全文获取类型
收费全文 | 24446篇 |
免费 | 1411篇 |
国内免费 | 135篇 |
专业分类
耳鼻咽喉 | 249篇 |
儿科学 | 625篇 |
妇产科学 | 502篇 |
基础医学 | 3672篇 |
口腔科学 | 1043篇 |
临床医学 | 2193篇 |
内科学 | 5661篇 |
皮肤病学 | 669篇 |
神经病学 | 2157篇 |
特种医学 | 562篇 |
外科学 | 2203篇 |
综合类 | 50篇 |
一般理论 | 10篇 |
预防医学 | 2333篇 |
眼科学 | 477篇 |
药学 | 1645篇 |
中国医学 | 112篇 |
肿瘤学 | 1829篇 |
出版年
2024年 | 33篇 |
2023年 | 255篇 |
2022年 | 602篇 |
2021年 | 1024篇 |
2020年 | 613篇 |
2019年 | 818篇 |
2018年 | 929篇 |
2017年 | 643篇 |
2016年 | 769篇 |
2015年 | 837篇 |
2014年 | 1109篇 |
2013年 | 1403篇 |
2012年 | 2193篇 |
2011年 | 2289篇 |
2010年 | 1199篇 |
2009年 | 989篇 |
2008年 | 1687篇 |
2007年 | 1627篇 |
2006年 | 1480篇 |
2005年 | 1369篇 |
2004年 | 1189篇 |
2003年 | 1003篇 |
2002年 | 882篇 |
2001年 | 96篇 |
2000年 | 66篇 |
1999年 | 88篇 |
1998年 | 125篇 |
1997年 | 106篇 |
1996年 | 86篇 |
1995年 | 67篇 |
1994年 | 57篇 |
1993年 | 57篇 |
1992年 | 40篇 |
1991年 | 35篇 |
1990年 | 28篇 |
1989年 | 30篇 |
1988年 | 22篇 |
1987年 | 12篇 |
1986年 | 22篇 |
1985年 | 17篇 |
1984年 | 26篇 |
1983年 | 14篇 |
1982年 | 16篇 |
1981年 | 10篇 |
1980年 | 3篇 |
1979年 | 6篇 |
1978年 | 5篇 |
1977年 | 5篇 |
1975年 | 2篇 |
1974年 | 2篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
111.
Cristina Dopazo Itxarone Bilbao Sonia García Concepcin GmezGavara Mireia Caralt Isabel CamposVarela Lluis Castells Ernest Hidalgo Francisco Moreso Bruno Montoro Ramn Charco 《CTS Clinical and Translational Science》2022,15(6):1544
Tacrolimus (TAC) is a dose‐dependent immunosuppressor with considerable intrapatient variability (IPV) in its pharmacokinetics. The aim of this work is to ascertain the association between TAC IPV at 6 months after liver transplantation (LT) and patient outcome. This single‐center cohort study retrospectively analyzed adult patients who underwent transplantation from 2015 to 2019 who survived the first 6 months with a functioning graft. The primary end point was the patient’s probability of death and the secondary outcome was the loss of renal function between month 6 and the last follow‐up. TAC IPV was estimated by calculating the coefficient of variation (CV) of the dose‐corrected concentration (C0/D) between the third and sixth months post‐LT. Of the 140 patients who underwent LT included in the study, the low‐variability group (C0/D CV < 27%) comprised 105 patients and the high‐variability group (C0/D CV ≥ 27%) 35 patients. One‐, 3‐, and 5‐year patient survival rates were 100%, 82%, and 72% in the high‐variability group versus 100%, 97%, and 93% in the low‐variability group, respectively (p = 0.005). Moreover, significant impaired renal function was observed in the high‐variability group at 1 year (69 ± 16 ml/min/1.73 m2 vs. 78 ± 16 ml/min/1.73 m2, p = 0.004) and at 2 years post‐LT (69 ± 17 ml/min/1.73 m2 vs. 77 ± 15 ml/min/1.73 m2, p = 0.03). High C0/D CV 3–6 months remained independently associated with worse survival (hazard ratio = 3.57, 95% CI = 1.32–9.67, p = 0.012) and loss of renal function (odds ratio = 3.47, 95% CI = 1.30–9.20, p = 0.01). Therefore, high IPV between the third and sixth months appears to be an early and independent predictor of patients with poorer liver transplant outcomes.
Abbreviations
- BPAR
- Biopsy proven acute rejection
- BMI
- Body mass index
- CKD‐EPI
- chronic kidney disease epidemiology collaboration
- CV
- coefficient of variation
- C0/D
- dose‐corrected concentration
- CMV
- cytomegalovirus
- eGFR
- estimated glomerular filtration rate
- HR
- hazard ratio
- HCC
- hepatocellular carcinoma
- ICU
- intensive care unit
- IPV
- intrapatient variability
- i.v.
- intravenously
- LC–MS/MS
- liquid chromatography‐ tandem mass spectrometry
- LT
- liver transplantation
- MELD
- model for end‐stage liver disease
- MMF
- mycophenolate mofetil
- NASH
- Non‐Alcoholic Steatohepatitis
- OR
- odds ratio
- PCR
- polymerase chain reaction
- SD
- Standard Deviation
- TAC
- tacrolimus
- 3–6 M
- three–six months
- WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC?
- WHAT QUESTION DID THIS STUDY ADDRESS?
- WHAT DOES THIS STUDY ADD TO OUR KNOWLEDGE?
- HOW MIGHT THIS CHANGE CLINICAL PHARMACOLOGY OR TRANSLATIONAL SCIENCE?
112.
113.
Chiara Delli Poggi Maria Fusaro Maria Cristina Mereu Maria Luisa Brandi Luisella Cianferotti 《Nutrients》2022,14(12)
Both osteoporosis with related fragility fractures and cardiovascular diseases are rapidly outspreading worldwide. Since they are often coexistent in elderly patients and may be related to possible common pathogenetic mechanisms, the possible reciprocal effects of drugs employed to treat these diseases have to be considered in clinical practice. Bisphosphonates, the agents most largely employed to decrease bone fragility, have been shown to be overall safe with respect to cardiovascular diseases and even capable of reducing cardiovascular morbidity in some settings, as mainly shown by real life studies. No randomized controlled trials with cardiovascular outcomes as primary endpoints are available. While contradictory results have emerged about a possible BSP-mediated reduction of overall mortality, it is undeniable that these drugs can be employed safely in patients with high fracture risk, since no increased mortality has ever been demonstrated. Although partial reassurance has emerged from meta-analysis assessing the risk of cardiac arrhythmias during bisphosphonates treatment, caution is warranted in administering this class of drugs to patients at risk for atrial fibrillation, possibly preferring other antiresorptives or anabolics, according to osteoporosis guidelines. This paper focuses on the complex relationship between bisphosphonates use and cardiovascular disease and possible co-management issues. 相似文献
114.
115.
Ivn Martínez-Baz Itziar Casado Ana Miqueleiz Ana Navascus Francisco Pozo Camino Trobajo-Sanmartín Esther Albniz Fernando Elía Cristina Burgui Miguel Fernndez-Huerta Carmen Ezpeleta Jesús Castilla 《Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin》2022,27(26)
Compared with individuals unvaccinated in the current and three previous influenza seasons, in 2021/22, influenza vaccine effectiveness at primary care level was 37% (95% CI: 16 to 52) for current season vaccination, regardless of previous doses, and 35% (95% CI: −3 to 45) for only previous seasons vaccination. Against influenza A(H3N2), estimates were 39% (95% CI: 16 to 55) and 24% (95% CI: −8 to 47) suggesting moderate effectiveness of current season vaccination and possible remaining effect of prior vaccinations. 相似文献
116.
Mihaela Cristina Buha Laura Ioana Gavrila Rare Candrea Adrian Ctinean Andrei Mocan Doina Miere Alexandru Ttaru 《Nutrients》2022,14(14)
Psoriasis is a chronic inflammatory skin disease with autoimmune pathogenic characteristics and is caused by chronic inflammation, which results in uncontrolled keratinocyte growth and defective differentiation. The link between the gut microbiota and immune system regulation opened a novel angle to understand the pathogenesis of many chronic multifactorial diseases, including psoriasis. Current evidence suggests that modulation of the gut microbiota, both through dietary approaches and through supplementation with probiotics and prebiotics, could represent a novel therapeutic approach. The present work aims to highlight the latest scientific evidence regarding the microbiome alterations of psoriatic patients, as well as state of the art insights in terms of microbiome-targeted therapies as promising preventive and therapeutic tools for psoriasis. 相似文献
117.
Patt JT Spang JE Buck A Cristina H Arras M Schubiger PA Westera G 《Nuclear medicine and biology》2001,28(6):645-655
The carbon-11 labeled enantiomers of nicotinic acetylcholine receptor (nAChR) ligand N-[11C]methyl-homoepibatidine have been synthesized to study the neuronal nicotinic acetylcholine receptors (nAChRs).In vivo evaluations were performed in mice and pig using positron emission tomography (PET). The radioligands displayed a strong enantioselectivity. The (-)-enantiomer showed high uptake in the brain while the (+)-enantiomer was rapidly washed out. In metabolite studies in mice >65% unchanged ligand was found in the blood after 60 minutes. No metabolites were found in the brain. After intravenous application of N-[11C]methyl-(-)-homoepibatidine in the pig specific accumulation in the thalamus was seen. Blocking experiments with cytisine showed specific binding consistent with labeling of the alpha4beta2-nAChR-subtype in the brain. Quantitative kinetic modeling of radiotracers in the pig brain was performed using the arterial input function. The brain uptake of the (-)-isomer was best fitted by a three-compartment model. High distribution volumes were found in the thalamus (DV(TOT) = 66.617, DV(S) = 59.910) versus a low uptake in the cerebellum (DV(TOT) = 8.605m, DV(S) = 1.898). The binding characteristics suggest N-[11C]methyl-(-)-homoepibatidine to be suited for PET imaging studies, but high toxicity prevents routine use in humans. 相似文献
118.
119.
Measuring ammonia from the environmental air is a sensitive and prioritized issue due to its harmful effects on humans, ecosystems, and climate. Ammonia is an environmental pollutant that has an important role in forming secondary inorganic aerosols, the main component of fine particulate matter concentrations in the urban atmosphere. Through this study, we present a gas analyzer that utilizes the technique of laser photoacoustic spectroscopy to measure ammonia concentration in three different sites located in Magurele, (44°20′58″ N 26°01′47″ E, 93 m altitude), Romania, from March to August 2021 at the breathing level of 1.5 m above ground. The ammonia concentrations from the ambient air were elevated in summer (mean of 46.03 ± 8.05 ppb (parts per billion)) compared to those measured in spring (18.62 ± 2.92 ppb), which means that atmospheric temperature affects ammonia concentrations. The highest mean ammonia concentrations occurred in August, with an ammonia concentration level of 100.68 ± 11.12 ppb, and the low mean ammonia concentrations occurred in March, with an ammonia level concentration of 0.161 ± 0.03 ppb. The results confirm that meteorological characteristics (i.e., temperature) and motor vehicles are major contributors to the elevated ammonia levels during the monitoring period. 相似文献
120.