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101.
Seung Min Lee Seung Kyung Hann Soo II Chun Seung Hung Lee Yoon-Kee Park 《The Journal of dermatology》1994,21(2):106-110
A 25-year-old female has had brown to erythematous telangiectatic patches and grouped papules on her face, neck, arm, and trunk since childhood following B.C.G. vaccination. Histopathologically, the lesions consisted of hyperkeratosis, slight acanthosis, tuberculoid granulomas with some Langerhans type giant cells in the mid-dermis. Although various forms of cutaneous tuberculosis after B.C.G. vaccination have been reported, it was difficult for us to assign the patient's skin lesion to any specific disease entity. Remission of her cutaneous lesions occurred clinically and histopathologically after treatment with isoniazid and rifampin. 相似文献
102.
5名电离辐射事故患者外周血T细胞T细胞抗原受体、T细胞分化抗原决定簇-3效应的研究 总被引:1,自引:0,他引:1
文中报道了5名事故性急性骨髓型放射病患者照后2.5和3.5年外周血T淋巴细胞T细胞受体(TCR)基因,TCR、T细胞分化抗原决定簇-3(CD_3)表达与TCR/CD_3复合物功能的辐射效应.发现5名患者于照后2.5年,2名(5.2Gy和2.4Gy,55岁)于照后3.5年外周血T细胞应答抗CD3单抗刺激而增殖的能力尚未完全恢复;经同时用IL-2和抗CD_3单抗刺激,增殖能力比单用抗CD_3单抗刺激有所增强;后2名的外周血TCR、CD_3阳性细胞百分率一直低于正常对照和其他患者;并见一患者出现DNA重排杂交带型.本文并从TCR/CD_3在介导T细胞抗原刺激反应中的作用,电离辐射对TCR/CD_3复合物的影响,后果和意义等方面进行了讨论. 相似文献
103.
104.
利用一只电阻对 Coulter STKS全自动血细胞计数仪故障行应急处理,取得了良好的经济效益.同时,不断总结经验有利于快速、准确地排除故障. 相似文献
105.
人骨形态发生蛋白-2基因转染脂肪源性间充质干细胞的成骨研究 总被引:1,自引:0,他引:1
目的 探讨人骨形态发生蛋白-2(hBMP-2)基因修饰的人脂肪源性间充质干细胞(ADSCs)的成骨能力及基因转染对ADSCs成骨分化的生物学调控。方法 流式细胞技术鉴定从人脂肪组织中提取的细胞为间充质来源的干细胞。将ADSCs转染hBMP+2基因,免疫沉淀+Western blotting法和酶联免疫吸附试验(ELISA)检测hBMP-2表达,确定hBMP-2表达量及表达稳定性,碱性磷酸酶(ALP)染色、ALP定量测定、钙结节染色及RT—PCR分析hBMP-2基因转染对ADSCs向成骨细胞转化的调控,并将转基因细胞注入裸鼠股部肌内,通过X线及组织学检查观察体内成骨情况。结果 流式细胞术证实从脂肪中提取的细胞为间充质来源的干细胞。转基因后免疫沉淀+Western blotting法和ELISA法显示转染hBMP-2的ADSCs具有较高且稳定的hBMP-2的表达,转染21d后表达量无明显降低。ALP染色、ALP定量测定、钙结节染色及RT—PCR发现转基因ADSCs向成骨细胞方向发生分化。裸鼠肌内注射转基因细胞后2周即显示有异位骨形成,4周明显增多,对照组无骨组织形成。结论 转染hBMP-2基因的ADSCs在持续稳定高表达目的蛋白的同时,自身向成骨细胞发生分化,并在裸鼠体内形成异位骨。因此,ADSCs有望作为新的基因工程种子细胞。 相似文献
106.
目的 探讨血管生成活性在子宫内膜癌发展中的价值。方法 采用Ⅷ因子相关抗原为标志物 ,以免疫组化技术对正常子宫内膜、不典型增生内膜 ,子宫内膜癌组织进行微血管密度 (MVD)测定。结果 ①正常组与内膜癌组比较 (P <0 .0 1) ,正常组与不典型增生组比较 (P <0 .0 5 ) ;从正常内膜、不典型增生到内膜癌组织内MVD逐渐增多 (P <0 .0 5 )。②内膜癌组织内MVD与肿瘤细胞分化程度有关 (P <0 .0 5 )。结论 临床采用MVD测定对子宫内膜增生病变发展和追随检查具有重要价值 ,同时MVD测定可作为判断子宫内膜癌预后的指标之一。 相似文献
107.
介绍了大型医疗设备成本效益分析应用系统挂接HIS(“军字一号”)上的设计、功能实现及应用。该应用系统部分实现了大型医用设备的现代经济管理。 相似文献
108.
H C Chung H Y Lim E H Koh J H Kim J K Roh I S Park J S Min K S Lee J K Youn B S Kim 《Yonsei medical journal》1992,33(2):143-152
Recently, metastasis to N3 lymph nodes group was regarded as distant metastasis by the new TNM staging system due to poor overall survival. However, the 5-year overall survival rate of patients with metastasis to N3 groups was 34.5% after curative surgery. Moreover, in patients with metastasis to lymph node subgroups of #12, #13, #14, the overall 5-year survival rate increased upto 47.2% after curative resection and adjuvant chemotherapy. This was similar to that of the patients with metastasis to N1 and N2 lymph nodes groups. But in these highly tumor burden states, no survival benefit was found with the addition of immunotherapy to chemotherapy as we achieved in stage II and III. Therefore, we suggest that, at least, metastasis to #12, #13, #14 lymph nodes subgroups should not be categorized as a distant metastasis. And in these situations, active curative radical surgery with extended lymphadenectomy and adjuvant chemotherapy are recommended. 相似文献
109.
Objective To evaluate the bioequivalence between recombinant human growth hormone (rhGH) for reconstitution, and two dosages of liquid formulation of rhGH [ (151U) 5mg or (301U) lOmg per 3ml ]. Methods The study drugs were tested in a randomized, single-blind and three-period crossover studies in 24 healthy male subjects. The three drugs were administered by subcutaneous injection at a dose of O. 21U/kg body weight. A continuous somatostatin infusion was given in order to suppress the secretion of endogenous GH. The ve- nous blood samples were drawn at different time points to test the serum concentration of GH. The pharmacokinetic parameters were analyzed by statistical methods. Results 90% confidence intervals (CI) of AUC0-24h among three products were all within 80% - 125% interval ( 103. 4% - 116. 5%, 105. 7% - 119. 6% and 91.9% - 103. 7%, respectively), and the Cls of C,~ among three products were all within 70% - 143% interval (91.9% - 114. 0%, 103. 7% -127. 2% and 81.6% -97. 4%, respectively). There was no statisitical difference of tmax among all the three products. Conclusion These data demonstrate that there is bioequivalence between rhGH for reconstitution and two liquid formulations of rhGH. 相似文献
110.
Hyun Chul Kim Sang Woo Nam Yong Keun Cho Hey Jin Jeong Se In Kim Seong Hun Kim Chul Min An In Hee Kim Sang Wook Kim Seung Ok Lee Soo Teik Lee 《Taehan Sohwagi Hakhoe chi》2006,47(3):233-237
Although adenocarcinoma is a well known complication of chronic inflammatory bowel disease, primary gastrointestinal lymphoma occurring in Crohn's disease is rare. A 40-year-old man with 10 year-history of Crohn's disease had multiple longitudinal ulcerative lesions on descending colon in follow-up colonoscopic examination. Microscopic examination of proximal descending colon revealed peripheral T cell lymphoma and other site of the descending colon was consistent with Crohn's disease. The patient reached complete remission of malignant lymphoma after three cycles of combined chemotherapy. He has been well for 10 months with sulfasalazine maintenance therapy but was admitted to the hospital due to spontaneous bowel perforation of ascending colon. Right hemicolectomy was done, but the patient died of post-surgical recurrent mesenteric abscess and sepsis. To the best of our knowledge, this is the first case of Non-Hodgkin's lymphoma complicating Crohn's disease in Korea which was confirmed by immunohistochemical studies. 相似文献