全文获取类型
收费全文 | 30309篇 |
免费 | 919篇 |
国内免费 | 198篇 |
专业分类
耳鼻咽喉 | 173篇 |
儿科学 | 716篇 |
妇产科学 | 446篇 |
基础医学 | 4507篇 |
口腔科学 | 434篇 |
临床医学 | 2406篇 |
内科学 | 5384篇 |
皮肤病学 | 355篇 |
神经病学 | 2516篇 |
特种医学 | 1251篇 |
外科学 | 4315篇 |
综合类 | 1922篇 |
一般理论 | 34篇 |
预防医学 | 2163篇 |
眼科学 | 488篇 |
药学 | 2260篇 |
28篇 | |
中国医学 | 63篇 |
肿瘤学 | 1965篇 |
出版年
2023年 | 146篇 |
2022年 | 491篇 |
2021年 | 1080篇 |
2020年 | 623篇 |
2019年 | 986篇 |
2018年 | 1634篇 |
2017年 | 1020篇 |
2016年 | 1399篇 |
2015年 | 1530篇 |
2014年 | 1737篇 |
2013年 | 2373篇 |
2012年 | 2124篇 |
2011年 | 1496篇 |
2010年 | 1716篇 |
2009年 | 1362篇 |
2008年 | 1304篇 |
2007年 | 1340篇 |
2006年 | 1155篇 |
2005年 | 1185篇 |
2004年 | 978篇 |
2003年 | 693篇 |
2002年 | 633篇 |
2001年 | 196篇 |
2000年 | 290篇 |
1999年 | 296篇 |
1998年 | 307篇 |
1997年 | 256篇 |
1996年 | 184篇 |
1995年 | 155篇 |
1994年 | 138篇 |
1993年 | 159篇 |
1992年 | 141篇 |
1991年 | 155篇 |
1990年 | 136篇 |
1989年 | 140篇 |
1988年 | 131篇 |
1987年 | 109篇 |
1986年 | 86篇 |
1985年 | 79篇 |
1984年 | 95篇 |
1983年 | 66篇 |
1982年 | 88篇 |
1981年 | 56篇 |
1980年 | 68篇 |
1978年 | 32篇 |
1977年 | 43篇 |
1975年 | 31篇 |
1971年 | 35篇 |
1970年 | 34篇 |
1968年 | 40篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
91.
B. J. Young R. O’Regan F. Kinsella A. Benedict-Smith M. McDermott M. Hillery L. M. T. Collum M. Hickey-Dwyer P. Mullaney J. Blake M. Hope-Ross S. Travers D. Mooney P. S. Phelan P. E. Cleary D. F. P. Larkin D. Roden P. Eustace H. N. O’Donoghue J. D. McAdoo J. G. Madden J. P. Burke M. O’Keefe R. Bowell M. O’Sullivan P. T. McLister D. J. Wilson J. Walsh 《Irish journal of medical science》1988,157(3):91-94
92.
93.
M. O’Mahony R. Conroy E. Shelley N. Hickey A. Radic 《Irish journal of medical science》1991,160(9):17-21
A myocardial infarction and stroke register was established in January 1987 as part of the evaluation of the Kilkenny Health
Project This is a community programme which aims to reduce risk factors for coronary heart disease. The register records acute
myocardial infarction and stroke in residents of County Kilkenny and of the reference county. This will provide accurate estimates
of the incidence of these diseases and of trends over time.
Methods used comply with the protocol in use by the WHO MONICA Project. This will allow comparison of the incidence of coronary
heart disease and stroke in this register with that in other MONICA locations, including that in Belfast, Northern Ireland. 相似文献
94.
95.
Antonella d’Arminio Monforte Paola Cinque Luca Vago Aleandro Rocca Antonella Castagna Cristina Gervasoni Maria Rosa Terreni Roberto Novati Andrea Gori Adriano Lazzarin Mauro Moroni 《Journal of neurology》1996,244(1):35-39
Twenty patients with AIDS who had intracranial lesions underwent both brain biopsy and cerebro-spinal fluid (CSF) examination
to compare histological diagnosis with the polymerase chain reaction (CSF-PCR) for the identification of infectious agents.
CSF-PCR was performed for herpes simplex virus, varicella zoster virus, cytomegalovirus (CMV), JC virus (JCV), Epstein-Barr
virus (EBV), Toxoplasma gondii and Mycobacterium tuberculosis. A definitive diagnosis was obtained by brain biopsy in 14 patients (2 with astrocytoma, 12 with brain infection). CSF-PCR
was positive for EBV DNA in 3 of 3 cases of primary cerebral lymphoma, positive for JCV DNA in 6 of 7 biopsy-proven (and one
autopsy-proven) cases of progressive multifocal leukoencephalopathy (PML). CSF-PCR was positive for CMV DNA in one biopsy-proven
and one autopsy-proven case of CMV encephalitis (the former also had PML) and positive for M. tuberculosis DNA in one case of tuberculous encephalitis. None of the five toxoplasmic encephalitis cases (one definite, four presumptive)
were T. gondii DNA positive. There was close correlation between histology and CSF-PCR for CMV encephalitis, PML and PCL. Antitoxoplasma
therapy affected the sensitivity of both histological and CSF-PCR methods.
Received: 8 November 1995 Received in revised form: 9 July 1996 Accepted: 19 July 1996 相似文献
96.
97.
98.
Denis R. Clohisy Christian M. Ogilvie Margaret L. R. Ramnaraine 《Journal of orthopaedic research》1995,13(6):892-897
Details of the cellular and biochemical mechanisms involved in focal destruction of bone at sites of tumor osteolysis are unknown. It has been shown that tumors from sarcoma (2472) cell lines induce focal osteolysis in mice by stimulating formation and activation of osteoclasts. In this report, the influence of 2472 tumors on the skeletons of osteoclast-deficient animals (op/op) was studied. After op/op femora had been inoculated with 2472 cells, tumors developed and focal osteolysis occurred. There were more osteoclasts per histologic section in sham-injected femora (19 ± 5) than in tumor-bearing femora (412 ± 129) (p < 0.05). The size of the osteoclasts also increased from 304 ± 81 μm2 in sham-injected limbs to 407 ± 62 μm2 in tumor-bearing limbs (p < 0.001). Conditioned media from 2472 op/op tumor explants contained macrophage colony-stimulating factor. A deficiency of osteoclasts in op/op mice is the result of the absence of this factor; therefore, these data introduce the possibility that macrophage colony-stimulating factor derived from 2472 tumor may be responsible for directing osteoclast-mediated osteolysis at sites of the tumor. 相似文献
99.
Summary Surgical repair of enterocutaneous fistulae in Crohn’s disease may result in large skin defects of the anterior abdominal
wall. We present a case in which a large defect was managed with reconstruction using a pedicled rectus abdominis mycocutaneous
flap in a single procedure. The case highlights the technical challenge of such a case and the value of a joint surgical approach
between plastic and colorectal services. 相似文献
100.
Cinzia Azzoni Tiziana D’Adda Guido Tamburrano Carlo Coscelli Ole D. Madsen Lucio Scopsi C. Bordi 《Virchows Archiv : an international journal of pathology》1998,433(6):495-504
Sixty-seven insulinomas were investigated by immunohistochemistry using site-directed antibodies against insulin, proinsulin, chromogranin A, HISL-19, and four proteins directly or indirectly involved in the proteolytic processing of proinsulin: the prohormone convertases PC2 and PC3, carboxypeptidase H (CPH) and 7B2. Results were expressed in a six-grade score according to the frequency of immunoreactive tumour cells. Insulin was expressed by all tumours, appearing in either a diffuse or a polarized pattern and being detected in more than 30% of tumour cells in all cases but three. Proinsulin was also expressed in all tumours, with more than 50% of tumour cells immunoreactive in all cases but 5. It was consistently localized in the Golgi apparatus. In about half the cases, moreover, it also showed diffuse cytoplasmic staining, usually with a very sparse distribution. Trabecular and solid insulinomas did not present specific, homogeneous patterns of insulin immunostaining. However, insulin immunoreactivity was much more abundant in trabecular than in solid neoplasms, being present in virtually all tumour cells (score 6) in 50% and 8% of cases, respectively. Virtually all insulinomas expressed PC2, PC3, CPH and 7B2, usually in 30–100% of tumour cells, with a frequency significantly related to that of insulin. However, detection of PC2 and 7B2 was slightly less frequent than that of PC3 and CPH. In consecutive sections these proteins were found to be mostly co-localized with insulin and chromogranin A but not with proinsulin. They were heavily expressed in all 10 tumours with more than 10% of cells showing cytoplasmic proinsulin immunoreactivity, indicating that the leakage of proinsulin from the Golgi compartment is not associated with faulty expression of converting enzymes and possibly reflects a saturated processing capacity. HISL-19 immunoreactivity was found in both Golgi apparatus and insulin stores, indicating that the relevant antigen is different from all other proteins investigated. These results do not support a defect in expression or localization of proinsulin-processing enzymes in most insulinomas. 相似文献