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101.
102.
DG Ranatunga MG Richardson DM Brooks 《Journal of Medical Imaging and Radiation Oncology》2007,51(2):182-185
Knotting of intravascular catheters is an uncommon but a well‐recognized occurrence. The Swan–Ganz catheter (SGC) is the one that knots most commonly. A case of a knotted SGC is described in a patient with a persistent left‐sided superior vena cava, and we propose that the presence of a left‐sided superior vena cava is a risk factor for knot formation not previously reported. We review the published work on the risk factors for knot formation and on the techniques used to remove knotted SGC. We describe a technique using a gooseneck snare and Omni Flush catheter (Angiodynamics, Queensbury, NY, USA) to loosen and untie a knotted SGC. 相似文献
103.
Emma Dawson DBO Mandeep S. Sagoo MB PhD MRCOphth Jodhbir S. Mehta FRCS FRCOphth Richard Comer MD FRCOphth John Hungerford FRCS FRCOphth John Lee DM FRCS FRCP FRCOphth 《Journal of AAPOS》2007,11(6):584-588
PURPOSE: To ascertain the incidence of persistent strabismus in patients treated with plaque brachytherapy and its subsequent treatment. METHODS: A single center retrospective case note review of adult patients with persistent diplopia or strabismus following plaque brachytherapy for all types of intraocular tumors between 1996 and 2004. RESULTS: A total of 929 consecutive adults underwent plaque brachytherapy during the study period at a single center. Sixteen patients (1.7%) with treated uveal melanoma developed persistent diplopia or strabismus. In 11 patients (69%) the timing of onset was in the first year, in 2 (13%) in the second year, and one each (6% each) in years 5, 7, and 8. Two patients (13%) did not require any intervention. Fourteen patients (88%) required treatment: 7 (50%) were treated with prisms only, 3 (21%) underwent botulinum toxin (BTXA) injections, and 4 (29%) were treated with extraocular muscle surgery (3 required one operation and one required 2 procedures). CONCLUSIONS: The incidence of ocular motility disorders following plaque brachytherapy in our cohort was 1.7% over 8 years and we include this in the consent process for conservative treatment of intraocular tumors. Options for treatment for persistent diplopia or strabismus include prisms, botulinum toxin injection, or surgery. 相似文献
104.
105.
Cressey TR Tilby MJ Newell DR 《European journal of cancer (Oxford, England : 1990)》2002,38(4):586-593
Telomere stabilisation is a critical step in tumorigenesis and telomerase, an enzyme which counteracts telomeric DNA loss, is active in most tumours. Conflicting evidence has been published concerning the potential use of telomerase activity as a measurement of drug-induced tumour cell killing. In this study, the time courses of telomerase loss and induction of apoptosis were investigated in two testicular cell lines, Susa CP and 833 K, following 4-h exposure to cisplatin, melphalan or doxorubicin. Telomerase activity was only affected in both cell lines at 20 h following exposure to high concentrations of cisplatin (100x the drug concentrations causing 50% growth inhibition (IC(50) values)). The time course of melphalan-induced telomerase loss, which was again only apparent at 100x IC(50) concentrations, varied between the cell lines and doxorubicin (100x IC(50)) did not induce telomerase loss in either of the cell lines. Importantly, the levels and rates of appearance of apoptotic cells (nuclear morphology and annexin V staining) were similar for all three drugs in both cell lines; i.e. cisplatin, melphalan and doxorubicin (100x IC(50)) caused similar frequencies of apoptosis in Susa CP cells at 24 h whereas telomerase activities were 65, 123 and 96% of the control, respectively. The possibility that telomerase activity was lost following cisplatin treatment through a direct interaction of cisplatin with telomerase was discounted. Additionally, the relative levels of the RNA component of telomerase (hTR) and mRNA for the telomerase catalytic subunit (hTERT) were not related to the observed decreases in telomerase activity. These data indicate that telomerase activity is not a reliable indicator of chemosensitivity in human testicular cancer cells. Furthermore, cisplatin-induced loss of telomerase activity is not due to a direct reaction with the enzyme or decreased hTR levels. 相似文献
106.
目的:对68例老年高血压患者分别应用氯沙坦/氢氯噻嗪固定复方制荆(商品名:海捷亚默沙东公司)与苯那普利治疗,比较两组患者降压效果、安全性以及血尿酸的变化。方法:对68例原发性高血压患者分为氯沙坦/氢氯噻嗪组(A组)34例和苯那普利(B组)34例。结果:A组34例患者,降压疗效总有效率89.5%,B组需合并使用氢氟噻嗪28/34例,总有效率78.8%。A组不良反应2例,B组不良反应6例。A组治疗后血尿酸平均增加22.3umol/L,B组患者来服用氢氯噻嗪16例,治疗后血尿酸平均增加4.8umol/L,服用苯那普利/氢氯噻嗪的28例患者血尿酸平均增加46.1umol/L。结论:氯沙坦/氢氯噻嗪固定复方制剂对高血压患者具有更好的安全性和耐受性。 相似文献
107.
膦甲酸钠治疗疱疹病毒相关性进展性卒中26例 总被引:1,自引:0,他引:1
1临床资料我院神经内科200112/200203应用膦甲酸钠(PFA,foscarnetsodium)治疗进展性卒中(progressivestroke,PS)患者26例.男12例,女14例,年龄35~70(平均57±14)岁.总病程19~72d.有高血压病史19例,有短暂性脑缺血发作病史11例,有脑梗死病史3例,有冠心病病史1例.标准符合1995年第四届全国脑血管病会议脑梗死诊断标准[1],并经脑CT或MRI证实为脑梗死;发病后1wk内病情逐步或阶梯样加重,临床常规治疗不能阻止病情进展,按1995年第四届全国脑血管病会议神经功能缺损评分标准[2]评分增加2分(包括2分)以上.采用金标免疫斑点法检测患者血清中人巨… 相似文献
108.
Dr. Punita Kumari Sodhi MS DNB B. P. Gulliani MBBS MS K. P. S. Malik MBBS MS Dr. D. C. Jain MD DM 《Annals of Ophthalmology》2005,37(2):117-122
Optic nerve head swelling is caused by either ocular or systemic diseases of inflammatory, infective, infiltrative, compressive,
or ischemic origin. Uncommonly, an isolated optic nerve head swelling without the above underlying mechanisms might also occur.
Two patients presented with unilateral, isolated optic nerve head swelling. A detailed oculoneurological examination and a
series of investigations failed to indicate any pathology. No probable cause for optic nerve head swelling in these patients
was determined by the authors.
the authors have stated that they do not have a significant financial interest or other relationship with any product manufacturer
or privider of services discussed in this article. The authors also do not discuss the use of off-label products, which include
unlabeled, unapproved, or investigative products or devices. 相似文献
109.
110.
MH Galea DM FRCS Professor RW Blamey MD FRCS 《Breast cancer research and treatment》1993,28(3):299-300
on behalf of the Nottingham Breast Unit 相似文献