and ΔoprB) and compatible solutes synthesis (ΔmtlK and ΔotsA) became more sensitive to osmotic stress. Together, our results identified specific genes and mechanisms regulated by osmotic stress in an osmotolerant bacterium, shedding light on the essential role of cell envelope and extracytoplasmic proteins for osmotolerance. 相似文献
946.
Rogier Thomas Eberl Isabelle Moretto Florian Sixt Thibault Catherine François-Xavier Estève Clémentine Abdallahoui Maroua Behague Lucile Coussement Antoine Mathey Lucas Mahy Sophie Buisson Marielle Salmon-Rousseau Arnaud Duong Michel Chavanet Pascal Bernard Quentin Nicolas Barbara Benguella Leila Bonnotte Bernard Blot Mathieu Piroth Lionel 《European journal of clinical microbiology & infectious diseases》2021,40(9):2023-2028
European Journal of Clinical Microbiology & Infectious Diseases - During an epidemic period, we compared patients hospitalized for initial suspicion of COVID-19 but for whom an alternative... 相似文献
947.
Marine Mommert Magali Perret Matthew Hockin Sébastien Viel Alexandre Belot Jean-Christophe Richard Mehdi Mezidi Jean-Baptiste Fassier Etienne Javouhey ANTOINE Study Group COVID-SER Study Group COVID-HCL Study Group Andrew Hemmert François Mallet Sophie Trouillet-Assant Karen Brengel-Pesce 《European journal of immunology》2021,51(4):989-994
Low concentrations of type-I interferon (IFN) in blood seem to be associated with more severe forms of Coronavirus disease 2019 (COVID-19). However, following the type-I interferon response (IR) in early stage disease is a major challenge. We evaluated detection of a molecular interferon signature on a FilmArray® system, which includes PCR assays for four interferon stimulated genes. We analyzed three types of patient populations: (i) children admitted to a pediatric emergency unit for fever and suspected infection, (ii) ICU-admitted patients with severe COVID-19, and (iii) healthcare workers with mild COVID-19. The results were compared to the reference tools, that is, molecular signature assessed with Nanostring® and IFN-α2 quantification by SIMOA® (Single MOlecule Array). A strong correlation was observed between the IR measured by the FilmArray®, Nanostring®, and SIMOA® platforms (r-Spearman 0.996 and 0.838, respectively). The FilmArray® panel could be used in the COVID-19 pandemic to evaluate the IR in 45-min with 2 min hand-on-time at hospitalization and to monitor the IR in future clinical trials. 相似文献
948.
de França Juliane Santos de Sales-Neto José Marreiro Carvalho Deyse Cristina Madruga de Almeida Lima Éssia Olegário Tayná Rodrigues Mendes Rhuan Karlos Santos Lima-Junior Claudio Gabriel de Almeida Vasconcellos Mário Luiz Araújo Rodrigues-Mascarenhas Sandra 《Inflammation》2021,44(3):899-907
Inflammation - Morita-Baylis-Hillman adducts (MBHA) are synthetic molecules with several biological actions already described in the literature. It has been previously described that adduct... 相似文献
949.
Lu Bai Mohammad Webhi Guillaume Dolphijn Bruno Amduri Jean‐Franois Gohy 《Macromolecular chemistry and physics.》2021,222(1)
Solid polymer electrolytes are prepared by mixing various amounts of lithium bis(trifluoromethanesulfonyl)imide with poly(vinylidene fluoride‐co‐vinyl dimethyl phosphonate) statistical copolymers with different compositions. Such copolymers are obtained by conventional radical copolymerization of vinylidene fluoride (VDF) with vinyl dimethyl phosphonate (VDMP) initiated by peroxides. A morphological study of the obtained solid polymer electrolytes (SPEs) shows that only samples prepared from the copolymer with the lower amount of VDMP (16 mol%) result in the formation of homogeneous electrolytes while aggregates of lithium salts are observed for the other copolymers. The best ionic conductivity values are accordingly observed for the copolymers with the lower VDMP amount and are reaching 5 × 10?3 mS cm?1 at 100 °C. The dependence of the ionic conductivity versus temperature suggests that the ionic conductivity is controlled by the motion of polymer segments. Indeed, the ionic conductivity can be increased by adding a small amount of trimethylphosphate plasticizer and can reach 1.9 × 10?2 mS cm?1 at 20 °C. Finally, the prepared SPEs exhibit a high electrochemical stability and a good resistance to flame because of the presence of fire‐retardant phosphate groups in their structure. 相似文献
950.
Dafne D.G. Horovitz Emília K.E.A. Leão Erlane M. Ribeiro Ana M. Martins Anneliese L. Barth João I.C.F. Neri Marcelo Kerstenetzky Ana C.M. Siqueira Bethania F.R. Ribeiro Chong A. Kim Francisca C. Santos José F.S. Franco Leniza C.L. Lichtvan Liane R. Giuliani Maria Do C.S. Rodrigues Renata C.F. Bonatti Thaís B. Teixeira Alexandra Gonçalves Angelina X. Acosta 《Molecular genetics and metabolism》2021,132(1):94-99
Patients with mucopolysaccharidosis type VI (MPS VI) present with a wide range of disease severity and clinical manifestations, with significant functional impairment and shortened lifespan. Enzyme replacement therapy (ERT) with galsulfase has been shown to improve clinical and biochemical parameters including patient survival, quality of life and growth. The present study is a resurvey of 34 Brazilian MPS VI patients with rapidly progressive disease (classical phenotype) who initiated ERT with galsulfase under five years of age and had been on ERT until data collection in 2019, with few exceptions (n = 4 patients who died before 2019).Anthropometric measures, urinary glycosaminoglycans, and data regarding cardiac, orthopedic, neurologic, sleep apnea, hearing and ophthalmologic outcomes were filled in by specialists. Pubertal development, clinical complications, hospitalizations, and surgeries were also assessed.In this resurvey study, treatment with galsulfase has shown to be safe and well tolerated in MPS VI patients who initiated ERT under the age of 5 years and who have been undergoing ERT for approximately 10 years. Mortality rate suggests that early initiation of ERT may have a positive impact on patients' survival, improving but not preventing disease progression and death. MPS VI patients on ERT also showed improved growth velocity and the pubertal development was normal in all surviving patients.Follow-up data on pneumonia and hospitalization suggest that early ERT may have a protective effect against major respiratory complications. Cardiac valve disease progressed since their prior evaluation and spinal cord compression was observed in a large number of patients, suggesting that these disease complications were not modified by ERT. 相似文献