全文获取类型
收费全文 | 314篇 |
免费 | 15篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 15篇 |
妇产科学 | 1篇 |
基础医学 | 46篇 |
口腔科学 | 7篇 |
临床医学 | 20篇 |
内科学 | 111篇 |
皮肤病学 | 5篇 |
神经病学 | 12篇 |
特种医学 | 42篇 |
外科学 | 13篇 |
综合类 | 9篇 |
预防医学 | 22篇 |
眼科学 | 1篇 |
药学 | 12篇 |
中国医学 | 2篇 |
肿瘤学 | 15篇 |
出版年
2022年 | 3篇 |
2021年 | 2篇 |
2020年 | 2篇 |
2019年 | 7篇 |
2018年 | 3篇 |
2017年 | 7篇 |
2016年 | 2篇 |
2015年 | 9篇 |
2014年 | 8篇 |
2013年 | 12篇 |
2012年 | 8篇 |
2011年 | 7篇 |
2010年 | 22篇 |
2009年 | 8篇 |
2008年 | 13篇 |
2007年 | 9篇 |
2006年 | 6篇 |
2005年 | 18篇 |
2003年 | 2篇 |
2001年 | 2篇 |
1999年 | 7篇 |
1998年 | 12篇 |
1997年 | 12篇 |
1996年 | 19篇 |
1995年 | 14篇 |
1994年 | 14篇 |
1993年 | 15篇 |
1992年 | 3篇 |
1990年 | 2篇 |
1989年 | 8篇 |
1988年 | 10篇 |
1987年 | 9篇 |
1986年 | 7篇 |
1985年 | 9篇 |
1984年 | 5篇 |
1983年 | 4篇 |
1981年 | 4篇 |
1980年 | 6篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 4篇 |
1976年 | 3篇 |
1975年 | 2篇 |
1966年 | 1篇 |
1959年 | 2篇 |
1954年 | 1篇 |
1949年 | 1篇 |
1931年 | 1篇 |
1919年 | 1篇 |
1889年 | 1篇 |
排序方式: 共有335条查询结果,搜索用时 15 毫秒
101.
Dehkordi O Haxhiu MA Millis RM Dennis GC Kc P Jafri A Khajavi M Trouth CO Zaidi SI 《Respiratory physiology & neurobiology》2004,141(1):21-34
In the present study, we determined whether alpha-7 subunit containing nicotinic acetylcholine receptors (nAChRs) are expressed by neurons within the pre-Botzinger complex (pre-BotC), bulbospinal, and phrenic motor nuclei in the rat. alpha-7 Immunohistochemistry combined with cholera toxin B (CTB), a retrograde tracer was used to detect expression of alpha-7 nAChRs by phrenic motor and bulbospinal neurons. Neurokinin-1 receptor immunoreactivity was used as a marker for pre-BotC neurons. Of the CTB-positive neurons in the phrenic nuclei, 60% exhibited immunoreactivity for alpha-7 nAChRs. Of the bulbospinal neurons in the paramedian reticular nuclei (PMn), gigantocellular nuclei (Gi), raphe nuclei, rostral ventrolateral medulla (RVLM) and nucleus tractus solitarius, 20-50% were found to express alpha-7 nAChR immunoreactivity. Of the peudorabies virus (PRV) labeled bulbospinal neurons in PMn, Gi, raphe and RVLM, 9-12% co-expressed alpha-7 nAChRs. Immunoreactivity for alpha-7 nAChRs was also detected in 57% of the neurokinin-1 receptor containing neurons presumed to reside in pre-BotC. These findings suggest that nicotinic cholinergic regulation of the chest wall pumping muscles may occur at multiple levels of the central nervous system. 相似文献
102.
103.
The incidence of neutralizing isoantibody formation to infused factor VIII in a cohort of 67 hemophilia A patients, born between January 1, 1971 and April 30, 1990, who had been treated exclusively with lyophilized cryoprecipitate, was 6% (5.3 per 1,000 patient years of observation). The age-dependent cumulative risk was 4.6% at 4 years of age and 6.7% at 8 years of age. Recent reports in patients treated with a variety of more pure concentrates show a much higher incidence of inhibitor formation and tend to be used as a reference when new concentrates are introduced. We believe that a patient group, such as the one studied here, is a more suitable reference population because these patients have been exclusively treated with a single factor VIII preparation. 相似文献
104.
Nemunaitis J; Appelbaum FR; Singer JW; Lilleby K; Wolff S; Greer JP; Bierman P; Resta D; Campion M; Levitt D 《Blood》1993,82(11):3273-3278
Recombinant human interleukin-3 (rhIL-3) was administered to 30 patients undergoing autologous bone marrow transplant (ABMT) for treatment of lymphoma. In this phase I dose escalation study, rhIL-3 was administered from day 0 to 20 after ABMT by 2-hour intravenous infusion at dose levels of 1, 2, 5, and 10 micrograms/kg/d. Seventeen patients did not complete therapy with rhIL-3. Eleven requested early discontinuation for malaise, confusion, transplant complications, or rapid engraftment and were removed from the study, whereas six patients developed grade III toxicity, including fever (three patients), or headache (three patients) possibly attributable to rhIL3. Other common toxicities included diarrhea, rigors, mucositis, and rash. The maximum tolerated dose of rhIL-3 was 2 micrograms/kg/d. No evidence of earlier hematopoietic cell recovery was observed compared with similar historical patients treated with recombinant human granulocyte- macrophage colony-stimulating factor. Future trials will be needed to determine alternate schedules of administration of rhIL-3 or the use of rhIL-3 in combination or in sequence with other growth factors. 相似文献
105.
Posterior atlantooccipital subluxation in Down syndrome 总被引:3,自引:0,他引:3
Three Down syndrome patients with posterior atlantooccipital (AO) subluxation are described. All are asymptomatic. The subluxation becomes manifest during active extension of the neck and reduces in flexion. Methods of assessing posterior AO subluxation are discussed. The abnormality is attributed to ligamentous laxity in patients with Down syndrome. 相似文献
106.
107.
FR Balkwill DB Griffin HA Band PCL Beverley 《The Journal of experimental medicine》1983,157(3):1059-1063
We have described in this paper a novel human interferon (IFN) with antigenic and cross-species reactivity of α-IFN and physicochemical properties of γ-IFN. This IFN is produced by normal peripheral blood mononuclear cells during an immune response but has also been associated with autoimmune disease (10). The system described here will be useful in elucidating the biological significance and cell of origin of this IFN. 相似文献
108.
109.
GEORGE D. VEENHUYZEN M.D. SÉBASTIEN KNECHT M.D. MARK D. O’NEILL M.B.B.Ch. D. Phil. MATTHEW WRIGHT M.B.B.S. Ph.D. ISABELLE NAULT M.D. WEERASOORIYA RUKSHEN M.B.B.S. SHINSUKE MIYAZAKI M.D. FRÉDÉRIC SACHER M.D. MÉLÈZE HOCINI M.D. PIERRE JAÏS M.D. MICHEL HAÏSSAGUERRE M.D. 《Pacing and clinical electrophysiology : PACE》2009,32(3):393-398
110.
Saied Habibian Dehkordi Amin Bigham Sadegh Ehsan Abaspour Nasim Beigi Brojeni Ehsan Aali Ehsan Sadeghi 《Comparative clinical pathology》2012,21(3):289-293
Tramadol is a synthetic, centrally acting opioid analgesic. This drug is a μ-opioid agonist that also inhibits the reuptake of noradrenaline and serotonin. The present study was carried out to investigate the effects of this drug on blood profile, hepatic enzymes activities and blood urea nitrogen (BUN) in sheep. For this purpose, ten healthy non-pregnant Lory ewes were used. Before the experiment, three blood samples were taken from the jugular vein as a control; ewes were then randomly divided into two groups. The test group was given tramadol IV (5?mg/kg) for five consecutive days; group 2, the sham group, was given normal saline IV (5?mg/kg) for the same time period. The results of present study showed that short-term injection of tramadol causes significant change in red blood cell count and packed cell volume value. However, level of serum activities of hepatic enzymes and BUN remained unaltered. In conclusion, these results suggest that although short-term use of tramadol may have no toxic effects on the liver and kidney, its effects on the blood profile should be kept in mind. 相似文献