全文获取类型
收费全文 | 8055篇 |
免费 | 662篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 125篇 |
儿科学 | 329篇 |
妇产科学 | 156篇 |
基础医学 | 1024篇 |
口腔科学 | 67篇 |
临床医学 | 1298篇 |
内科学 | 1475篇 |
皮肤病学 | 183篇 |
神经病学 | 722篇 |
特种医学 | 132篇 |
外科学 | 925篇 |
综合类 | 178篇 |
一般理论 | 9篇 |
预防医学 | 864篇 |
眼科学 | 109篇 |
药学 | 502篇 |
中国医学 | 5篇 |
肿瘤学 | 637篇 |
出版年
2023年 | 62篇 |
2022年 | 52篇 |
2021年 | 223篇 |
2020年 | 99篇 |
2019年 | 207篇 |
2018年 | 245篇 |
2017年 | 168篇 |
2016年 | 191篇 |
2015年 | 200篇 |
2014年 | 262篇 |
2013年 | 421篇 |
2012年 | 564篇 |
2011年 | 589篇 |
2010年 | 298篇 |
2009年 | 270篇 |
2008年 | 463篇 |
2007年 | 485篇 |
2006年 | 442篇 |
2005年 | 503篇 |
2004年 | 439篇 |
2003年 | 437篇 |
2002年 | 362篇 |
2001年 | 131篇 |
2000年 | 115篇 |
1999年 | 113篇 |
1998年 | 83篇 |
1997年 | 71篇 |
1996年 | 56篇 |
1995年 | 72篇 |
1994年 | 53篇 |
1993年 | 41篇 |
1992年 | 81篇 |
1991年 | 65篇 |
1990年 | 69篇 |
1989年 | 50篇 |
1988年 | 50篇 |
1987年 | 47篇 |
1986年 | 44篇 |
1985年 | 46篇 |
1984年 | 33篇 |
1983年 | 26篇 |
1979年 | 23篇 |
1978年 | 23篇 |
1974年 | 26篇 |
1972年 | 22篇 |
1971年 | 22篇 |
1970年 | 29篇 |
1969年 | 30篇 |
1968年 | 23篇 |
1967年 | 26篇 |
排序方式: 共有8740条查询结果,搜索用时 46 毫秒
21.
22.
23.
24.
25.
26.
Several underlying metabolic abnormalities may be present in patients with recurrent calcium calculus disease (RCCD). The aim of this study was to determine the prevalence of deficiencies of 2 well-known potent inhibitors of crystal formation and growth, citrate and pyrophosphate, in the various metabolic subgroups and as single defects. In 107 patients with RCCD, urinary citrate was significantly decreased in all metabolic subgroups with 49% of patients having hypocitraturia (2.53 +/- 1.19 mmol/24 h) versus controls (3.44 +/- 0.96 mmol/24 h; p less than 0.001). Reduced pyrophosphate:creatinine ratios were present in all the patient subgroups, and 48% of all patients had reduced ratios (1.68 +/- 1.68 vs. 3.10 +/- 2.66 in controls; p less than 0.01). There was no correlation between citrate and pyrophosphate concentration. Isolated hypocitraturia was found in 11.2%, reduced pyrophosphate:creatinine ratios as the single defect in 11.2% and a combination of both in 12.1% of patients. Thus inhibitor defects play an important role in patients with RCCD and frequently occur as isolated biochemical defects. 相似文献
27.
28.
Christopher L. Knight MD Henry A. Sakowski MD Bruce L. Houghton MD Mary B. Laya MD MPH Dawn E. DeWitt MD MSc 《Journal of general internal medicine》2004,19(5P2):594-598
The World Wide Web creates new challenges and opportunities for medical educators. Prominent among these are the lack of consistent standards by which to evaluate web-based educational tools. We present the instrument that was used to review web-based innovations in medical education submissions to the 2003 Society of General Internal Medicine (SGIM) national meeting, and discuss the process used by the SGIM web-based clinical curriculum interest group to develop the instrument. The 5 highest-ranked submissions are summarized with commentary from the reviewers. 相似文献
29.
Dawn Hastreiter MD PhD ; Jeannie Chao BS ; QI Wang MD ; Richard M. Ozuna MD ; Myron Spector PhD 《Wound repair and regeneration》2004,12(4):430-438
That a contractile actin isoform has been found in cells of other cartilage tissues in healing and disease states prompted this investigation of the presence of alpha-smooth muscle actin (alpha-SMA) in pathological human intervertebral disc tissue. The presence of this isoform has been reported in human intervertebral disc specimens obtained at autopsy from subjects for whom there were no reported symptoms. An objective of this study was to evaluate the cell density and percentage of alpha-SMA-containing cells in pathological nucleus pulposus tissue obtained from lumbar disc surgery from 17 patients. Additionally, explants of nucleus pulposus material were cultured to determine how alpha-SMA expression changed with time in vitro. Seventy-six 5-mm diameter explants (approximately 2 mm thick) pooled from six lumbar surgeries were cultured for 1, 2, 4, or 6 weeks. Microtomed sections of paraffin-embedded specimens were stained with hematoxylin and eosin or a monoclonal antibody to alpha-SMA. Histologically, cells were categorized as to alpha-SMA phenotype (positive or negative), and the areal cell density was determined. The evaluation of the cultured nucleus pulposus explants also included documentation of the percentage of cells that were round or elongated and the percentage of the cells that were part of a group (group: >/= 2 cells). Every nucleus pulposus section exhibited the presence of alpha-SMA-containing cells, which accounted for approximately 24 percent of the cells in vivo. In vivo, the cell density was significantly higher in older individuals (p = 0.02). The average time for cell outgrowth from the explants was 8.6 days. Approximately 10-15 percent of the cells in the explants stained positive for alpha-SMA. The time in culture had no significant effect on any of the outcome measures except the percentage of alpha-SMA-containing cells that were round (p = 0.008), with values decreasing through 4 weeks and then slightly rising at 6 weeks. The role of alpha-SMA in intervertebral disc pathology warrants further investigation. 相似文献
30.
Bacteraemia in diabetics 总被引:1,自引:0,他引:1
I.A. MacFarlane R.M. Brown R.W. Smyth D.W. Burdon M.G. Fitzgerald 《The Journal of infection》1986,12(3):213-219
During a period of 22 months one or more episodes of bacteraemia were detected in 168 patients in hospital. Of these, 29% also had diabetes compared with 10% of the total number of patients admitted to hospital during this time (P less than 0.001). The diabetics with bacteraemia were elderly and diabetes had usually been present for many years. Most of them were not receiving insulin at the time bacteraemia was diagnosed. Escherichia coli was the commonest pathogen (33%) in the diabetics, the main source of infection being the urinary tract. This finding may be due to diabetic autonomic neuropathy, which leads to a poorly emptying, chronically infected bladder. Urinary tract infections with bacteraemia in elderly diabetics are often accompanied by vague non-specific symptoms and poor diabetic control. Fever is infrequent. Prompt antibiotic therapy and insulin injections to control the diabetes usually cure these serious infections. 相似文献