首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   251279篇
  免费   18356篇
  国内免费   1203篇
耳鼻咽喉   2784篇
儿科学   6520篇
妇产科学   4592篇
基础医学   32919篇
口腔科学   4560篇
临床医学   25345篇
内科学   53474篇
皮肤病学   3398篇
神经病学   24253篇
特种医学   8486篇
外国民族医学   11篇
外科学   38433篇
综合类   3475篇
一般理论   318篇
预防医学   21319篇
眼科学   6552篇
药学   16996篇
  6篇
中国医学   362篇
肿瘤学   17035篇
  2023年   1209篇
  2022年   2029篇
  2021年   5437篇
  2020年   3261篇
  2019年   5301篇
  2018年   5952篇
  2017年   4472篇
  2016年   4960篇
  2015年   5836篇
  2014年   8612篇
  2013年   11801篇
  2012年   18012篇
  2011年   18901篇
  2010年   10580篇
  2009年   9437篇
  2008年   16595篇
  2007年   17501篇
  2006年   17306篇
  2005年   17288篇
  2004年   16188篇
  2003年   15040篇
  2002年   14055篇
  2001年   2105篇
  2000年   1603篇
  1999年   2323篇
  1998年   3087篇
  1997年   2591篇
  1996年   2208篇
  1995年   2117篇
  1994年   1762篇
  1993年   1585篇
  1992年   1260篇
  1991年   1156篇
  1990年   1006篇
  1989年   983篇
  1988年   980篇
  1987年   951篇
  1986年   960篇
  1985年   975篇
  1984年   1221篇
  1983年   1128篇
  1982年   1377篇
  1981年   1324篇
  1980年   1154篇
  1979年   706篇
  1978年   753篇
  1977年   640篇
  1976年   592篇
  1975年   477篇
  1974年   472篇
排序方式: 共有10000条查询结果,搜索用时 437 毫秒
991.
BACKGROUND: Providing patients with an audiotape of their medical consultation has been a relatively common practice in oncology clinics for some years. However, broader generalisability of the technique has yet to be examined. AIMS: To investigate the efficacy of providing patients with an audiotape of their consultation in a general practice setting. DESIGN OF STUDY: Randomised controlled trial: 95 experimental participants, 85 controls. SETTING: Routine surgeries run by two general practitioners (GPs) in two different health centres. METHOD: All patients attending GP appointments were eligible for inclusion. Patients were followed up by telephone 7-10 days later. RESULTS: More than half (61%) of the patients who received a tape listened to it. Among listeners, 64% rated the tape useful or very useful; 24% noticed information not heard in the consultation. Half of listeners (46%) said that their understanding of the consultation improved after listening to the tape. Half of the listeners (48%) shared the tape with others, of whom 71% found sharing helpful or very helpful. However, 21% of those who shared the information with others found this unhelpful or very unhelpful, suggesting that patients may need to be briefed on the potential risks of sharing. At follow-up a week later, it emerged that being given a tape had no effect on adherence with GPs' advice, nor on anxiety about conditions. CONCLUSION: Providing patients with an audiotape of their GP consultation was positively rated by many patients. Although there were no detectable clinical effects at follow-up, the technique merits further evaluation in general practice.  相似文献   
992.
993.
994.
This study evaluated a multiple‐family group‐intervention program (MFGI) for first‐time juvenile offenders. The recidivism rate for subjects who completed the MFGI (the Family Solutions Program) was compared to recidivism rates of two other groups of first‐time juvenile offenders. Using logistic regression analysis predicting who will recidivate, juvenile first offenders who were placed on probation (N = 95) were 9.3 times more likely to re‐offend compared to the Family Solutions Program (FSP) graduates (N = 267). Families referred to FSP but who dropped out (most never attended the 10 session program) (N = 93) also were 4.4 times more likely to re‐offend compared to FSP graduates. An intent‐to‐treat model comparing the combined group of FSP graduates and dropouts with the probation group indicated that a youth in the probation group was 8.1 times more likely to re‐offend than a youth referred to the FSP. Results indicating better outcomes on recidivism for FSP graduates were significant for both male and female youths. Implications for policy and practitioners are discussed. © 2004 Wiley Periodicals, Inc. J Comm Psychol 32: 177–200, 2004.  相似文献   
995.
Introduction In combination with the catalytic domain, the ancillary domains of the ADAMTS' are proposed to regulate activity via interactions with sulfated GAGs, the extracellular matrix (ECM) and cell surface. Interactions with both GAGs and the ECM have been attributed to the thrombospondin (TSP) type 1 motifs and spacer region ( Kuno and Matsushima 1998 ; Flannery et al. 2002 ). ADAMTS‐1, ‐4 and ‐5, all undergo cleavage within their respective spacer regions ( Flannery et al. 2002 ; Rodriguez‐Manzaneque et al. 2000 ; Georgiadis et al. 2002 ), an event which has been reported to increase activity towards the interglobular domain of aggrecan and decrease the heparin affinity of ADAMTS‐4 ( Flannery et al. 2002 ; Gao et al. 2002 ). Materials and methods V5‐ and His‐tagged recombinant human ADAMTS‐4 constructs terminating after the catalytic (?DTS), disintegrin‐like (?TS), TSP (?S) or spacer region (Full) were expressed in High‐Five cells. Proteoglycanase activities of the resultant proteins were assayed with solution digests of aggrecan and a polyacrylamide‐entrapped aggrecan particle assay. Proteolytic activity was measured using a novel, nonglycosylated, reporter substrate assay. Results All forms of ADAMTS‐4 were active to varying degrees in the reporter substrate assay. Digestion of aggrecan in solution digests was apparent in all proteins with the exception of the catalytic domain in isolation (?DTS). Activity towards aggrecan decreased with increasing truncation of the protein. Discussion Removal of the cysteine‐rich‐spacer domain and further C‐terminal truncations decrease the activity of ADAMTS‐4 towards aggrecan, whilst the proteolytic activity remains intact. Cleavages releasing the ancillary domains of ADAMTS' may therefore alter the catalytic activity of these enzymes against proteoglycans and also nonglycosylated polypeptides. More information is required about potential substrates for the processed forms of ADAMTS‐4.  相似文献   
996.
997.
Objective   To profile the expression of all known members of the matrix metalloproteinase ( MMP ), a disintegrin and metalloproteinase with thrombospondin motifs ( ADAMTS ), and tissue inhibitor of metalloproteinases ( TIMP s) gene families in normal cartilage and that from patients with osteoarthritis (OA).
Methods   Human cartilage was obtained from femoral heads at joint replacement for either osteoarthritis or following fracture to the neck of femur. Total RNA was purified and expression of genes assayed using quantitative real-time PCR.
Results   Several members of the above gene families were regulated in OA. Genes increasing in expression in OA were: at P  < 0.001, MMP-13 , MMP-28 , ADAMTS-16 ; at P  < 0.01, MMP-9 , MMP-16 , ADAMTS-2 , ADAMTS-14 and at P  < 0.05, MMP-2 , TIMP-3 , ADAMTS-12 . Genes decreasing in expression in OA were: at P  < 0.001, MMP-1 , MMP-3 , ADAMTS-1 ; at P  < 0.01, MMP-10 , TIMP-1 , ADAMTS-9 and at P  < 0.05, TIMP-4 , ADAMTS-5 , ADAMTS-15 . Correlation analysis revealed that groups of genes across the gene families are co-expressed in cartilage.
Conclusion   This is the first comprehensive expression profile of all known MMP , ADAMTS and TIMP genes in cartilage. Patterns of expression provide a foundation on which to understand mechanisms of gene regulation in OA and potentially for refining the specificity of anti-proteolytic therapies.  相似文献   
998.
999.
1000.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号