全文获取类型
收费全文 | 1575篇 |
免费 | 143篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 40篇 |
妇产科学 | 22篇 |
基础医学 | 215篇 |
口腔科学 | 32篇 |
临床医学 | 231篇 |
内科学 | 273篇 |
皮肤病学 | 17篇 |
神经病学 | 155篇 |
特种医学 | 19篇 |
外科学 | 115篇 |
综合类 | 24篇 |
一般理论 | 1篇 |
预防医学 | 216篇 |
眼科学 | 14篇 |
药学 | 108篇 |
中国医学 | 11篇 |
肿瘤学 | 207篇 |
出版年
2024年 | 3篇 |
2023年 | 30篇 |
2022年 | 31篇 |
2021年 | 90篇 |
2020年 | 60篇 |
2019年 | 71篇 |
2018年 | 91篇 |
2017年 | 51篇 |
2016年 | 70篇 |
2015年 | 63篇 |
2014年 | 70篇 |
2013年 | 76篇 |
2012年 | 111篇 |
2011年 | 113篇 |
2010年 | 58篇 |
2009年 | 55篇 |
2008年 | 94篇 |
2007年 | 95篇 |
2006年 | 85篇 |
2005年 | 83篇 |
2004年 | 76篇 |
2003年 | 70篇 |
2002年 | 68篇 |
2001年 | 2篇 |
2000年 | 7篇 |
1999年 | 9篇 |
1998年 | 11篇 |
1997年 | 7篇 |
1996年 | 4篇 |
1995年 | 4篇 |
1994年 | 3篇 |
1993年 | 2篇 |
1992年 | 4篇 |
1986年 | 5篇 |
1985年 | 4篇 |
1984年 | 2篇 |
1976年 | 2篇 |
1973年 | 2篇 |
1972年 | 6篇 |
1970年 | 2篇 |
1967年 | 4篇 |
1964年 | 3篇 |
1963年 | 2篇 |
1962年 | 3篇 |
1961年 | 1篇 |
1960年 | 1篇 |
1959年 | 1篇 |
1958年 | 1篇 |
1931年 | 1篇 |
1929年 | 1篇 |
排序方式: 共有1719条查询结果,搜索用时 31 毫秒
41.
42.
43.
Mia Fujisawa Masashi Matsushima Joaquim Carreras Kenichi Hirabayashi Yara Y. Kikuti Takashi Ueda Motoki Kaneko Ryutaro Fujimoto Masaya Sano Erika Teramura Makiko Monma Hirohiko Nakae Takayoshi Suzuki Hidekazu Suzuki Naoya Nakamura 《Pathology international》2021,71(12):823-830
Intracholecystic papillary neoplasms are newly defined precancerous lesions. According to Classification of the World Health Organization, they have four histological morphologies, which are biliary, gastric, intestinal, and oncocytic. This study evaluated 17 patients with resected intracholecystic papillary neoplasms in terms of histological, immunohistochemical, and copy number variation (CNV). The histological subtypes included 5 cases of low-grade (5 gastric) and 12 cases of high-grade (6 gastric and 6 biliary) neoplasms. Most cases showed high expression of MUC1, MUC5AC, and CK7, moderate expression of MUC6 and Ki-67, and low expression of CK20, MUC2, and CDX2. The CNV profile identified gain of 7q in 12%, and loss of 1p (18%), 5q (29%), 9p (35%), 12p (17%), 17p (24%), and 19p (18%). No CNVs were observed in low-grade neoplasms, whereas high-grade ones had increasing abnormalities. β-catenin was often expressed in the nucleus of neoplasms with gastric morphology, suggesting the involvement of the Wnt/β-catenin pathway. However, it was not expressed among those with biliary morphology, which instead exhibited high p53 expression. Neoplasms with biliary morphology showed more CNV changes (9p, 17p, 19p losses). Distinct immunological and CNV patterns were seen in both morphologies, suggesting differences in their pathogenesis. More CNVs accumulated with tumor progression. 相似文献
44.
Social inequality in adverse birth outcomes has been demonstrated in several countries. The present study examined the separate and joint effects of parental education and work in order to investigate the causal pathways of social class effects on adverse birth outcomes in Korea. The occurrence of low birth weight, preterm births, and intrauterine growth retardation was examined among 7,766,065 births in Korea from 1995 to 2008. The effect of social inequality, as represented by parental education and work, was examined against adverse birth outcomes using multivariate logistic regression after controlling for other covariates. Parental education had the most significant and greatest effect on all three adverse outcomes, followed by parental work and employment, which had lesser effects. For adverse birth outcomes, the gap between educational levels increased steadily in Korea from 1995 to 2008. Throughout the analysis, the effect of maternal manual work on adverse birth outcomes was apparent in the study results. Given this evidence of social inequality in education and employment, social interventions should aim at more in-depth and distal determinants of health. 相似文献
45.
Joan L Robinson Jane C Finlay Mia Eileen Lang Robert Bortolussi Canadian Paediatric Society Community Paediatrics Committee Infectious Diseases Immunization Committee 《Paediatrics & child health》2015,20(1):45-47
Prophylactic antibiotics for urinary tract infections are no longer routinely recommended. A large number of children must be given prophylaxis to prevent one infection and antibiotic resistance is a major concern when treating community-acquired urinary tract infections. The results of three recent significant studies are examined, with focus on the efficacy of prophylaxis, and recommendations are made. 相似文献
46.
Mia Dunkley Yael Gelfer Debbie Jackson Evette Parnell Jennifer Armstong Cristina Rafter Deborah M. Eastwood 《Journal of children's orthopaedics》2015,9(3):183-189
BackgroundThe Ponseti method is the preferred treatment for idiopathic clubfoot. Although popularised by orthopaedic surgeons it has expanded to physiotherapists and other health practitioners. This study reviews the results of a physiotherapist-led Ponseti service for idiopathic and non-idiopathic clubfeet and compares these results with those reported by other groups.MethodA prospective cohort of clubfeet (2005–2012) with a minimum 2-year follow-up after correction was reviewed. Physiotherapists treated 91 children—41 patients (69 feet) had non-idiopathic deformities and 50 children (77 feet) were idiopathic. Objective outcomes were evaluated and compared to results from other groups managing similar patient cohorts.ResultsThe mean follow-up was 4.6 years (range 2–8.3 years) for both groups. The non-idiopathic group required a median of 7 casts to correct the clubfoot deformity with an 83 % tenotomy rate compared to a median of 5 casts for the idiopathic group with a 63 % tenotomy rate. Initial correction was achieved in 96 % of non-idiopathic feet and in 100 % of idiopathic feet. Recurrence requiring additional treatment was higher in the non-idiopathic group with 40 % of patients (36 % of feet) sustaining a relapse as opposed to 8 % (6 % feet) in the idiopathic group. Surgery was required in 26 % of relapsed non-idiopathic feet and 6 % of idiopathic.ConclusionsAlthough Ponseti treatment was not as successful in non-idiopathic feet as in idiopathic feet, deformity correction was achieved and maintained in the mid-term for the majority of feet. These results compare favourably to other specialist orthopaedic-based services for Ponseti management of non-idiopathic clubfeet.
Level of evidence
Prognostic Level III. 相似文献47.
48.
49.
Gaudet MM Falk RT Stevens RD Gunter MJ Bain JR Pfeiffer RM Potischman N Lissowska J Peplonska B Brinton LA Garcia-Closas M Newgard CB Sherman ME 《The Journal of clinical endocrinology and metabolism》2012,97(9):3216-3223
Context: Endometrial cancer is associated with metabolic disturbances related to its underlying risk factors, including obesity and diabetes. Identifying metabolite biomarkers associated with endometrial cancer may have value for early detection, risk assessment, and understanding etiology. Objective: The objective of the study was to evaluate the reliable measurement of metabolites in epidemiological studies with nonstandardized blood collection; confirm previously reported correlations of metabolites with body size; and assess differences in metabolite levels between cases and controls. Design: This was the Polish Endometrial Cancer Study (2001-2003). Setting: This study was a population-based case-control study. Patients: Patients included 250 cases and 250 controls. Intervention: The intervention included the measurement of serum metabolite levels of 15 amino acids, 45 acylcarnitines, and nine fatty acids. Main Outcome Measure: The main outcome measure was endometrial cancer. Results: Body mass index was correlated with levels of valine (r = 0.26, P = 3.4 × 10(-5)), octenoylcarnitine (r = 0.24, P = 1.5 × 10(-4)), palmitic acid (r = 0.26, P = 4.4 × 10(-5)), oleic acid (r = 0.28, P = 9.9 × 10(-6)), and stearic acid (r = 0.26, P = 2.9 × 10(-5)) among controls. Only stearic acid was inversely associated with endometrial cancer case status (quartile 4 vs. quartile 1: odds ratio 0.37, 95% confidence interval 0.20-0.69, P for trend = 1.2 × 10(-4)). Levels of the C5-acylcarnitines, octenoylcarnitine, decatrienoylcarnitine, and linoleic acid were significantly lower in cases than controls (odds ratios ranged from 0.21 to 0.38). Conclusions: These data demonstrate that previously reported variations in metabolomic profiles with body mass index can be replicated in population-based studies with nonfasting blood collection protocols. We also provide preliminary evidence that large differences in metabolite levels exist between cases and controls, independent of body habitus. Our findings warrant assessment of metabolic profiles, including the candidate markers identified herein, in prospectively collected blood samples to define biomarkers and etiological factors related to endometrial cancer. 相似文献
50.
Ostrowska Dahlgren B Allen M Lindstr?m AC Bjerke M Blomstr?m-Lundqvist C 《Journal of interventional cardiac electrophysiology》2012,34(1):11-18