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目的:间充质干细胞具有强大的增殖能力和多向分化潜能,文章对其主要的来源途径予以综述。资料来源:应用计算机检索Medline1991-01/2006-01期间的相关文章,检索词为“mesenchyma stem cells,origin,research progress”,并限定文章语言种类为English。同时计算机检索中国期刊全文数据库1998-01/2006-10期间的相关文章,检索词为“间充质干细胞,来源,研究进展”,并限定文章语言种类为中文。资料选择:对资料进行初审,并查看每篇文献后的引文。纳入标准:①间充质干细胞的起源。②间充质干细胞研究进展、干细胞的分离及鉴定。排除标准:重复研究、个案报告或Meta分析类文章。资料提炼:共收集到96篇相关文献,40篇文献符合纳入标准,排除的56篇文献为内容陈旧或重复。符合纳入标准的40篇文献中,分别涉及骨髓、肌肉、脐血、胎盘、外周血、脂肪组织、血管及其他来源的间充质干细胞。资料综合:间充质干细胞是属于中胚层的一类多能干细胞,具有强大的增殖能力和多向分化潜能,动物模型试验和临床应用研究也取得了一定的效果。间充质干细胞来源广泛,易于获得,临床上为神经损伤及其他系统的损伤修复提供了更为广泛的途径。结论:间充质干细胞主要来源于骨髓、肌肉、脐血、外周血、胎盘等组织,具有广阔的应用前景。 相似文献
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R Berner RF Schumacher S Hameister J forster 《Acta paediatrica (Oslo, Norway : 1992)》1999,88(S426):48-52
The need for a rotavirus vaccine in any particular country depends primarily on the number of hospitalized cases. Since only limited data are available for Germany, we undertook a retrospective hospital-based analysis in order to gather further information. From 1987 through 1996, a total of 3618 inpatients were hospitalized with a diagnosis of gastroenteritis (ICD 9). In 892 (25%) of them the causative organism wasa rotavirus. During the same period, 1886 (out of 8383; 22%) stool speciment tested in the hospital laboratory were obtained from rotavirus-positive inpatients. In 49.2% the infection was community-acquired, and in the remainder of nosocomial origin. Infants under 4 months of age(n=709; 38%) predominated among both the nosocomial and community-acquired infections. Premature neonates made up 26% of the nosocomial, but only 2% of the community-acquired cases of diarrhoea. The winter peak (January) was most pronounced in the age group 4-12 months, but in those more than 1 y old the peak came a month later. The median hospitalization time for community-acquired cases was 4 d (mean 5.9 d).The mortality was 0.1%. Rotavirus infection must therefore be regarded as a considerable burden, particularly with regard to infants and young children. Furthermore, the morbidity due to nosocomial infection with the rotavirus, analysed here in a long-term observational study, is unexpectedly high. □ Hospital-based study, nosocomial infection, rotavirus 相似文献
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Cerebral blood flow relationships associated with a difficult tone recognition task in trained normal volunteers 总被引:2,自引:2,他引:0
Holcomb HH; Medoff DR; Caudill PJ; Zhao Z; Lahti AC; Dannals RF; Tamminga CA 《Cerebral cortex (New York, N.Y. : 1991)》1998,8(6):534-542
Tone recognition is partially subserved by neural activity in the right
frontal and primary auditory cortices. First we determined the brain areas
associated with tone perception and recognition. This study then examined
how regional cerebral blood flow (rCBF) in these and other brain regions
correlates with the behavioral characteristics of a difficult tone
recognition task. rCBF changes were assessed using H2(15)O positron
emission tomography. Subtraction procedures were used to localize
significant change regions and correlational analyses were applied to
determine how response times (RT) predicted rCBF patterns. Twelve trained
normal volunteers were studied in three conditions: REST, sensory motor
control (SMC) and decision (DEC). The SMC-REST contrast revealed bilateral
activation of primary auditory cortices, cerebellum and bilateral inferior
frontal gyri. DEC-SMC produced significant clusters in the right middle and
inferior frontal gyri, insula and claustrum; the anterior cingulate gyrus
and supplementary motor area; the left insula/claustrum; and the left
cerebellum. Correlational analyses, RT versus rCBF from DEC scans, showed a
positive correlation in right inferior and middle frontal cortex; rCBF in
bilateral auditory cortices and cerebellum exhibited significant negative
correlations with RT These changes suggest that neural activity in the
right frontal, superior temporal and cerebellar regions shifts back and
forth in magnitude depending on whether tone recognition RT is relatively
fast or slow, during a difficult, accurate assessment.
相似文献