全文获取类型
收费全文 | 613篇 |
免费 | 33篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 6篇 |
妇产科学 | 9篇 |
基础医学 | 120篇 |
口腔科学 | 23篇 |
临床医学 | 61篇 |
内科学 | 99篇 |
皮肤病学 | 5篇 |
神经病学 | 61篇 |
特种医学 | 52篇 |
外科学 | 75篇 |
综合类 | 17篇 |
一般理论 | 1篇 |
预防医学 | 31篇 |
眼科学 | 4篇 |
药学 | 50篇 |
肿瘤学 | 37篇 |
出版年
2024年 | 1篇 |
2023年 | 6篇 |
2022年 | 12篇 |
2021年 | 25篇 |
2020年 | 14篇 |
2019年 | 12篇 |
2018年 | 17篇 |
2017年 | 10篇 |
2016年 | 23篇 |
2015年 | 24篇 |
2014年 | 27篇 |
2013年 | 33篇 |
2012年 | 53篇 |
2011年 | 42篇 |
2010年 | 34篇 |
2009年 | 23篇 |
2008年 | 44篇 |
2007年 | 44篇 |
2006年 | 40篇 |
2005年 | 29篇 |
2004年 | 31篇 |
2003年 | 28篇 |
2002年 | 24篇 |
2001年 | 7篇 |
2000年 | 5篇 |
1999年 | 1篇 |
1998年 | 3篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1995年 | 3篇 |
1994年 | 3篇 |
1992年 | 3篇 |
1991年 | 4篇 |
1990年 | 3篇 |
1989年 | 2篇 |
1988年 | 4篇 |
1987年 | 2篇 |
1986年 | 6篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1979年 | 1篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1965年 | 1篇 |
1964年 | 1篇 |
排序方式: 共有653条查询结果,搜索用时 281 毫秒
71.
Zibin Jiang Joanne Haughan Kaitlyn L. Moss Darko Stefanovski Kyla F. Ortved Mary A. Robinson 《Drug testing and analysis》2022,14(5):963-972
Gene therapy is currently prohibited in human and equine athletes and novel analytical methods are needed for its detection. Most in vivo products use non-integrating, recombinant viral vectors derived from adeno-associated virus (AAV) to deliver transgenes into cells, where they are transcribed and translated into functional proteins. Although the majority of wild-type AAV (WTAAV) DNA is removed from recombinant AAV (rAAV) vectors, some sequences are conserved. The goal of this study was to develop a quantitative polymerase chain reaction (QPCR) screening test targeting conserved AAV sequences to enable theoretical detection of all rAAV gene therapy products, regardless of encoded transgenes while excluding the presence of WTAAV DNA in horses. Primer sets were developed and validated to target an AAV2 sequence highly conserved across rAAV viral vectors and a sequence only found in wild type AAV2 (WTAAV2). Six horses were administered an intra-articular injection of rAAV. Plasma and synovial fluid were collected on days 0, 1, 2, 4, 7, 14, 28, 56, and 84. Using QPCR, rAAV was detected in plasma for up to 2–4 days in all horses. rAAV DNA was detected for 28 days in synovial fluid from two horses for which synovial fluid samples were available. No WTAAV2 DNA was detected in any sample. This is the first study to develop a QPCR test capable of screening for rAAV vectors that may be used for gene doping in horses. 相似文献
72.
Countertransference in the therapy of suicidal patients - an important part of integrative treatment
Marcinko D Skocić M Sarić M Popović-Knapić V Tentor B Rudan V 《Psychiatria Danubina》2008,20(3):402-405
One of the central issues in the psychotherapy of suicidal patients is the countertransference. Key concepts in countertransference include projective identification, role-responsiveness and countertransference enactment. It is important to recognize that countertransference can be effective in understanding the emotional intensity of the suicidal person's internal world. There is a significant relationship between treatment outcome and the different countertransference feelings among the therapists. In this paper we have illustrated important factors for understanding psychiatrist's countertransference reactions when working with suicidal patients. 相似文献
73.
An example which confirmes the adequacy of the integrative perspective in medicine is depression in dermatology because of the sufficient number of arguments linking depression and some chronic skin conditions in depth more than simply comorbidity. In recent literature, the authors found, how depression in dermatology occurs significantly more frequently than in the general population. In dermatological patients the prevalence of depression is around 30% which is more in comparison to patients in general practice where prevalence of depression is 22%. The authors found a considerable similarity in the various characteristics between depression and psoriasis, based upon recent research findings in immunity disorder and elevated concentrations of proinflammatory cytokines as well as acute phase proteins in both disorders, indicating that both disorders can be considered as immunologicaly mediated, inflammatory states with repetitive chronic progress and similar comorbidity. The afore mentioned theoretical settings evoke the integrative aspect and the integrative interdisciplinary approach placing in the center of attention not only the diseased person with his fears, needs, preocupations and expectations during treatment, but the person who is at risk of becoming burdened with these disorders. 相似文献
74.
75.
76.
Ivo Juri Dragan Primorac ivojin agar Mihovil Bioc Sinia Pav Dubravko Furlan Drzen Budimir Stpan Jankovi Petar Kreimir Hodi Darko Alfirevi Antonio Alujevi Marina Titli 《Pediatrics international》2001,43(2):152-156
BACKGROUND: Acute appendicitis is the most common condition requiring an emergency abdominal operation in childhood. In the present study, we analyzed the frequency of portal and systemic bacteremia in 42 patients with acute appendicitis and determined the microbial agents responsible for an acute appendicitis and for portal and systemic bacteremia. METHODS: Appendectomies were performed on 50 young patients (5-18 years of age), as well as clinical and bacteriological tests. Six independent samples from each patient isolated from the peripheral vein, superior mesenteric vein, appendix and peritoneum were obtained prior to surgery, during surgery and after surgery for biochemical, immunologic and bacteriologic examination. RESULTS: Pathohistology confirmed the diagnosis of appendicitis in 42 patients, while in the other eight patients there were no obvious pathologic findings, so they served as a control group. Of 50 patients with a clinical appearance of acute appendicitis, in 19 patients (38%) we detected portal bacteremia in the mesenteric vein, while in only three cases (6%) did we find systemic bacteremia detected from the peripheral vein. Furthermore, bacteriologic analysis revealed that Bacteroides spp. and Escherichia coli were the predominant species isolated. CONCLUSIONS: The results presented in this paper suggests that portal bacteremia did not influence peripheral blood reactions. Furthermore, in the present study we have found a positive correlation between the smear and bacteremia of the superior mesenteric vein, but not with the bacteremia of systemic blood. 相似文献
77.
78.
Natalie Darko 《Journal of Men's Health》2009,6(4):331-337
BackgroundResearch has shown that those men who are dissatisfied with their bodies will mask these concerns in sports practices. Accordingly, men's body dissatisfactions often go unrecognised because the practices drawn upon to conceal them are perceived as customary forms of public masculine behaviour. This paper examines whether a group of British Rugby Union men, aged 18–30 of varied ethnic origin, participating in a 1st XV Team at a British university, experience body anxieties and use rugby and health-related sports acts to overcome and conceal them. It moves away from some of the existing methods used in clinical and sociological research to examine men's body dissatisfactions as it combines collaborative visual research methods with conventional qualitative methods to examine these men's anxieties.MethodsCollaborative photography and in-depth photo-elicitation interviews were conducted with 10 men participating in an elite university Rugby Union team in the United Kingdom.ResultsThe rugby men expressed varying degrees of body anxiety and used the sport, and health-related practices, to conceal these concerns. Visual research methods combined with conventional qualitative methods made it easier for these men to verbalise their body anxieties in more intimate dimensions of the sport.ConclusionsThese findings show that these men experience body anxieties, yet there are limited intimate dimensions for these men to express them in Rugby Union, without ramifications for their masculine identity and sports performance. More research is needed to examine these dimensions as they are significant for understanding rugby men's body anxieties and the impact their relationships with other rugby men have to these concerns. The implications are that visual research methods could be used in clinical research, assessment and treatment interventions, as they might assist in encouraging other sportsmen to express these concerns. 相似文献
79.
Ofei F Darko R Appiah-Kusi J Aduful H Baddoo H Adu-Gyamfi Y Tettey Y Gyasi R Aleksenko L Yeboah E Arc-Hampong E Yeboah A Ogoe E 《Ghana medical journal》2007,41(2):82-87
SummaryAlthough endocrine causes of secondary hypertension are relatively uncommon, medical practitioners must maintain a high index of suspicion for them in certain categories of patients. Such patients include young individuals, those with difficult-to-treat hypertension and those presenting with symptoms, clinical signs and/or laboratory parameters well-known to be associated with Cushing's syndrome, Conn's syndrome or phaeochromocytoma.This paper reports on 5 patients identified over a 2-year period with various hormonally-active adrenal adenomas causing hypertension in an environment where, hitherto, the occurrence of these conditions was generally thought to be rare. Aspects of the patients' histories, examination and laboratory findings that drew attention to the possibility of the diagnosis in each case are highlighted, as are the confirmatory investigations and management methods used by a multidisciplinary team of medical practitioners. The clinical outcome with appropriate treatment of adrenal-related hypertension is good and can result in significant cost savings in the long term. 相似文献
80.
Tina Becic Darko Kero Katarina Vukojevic Snjezana Mardesic Mirna Saraga-Babic 《Acta histochemica》2018,120(3):205-214