全文获取类型
收费全文 | 1089篇 |
免费 | 151篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 72篇 |
妇产科学 | 17篇 |
基础医学 | 130篇 |
口腔科学 | 33篇 |
临床医学 | 164篇 |
内科学 | 221篇 |
皮肤病学 | 15篇 |
神经病学 | 157篇 |
特种医学 | 93篇 |
外科学 | 43篇 |
综合类 | 27篇 |
预防医学 | 89篇 |
眼科学 | 16篇 |
药学 | 109篇 |
肿瘤学 | 45篇 |
出版年
2023年 | 13篇 |
2022年 | 4篇 |
2021年 | 15篇 |
2020年 | 13篇 |
2019年 | 10篇 |
2018年 | 27篇 |
2017年 | 20篇 |
2016年 | 22篇 |
2015年 | 21篇 |
2014年 | 29篇 |
2013年 | 34篇 |
2012年 | 37篇 |
2011年 | 38篇 |
2010年 | 40篇 |
2009年 | 51篇 |
2008年 | 44篇 |
2007年 | 34篇 |
2006年 | 27篇 |
2005年 | 43篇 |
2004年 | 28篇 |
2003年 | 35篇 |
2002年 | 31篇 |
2001年 | 30篇 |
2000年 | 25篇 |
1999年 | 36篇 |
1998年 | 36篇 |
1997年 | 46篇 |
1996年 | 47篇 |
1995年 | 35篇 |
1994年 | 28篇 |
1993年 | 24篇 |
1992年 | 20篇 |
1991年 | 18篇 |
1990年 | 16篇 |
1989年 | 27篇 |
1988年 | 28篇 |
1987年 | 16篇 |
1986年 | 25篇 |
1985年 | 26篇 |
1984年 | 26篇 |
1983年 | 15篇 |
1982年 | 21篇 |
1981年 | 10篇 |
1980年 | 16篇 |
1979年 | 10篇 |
1978年 | 8篇 |
1977年 | 6篇 |
1976年 | 7篇 |
1974年 | 4篇 |
1971年 | 4篇 |
排序方式: 共有1243条查询结果,搜索用时 15 毫秒
41.
Robert W. McConkey RANP RNP MSc BSc PG Dip PG Cert Therese Kelly RANP RNP MSc PG Dip PG Cert Rachael Dalton RANP RNT RNP MSc BSc PG Dip Geraldine Rooney cANP RNP BSc PG Dip PG Cert Michelle Healy cANP BSc PG Cert Louise Murphy PhD BSc PG Dip RPN RNT Maura Dowling PhD MSc RGN RNT 《International Journal of Urological Nursing》2023,17(1):78-83
Evidence based practice is essential to advanced practice nursing, enabling the delivery of quality care and improved patient outcomes. As the name suggests, it requires healthcare decisions to be based on the best available and current evidence. Advanced practice nurses need astute critical analysis skills to appraise the evolving literature, and require research skills to lead on scientific inquiry and develop the profession. Yet, advanced practice nurses may not recognize themselves as research leaders. Participation in a journal club can promote evidence-based practice, improve clinician's critical thinking skills, and expose members to different research methodologies, however, nurses continue to face barriers to participation in these clubs. Establishing a clinical-academic partnership appears to be both mutually beneficial for clinicians and academics and is a significant enabler in the sustainability and functioning of the club through sharing expertise and experience. A supportive workplace culture is favourable to research utilization and knowledge translation. This paper outlines the role, practicalities, challenges, and benefits of setting up a hybrid urology journal and research club for advanced practice nurses in a clinical-academic partnership. 相似文献
42.
Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease 下载免费PDF全文
Steiner RA Hohmann JG Holmes A Wrenn CC Cadd G Juréus A Clifton DK Luo M Gutshall M Ma SY Mufson EJ Crawley JN 《Proceedings of the National Academy of Sciences of the United States of America》2001,98(7):4184-4189
Galanin is a neuropeptide with multiple inhibitory actions on neurotransmission and memory. In Alzheimer's disease (AD), increased galanin-containing fibers hyperinnervate cholinergic neurons within the basal forebrain in association with a decline in cognition. We generated transgenic mice (GAL-tg) that overexpress galanin under the control of the dopamine beta-hydroxylase promoter to study the neurochemical and behavioral sequelae of a mouse model of galanin overexpression in AD. Overexpression of galanin was associated with a reduction in the number of identifiable neurons producing acetylcholine in the horizontal limb of the diagonal band. Behavioral phenotyping indicated that GAL-tgs displayed normal general health and sensory and motor abilities; however, GAL-tg mice showed selective performance deficits on the Morris spatial navigational task and the social transmission of food preference olfactory memory test. These results suggest that elevated expression of galanin contributes to the neurochemical and cognitive impairments characteristic of AD. 相似文献
43.
44.
Gratwohl A Brand R Apperley J Crawley C Ruutu T Corradini P Carreras E Devergie A Guglielmi C Kolb HJ Niederwieser D;Chronic Leukemia Working Party of the European Group for Blood Marrow Transplantation 《Haematologica》2006,91(4):513-521
The introduction of imatinib mesylate has changed attitudes towards hematopoietic stem cell transplantation (HSCT) for chronic myeloid leukemia (CML). Information on the current use and results of HSCT is warranted. Data from 592 teams in 42 European countries described their use of HSCT for CML from 1990 to 2004. Outcomes were analyzed for 13,416 patients, with a median age of 36 years (range 1-71 years); 60% were male. The analysis considered three time cohorts, 1980 to 1990, 1991 to 1999 and 2000 to 2003. Survival, transplant-related mortality and relapse incidence were assessed at 20 years for the first cohort and compared at 2 years between the three cohorts. The numbers of HSCT for CML increased from 540 allogeneic HSCT in 1990 to 1,396 HSCT in 1999 and declined to 802 in 2004. One third of all patients and half of those with a low risk were alive at 20 years. Survival at 2 years has improved from 53% to 61% in the most recent years due to a reduction in transplant-related mortality from 41% to 30% in all patients and from 31% to 17% in low-risk patients. Stage, donor type, time interval, age and donor-recipient sex combination remain the main risk factors; patients with a risk score of 0 or 1 have a survival probability of 80% at 2 years. HSCT remains an important treatment option for patients with CML. The data describe the current status of this option and the outcome a patient can expect today. They provide an objective basis for decision making. 相似文献
45.
Ventilator-associated pneumonia (VAP) is a common cause of morbidity, antibiotic use, increased length of stay and, possibly,
increased mortality in ICU patients. Colonization of the oropharyngeal cavity with potentially pathogenic micro-organisms
is instrumental in the pathogenesis of VAP, and selective oropharyngeal decontamination (SOD) with antibiotics (AB-SOD) or
antiseptics, such as chlorhexidine gluconate (CHX-SOD), has been associated with reduced incidences of VAP. In a recent issue
of Critical Care Scannapieco and colleagues investigated differences in oropharyngeal colonization between mechanically ventilated patients
receiving oropharyngeal decontamination with 0.12% CHX-SOD either once or twice daily compared to placebo. CHX-SOD was associated
with a reduction in Staphylococcus aureus colonization, but the study was underpowered to demonstrate a reduction in VAP incidence. We urgently need well-designed
and adequately powered studies to evaluate the potential benefits of CHX-SOD on patient outcome in ICUs. 相似文献
46.
47.
48.
M English S Murphy I Mwangi J Crawley N Peshu K Marsh 《Archives of disease in childhood》1995,72(4):334-336
Respiratory abnormalities are common presentations of malaria and acute respiratory tract infection, both of which are major causes of childhood mortality and morbidity in sub-Saharan Africa. Appropriate management depends on accurate assessment of disease severity which for the majority of children must be based on clinical signs alone. Choosing which signs best serve this purpose remains a considerable problem particularly in malaria endemic areas. As part of a prospective study to define clinical signs indicative of life threatening malaria video recordings were used to examine the level of agreement between clinicians for potentially important respiratory signs in 51 children. Overall agreement was good for recession, severe recession, and nasal flaring (kappa = 0.57, 0.50, and 0.60 respectively) and substantial for deep breathing and the summary impression of respiratory distress (kappa = 0.70 and 0.69 respectively). However, within this substantial variation in interpretation was apparent between individual observers from slight to almost perfect agreement (kappa values 0.10-0.92). Video is a useful tool to demonstrate interobserver variation and it may also allow training in recognition of signs and a means of standardising clinical signs between centres. 相似文献
49.
Reduced aggression in mice lacking the serotonin transporter 总被引:16,自引:4,他引:12
Abstract
Rationale. The possible role of γ-aminobutyric acid (GABA) in human aggression was evaluated by administering baclofen, a GABA-B agonist
and comparing the effects on laboratory measures of aggression and escape among subjects with and without a history of conduct
disorder.
Methods. Twenty male subjects with a history of criminal behavior participated in experimental sessions, which measured aggressive
and escape responses. Ten subjects had a history of childhood conduct disorder (CD+) and ten control subjects had no history
of CD. Aggression was measured using the point subtraction aggression paradigm (PSAP), which provides subjects with aggressive,
escape, and monetary-reinforced response options.
Results. Acute doses (0.07, 0.14 and 0.28 mg/kg) of baclofen had remarkably different effects on aggressive responses among CD+ subjects
relative to control subjects. Aggressive responses of CD+ subjects decreased, while aggressive responses of control subjects
increased following baclofen administration. Baclofen decreased escape responses for both CD+ and control subjects. No changes
in monetary-reinforced responses were observed, indicative of no central nervous system stimulation or sedation.
Conclusions. The GABA-B agonist baclofen suppressed aggressive responses in subjects with a history of childhood CD, while producing the
opposite effect in control subjects. These suggest a possible unique role for GABA in the regulation of aggression in CD+
population.
Electronic Publication 相似文献
50.