全文获取类型
收费全文 | 17715篇 |
免费 | 1144篇 |
国内免费 | 48篇 |
专业分类
耳鼻咽喉 | 231篇 |
儿科学 | 424篇 |
妇产科学 | 428篇 |
基础医学 | 2268篇 |
口腔科学 | 1115篇 |
临床医学 | 1342篇 |
内科学 | 3859篇 |
皮肤病学 | 371篇 |
神经病学 | 1495篇 |
特种医学 | 507篇 |
外国民族医学 | 1篇 |
外科学 | 2080篇 |
综合类 | 137篇 |
一般理论 | 6篇 |
预防医学 | 1708篇 |
眼科学 | 277篇 |
药学 | 1550篇 |
中国医学 | 124篇 |
肿瘤学 | 984篇 |
出版年
2023年 | 117篇 |
2022年 | 321篇 |
2021年 | 563篇 |
2020年 | 354篇 |
2019年 | 465篇 |
2018年 | 558篇 |
2017年 | 413篇 |
2016年 | 445篇 |
2015年 | 528篇 |
2014年 | 647篇 |
2013年 | 909篇 |
2012年 | 1180篇 |
2011年 | 1235篇 |
2010年 | 714篇 |
2009年 | 637篇 |
2008年 | 957篇 |
2007年 | 935篇 |
2006年 | 865篇 |
2005年 | 782篇 |
2004年 | 671篇 |
2003年 | 621篇 |
2002年 | 539篇 |
2001年 | 458篇 |
2000年 | 429篇 |
1999年 | 342篇 |
1998年 | 152篇 |
1997年 | 124篇 |
1996年 | 118篇 |
1995年 | 97篇 |
1994年 | 90篇 |
1993年 | 88篇 |
1992年 | 242篇 |
1991年 | 217篇 |
1990年 | 217篇 |
1989年 | 187篇 |
1988年 | 179篇 |
1987年 | 135篇 |
1986年 | 158篇 |
1985年 | 124篇 |
1984年 | 91篇 |
1983年 | 76篇 |
1982年 | 71篇 |
1981年 | 50篇 |
1980年 | 56篇 |
1979年 | 109篇 |
1978年 | 53篇 |
1977年 | 56篇 |
1976年 | 57篇 |
1975年 | 57篇 |
1974年 | 50篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
Marco Cirillo Andrea Amaducci Emmanuel Villa Margherita Dalla Tomba Federico Brunelli Zen Mhagna Giovanni Troise Eugenio Quaini 《Journal of cardiothoracic surgery》2006,1(1):40-11
Background
Long-term morphofunctional outcome may vary widely in surgical anterior left ventricular wall restoration, suggesting variability in post-surgical remodeling similar to that observed following acute myocardial infarction. The aim of this pilot study was to demonstrate that surgical restoration obtained with a particular shape of endoventricular patch leads to steady morphofunctional ventricular improvement when geometry, volume and residual akinesia can be restored as normal as possible. 相似文献32.
L Bonina M Carbone P Mastroeni G B Costa P Mastroeni 《Journal of chemotherapy (Florence, Italy)》1992,4(6):353-357
This study was undertaken to investigate the efficacy of rufloxacin, a new quinolone which is interesting due to its pharmacokinetics characterized by a long plasma half-life, in the treatment of systemic salmonella infections in the mouse typhoid model. Innately susceptible BALB/c and resistant CBA mice were used to investigate the efficacy of rufloxacin in controlling systemic salmonella infections when given for brief or prolonged periods. The present study shows that rufloxacin is not only very effective on both mouse strains, but can completely eradicate the salmonellae from livers and spleens when given early in the infection of CBA resistant mice. 相似文献
33.
The aim of the present study was to investigate the existence of alterations of the blood-brain barrier (BBB) permeability in rats injected with centrally acting drugs, by calculating a unidirectional blood-to-brain transfer constant (Ki) for the circulating tracer [14C]-alpha-aminoisobutyric acid. The intraperitoneal (i.p.) injection of the dopaminergic antagonist haloperidol (1 mg kg-1) did not modify the regional BBB permeability. When the cholinomimetic agent arecoline hydrobromide (6.25 mg kg-1) was injected i.p. into methylatropine-pretreated rats, it induced a significant decrease of Ki values within the frontal cortex, parietal cortex, striatum and brain-stem. Our findings emphasize two concepts: (1) centrally acting drugs, such as arecoline, can induce changes in the BBB permeability, through several mechanisms; (2) there is no predictable correlation of drug stimulation of specific brain neuronal pathways and changes in the permeability of the BBB. 相似文献
34.
O O Camponês do Brasil P A Pontes J Speck Filho H O Costa 《Revue de laryngologie - otologie - rhinologie》1991,112(1):45-53
The authors report on 14 patients with epidermoid carcinoma of the glottic region, classified T1, T2 and T3, operated upon by a hemilaryngectomy (9 cases) with reconstruction using a Plathysma myocutaneous flap. The oncological results over a follow-up period of 1 to 6 years and the functional results are analyzed. The authors conclude that this method does not compromise the carcinological result and provides a good functional result with low ratings for complications, with in addition an adequate support for the organ, favouring increased resections. 相似文献
35.
36.
H. S. Markus C. B. Bunker K. Kouris D. C. Costa M. J. Harrison 《Journal of neurology》1992,239(7):363-366
Summary Conventional imaging with computed tomography (CT) and magnetic resonance imaging (MRI) may show abnormalities in central nervous system Behcet's syndrome but is normal in some cases. Recently in two cases positron emission tomography has shown abnormalities in blood flow and glucose metabolism far more extensive than the abnormalities seen on CT and MRI scans in the same patients. We report a patient with neuro-Behcet's syndrome presenting with headache and personality change in whom CT and MRI brain imaging was normal, but regional cerebral blood flow imaging using single photon emission tomography with the tracer HMPAO showed extensive perfusion deficits which partially reversed after 3 months of prednisolone therapy. This technique may aid the diagnosis of cerebral involvement in Behcet's syndrome, although the cause and incidence of the perfusion deficits need further evaluation. 相似文献
37.
Geraldo F. Busatto Lyn S. Pilowsky Durval C. Costa John Mertehs Dirk Terriere Peter J. Ell Rachel Mulligan Michael J. Travis Josée E. Leysen Dominic Lui Sveto Gacinovic Wendy Waddington Anne Lingford-Hughes Robert W. Kerwin 《European journal of nuclear medicine and molecular imaging》1997,24(2):119-124
The mapping of 5-HT2 receptors in the brain using functional imaging techniques has been limited by a relative lack of selective radioligands.
Iodine-123 labelled 4-amino-N-[1-[3-(4-fluorophenoxy)propyl]-4-methyl-4-piperidinyl]-5-iodo-2-methoxybenzamide (123I-5-I-R91150 or123I-R93274) is a new ligand for single-photon emission tomography (SPET), with high affinity and selectivity for 5-HT2A receptors. This study reports on preliminary123I-5-I-R91150 SPET, wholebody and blood distribution findings in five healthy human volunteers. Maximal brain uptake was approximately
2% of total body counts at 180 min post injection (p.i.). Dynamic SPET sequences were acquired with the brain-dedicated, single-slice
multi-detector system SEM-810 over 200 min p.i. Early peak uptake (at 5 min p.i.) was seen in the cerebellum, a region free
from 5HT2A receptors. In contrast, radioligand binding in the frontal cortex increased steadily over time, up to a peak at approximately
100–120 min p.i. Frontal cortex-cerebellum activity ratios reached values of 1.4, and remained stable from approximately 100
min p.i. onwards. Multi-slice SPET sequences showed a pattern of regional variation of binding compatible with the autoradiographic
data on the distribution of 5-HT2A receptors in (cerebral cortex>striatum>cerebellum). These findings suggest that123I-5-I-R91150 may be used for the imaging of 5-HT2A receptors in the living human brain with SPET. 相似文献
38.
Ana Sánchez-Romero Israel Oliver David Costa Albina Orduña Javier Lacueva Francisco Pérez-Vicente Antonio Arroyo Rafael Calpena 《Clinical & translational oncology》2006,8(4):294-295
Lung cancer is the most prevalent malignancy in western countries and most of the patients present at advanced stages, but
single splenic metastasis is exceptional instead. We report on a case of a seventy-three-year old male presenting with non-hemoptoic
productive cough, constitutional syndrome and pain in the left lower quadrant. Physical examination and complementary radiological
and hystologycal procedures revealed the presence of an adenocarcinoma of the left lung with probable splenic metastasis.
The patient underwent splenectomy, which confirmed the diagnose of splenic metastasis of lung adenocarcinoma and, secondly,
lung resection was performed. Topics about lung cancer metastasis are discussed. 相似文献
39.
F. V. Costa C. Borghi A. Mussi E. Ambrosioni 《European journal of clinical pharmacology》1986,30(2):145-150
Summary The long-term efficacy of a new vasodilator, cadralazine (ISF 2469), and chlorthalidone have been compared in 20 hypertensive patients not adequately controlled by atenolol. After 4 weeks of treatment with atenolol 100 mg once daily, patients whose diastolic blood pressure was >95 mmHg were randomly divided into two groups to receive in addition to atenolol, either cadralazine 15 mg once daily or chlorthalidone 25 mg once daily. Both treatments were administered for 6 months. At the end of treatment with atenolol and after 3 and 6 months of combination therapy, blood pressure and heart rate were measured at rest and during bicycle exercise 24 h after the last dose. Compared to atenolol alone, both cadralazine and chlorthalidone caused a significant and similar reduction in resting blood pressure. Both groups showed an increase in diastolic blood pressure during exercise while receiving atenolol alone. The addition of chlorthalidone did not modify the pressor response to exercise, whereas patients taking cadralazine had a decrease in exercise diastolic blood pressure, which was fully evident after 6 months of therapy. The reduction in exercise diastolic blood pressure induced by cadralazine was proportional to the increase in exercise heart rate, suggesting a fall in peripheral vascular resistance. Chlorthalidone caused a significant increase in serum glucose and uric acid and a decrease in K+, whereas no change was observed during cadralazine It is concluded that cadralazine given once a day with atenolol has the same efficacy in controlling blood pressure at rest as the combination of atenolol and chlorthalidone, and in addition it improves the pressor response to dynamic exercise and does not cause unwanted metabolic effects. 相似文献
40.