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Primoz̆ Strojan MD Alfio Ferlito MD Jesus E. Medina MD Julia A. Woolgar FRCPath Alessandra Rinaldo MD K. Thomas Robbins MD Johannes J. Fagan MBChB William M. Mendenhall MD Vinidh Paleri MS Carl E. Silver MD Kerry D. Olsen MD June Corry MD Carlos Suárez MD Juan P. Rodrigo MD Johannes A. Langendijk MD Kenneth O. Devaney MD Luiz P. Kowalski MD Dana M. Hartl MD Missak Haigentz Jr MD Jochen A. Werner MD Phillip K. Pellitteri DO Remco de Bree MD Gregory T. Wolf MD Robert P. Takes MD Eric M. Genden MD Michael L. Hinni MD Vanni Mondin MD Ashok R. Shaha MD Leon Barnes MD 《Head & neck》2012,34(12):1820-1821
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AimsTo determine whether pioglitazone 30 mg daily reduces levels of ADMA in adult patients with diabetes, and whether there is improvement in markers of oxidative stress.MethodsProspective randomized cross-over placebo-controlled study of 36 adults age 40–75 years with type 2 diabetes recruited from a single academic health center. Intervention was for 12 weeks, followed by a 4-week wash-out period, followed by a second 12-week cross-over treatment period. The main outcome was comparison of the change in ADMA levels in the two treatment periods. Secondary outcomes included change in NOx and F2-isoprostanes.ResultsThirty-six patients were enrolled in the study, 31 completed the protocol; the study enrollment met the sample size required to detect a change of 18% in levels. There were no differences in ADMA, NOx and F2-isoprostanes levels in the two treatment periods. Non-study medication changes or changes in dose were infrequent, and a statin was added during the study period in only one patient.ConclusionsDespite previous animal data that showed an effect of pioglitazone on ADMA, the current study in human patients did not demonstrate any differences in ADMA, NOx, or F2-isoprostane levels. The results do not favor that pioglitazone has a significant impact on ADMA levels in human patients with diabetes. 相似文献
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In 2007, the VA Connecticut Healthcare System began a home electronic messaging programme for mental health patients. During the first two years, 76 patients with diagnoses of schizophrenia, post traumatic stress disorder, depression and substance-use disorders received a home messaging device, which was connected via an ordinary telephone line. There were daily questions, which were based on disease management protocols, and included alerts, data and educational components. Patient data were sent to a nurse practitioner each day for triage and follow-up. Patients used the device for at least six months. In the six months prior to enrolment, 42 patients were hospitalized for 46 admissions. In the following six months, six patients were hospitalized for nine admissions (P < 0.0001). In the six months prior to enrolment, 47 patients had a total of 80 ER visits. In the following six months, 16 patients had a total of 32 ER visits (P < 0.0001). Questionnaire responses indicated a high level of satisfaction with the home messaging programme. 相似文献
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