Epidemiological and immunological research on cytomegaly in parturients and newborn infants among the indigenous and immigrant population in the Far North

In the immigrant population of the Central Yakutiya, cytomegalic cells in the saliva and urine are found much more frequently than in the indigenous population (P less than 0.001). Significant differences were found in the content of complement-fixing antibody to CMV in parturients and newborns in the Extreme North as compared with the European USSR. While in the latter complement-fixing antibodies to CMV are more frequently found in newborn babies (86% in newborns and 69.8% in parturients), in the Extreme North it is vice versa (52.53% in parturients and 32.73% in newborns). Large numbers of seronegative women of the indigenous and immigrant population becoming pregnant get into the group of risk of infection with CMV which is explained by a high rate of detection of IgM in newborn babies of the indigenous (8.69%) and immigrant (9.8%) population and indicates congenital CMV infection.     

Effect of levamisole on the course of chronic cytomegalovirus infection in women

The therapeutic effect of orally given levamisole in the treatment of women with chronic cytomegalovirus infection was studied. The patients were examined serologically, cytologically, virologically; the factors of cell-mediated immunity were also studied. Oral therapy with levamisole resulted in a definite increase of the cell-mediated immunity with a trend for decrease in antibody titres and reduced virus excretion. Evaluation of the clinical effect of levamisole therapy, however, revealed no distinct difference in the outcomes of pregnancy in the groups of women treated or not treated with levamisole.     

Production of monolayer cultures of amphibian tissues and their use for cultivation of vaccinia and measles viruses

Summary Methods were derived for obtaining trypsinized tissue cultures of cold-blooded animals, frogs and their tadpoles. After infecting these cellular structures with vaccinia and measles viruses no distinct cytopathic effect was obtained and no multiplication of these viruses was noted.Presented by Active Member AMN SSSR, V. M. Zhdanov Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 57, No. 1, pp. 123–125, January, 1964