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Bronchial stenosis is a complication of lung transplantation that often requires repeated balloon dilation, endobronchial treatments, and possibly stent placement. Endobronchial stents, particularly uncovered ones, may have several complications including excessive granulation tissue that cause airways obstruction and impaired mucociliary clearance, which may lead to inflammation and infections. Removal of epithelized endobronchial stents is usually done in the operating room using rigid bronchoscopy. Argon plasma coagulation (APC) has been used for removal of biliary stents. One case report described an endotracheal uncovered stent removal using this technique. APC can be used via flexible bronchoscopy, which may carry less risk of complications and can be done in an outpatient setting. In this case, we report using APC, at a low energy level, for complete removal of a totally epithelialized endobronchial uncovered stent in a patient experiencing stent‐related complications. 相似文献
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Introduction: Biology of aging is focused on elucidating the biochemical and genetic pathways that contribute to cellular damage accumulation over time. Thirty years of research are beginning to bear fruit as the first pharmacological interventions based on biology of aging go through clinical trials. Evolutionary theories of aging suggest that naturally selected traits believed to impart fitness in young organisms may be damaging in later life. Three major areas of focus in biology of aging are lifespan, healthspan, and rejuvenation.
Areas covered: Aging research has produced several validated pharmacological interventions currently in clinical trials. Herein, the authors consider two representative case studies: 1) rapamycin analogs and their effect on the mTORC1 pathway, and 2) small molecules that target and kill senescent cells. The authors also provide their expert current and future perspectives on aging targeting drug discovery.
Expert opinion: Aging-related therapeutic interventions will continue to emerge at an accelerating pace, both from research in biology of aging, as well as from coordinated biomedical research in aging-related chronic conditions. 相似文献
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Saskia B. Wortmann Hanka Venselaar Liesbeth T. Wintjes Robert Kopajtich René G. Feichtinger Carla Onnekink Mareike Mühlmeister Ulrich Brandt Jan A. Smeitink Joris A. Veltman Wolfgang Sperl Dirk Lefeber Ger Pruijn Vesna Stojanovic Peter Freisinger Francjan v Spronsen Terry GJ Derks Hermine E. Veenstra‐Knol Johannes A Mayr Agnes Rötig Mark Tarnopolsky Richard J. Rodenburg 《Human mutation》2017,38(12):1786-1795
Mitochondrial protein synthesis involves an intricate interplay between mitochondrial DNA encoded RNAs and nuclear DNA encoded proteins, such as ribosomal proteins and aminoacyl‐tRNA synthases. Eukaryotic cells contain 17 mitochondria‐specific aminoacyl‐tRNA synthases. WARS2 encodes mitochondrial tryptophanyl‐tRNA synthase (mtTrpRS), a homodimeric class Ic enzyme (mitochondrial tryptophan‐tRNA ligase; EC 6.1.1.2). Here, we report six individuals from five families presenting with either severe neonatal onset lactic acidosis, encephalomyopathy and early death or a later onset, more attenuated course of disease with predominating intellectual disability. Respiratory chain enzymes were usually normal in muscle and fibroblasts, while a severe combined respiratory chain deficiency was found in the liver of a severely affected individual. Exome sequencing revealed rare biallelic variants in WARS2 in all affected individuals. An increase of uncharged mitochondrial tRNATrp and a decrease of mtTrpRS protein content were found in fibroblasts of affected individuals. We hereby define the clinical, neuroradiological, and metabolic phenotype of WARS2 defects. This confidently implicates that mutations in WARS2 cause mitochondrial disease with a broad spectrum of clinical presentation. 相似文献