全文获取类型
收费全文 | 3086篇 |
免费 | 255篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 65篇 |
儿科学 | 73篇 |
妇产科学 | 88篇 |
基础医学 | 476篇 |
口腔科学 | 199篇 |
临床医学 | 374篇 |
内科学 | 643篇 |
皮肤病学 | 38篇 |
神经病学 | 171篇 |
特种医学 | 176篇 |
外科学 | 568篇 |
综合类 | 34篇 |
预防医学 | 125篇 |
眼科学 | 37篇 |
药学 | 139篇 |
中国医学 | 1篇 |
肿瘤学 | 144篇 |
出版年
2023年 | 16篇 |
2022年 | 22篇 |
2021年 | 44篇 |
2020年 | 34篇 |
2019年 | 50篇 |
2018年 | 55篇 |
2017年 | 57篇 |
2016年 | 71篇 |
2015年 | 71篇 |
2014年 | 100篇 |
2013年 | 129篇 |
2012年 | 199篇 |
2011年 | 228篇 |
2010年 | 144篇 |
2009年 | 125篇 |
2008年 | 216篇 |
2007年 | 206篇 |
2006年 | 179篇 |
2005年 | 201篇 |
2004年 | 156篇 |
2003年 | 147篇 |
2002年 | 140篇 |
2001年 | 60篇 |
2000年 | 51篇 |
1999年 | 43篇 |
1998年 | 36篇 |
1997年 | 20篇 |
1996年 | 12篇 |
1995年 | 15篇 |
1994年 | 24篇 |
1993年 | 20篇 |
1992年 | 42篇 |
1991年 | 37篇 |
1990年 | 31篇 |
1989年 | 23篇 |
1988年 | 21篇 |
1987年 | 37篇 |
1986年 | 21篇 |
1985年 | 34篇 |
1984年 | 19篇 |
1983年 | 20篇 |
1981年 | 11篇 |
1979年 | 17篇 |
1976年 | 11篇 |
1975年 | 13篇 |
1974年 | 10篇 |
1973年 | 11篇 |
1972年 | 15篇 |
1971年 | 16篇 |
1970年 | 14篇 |
排序方式: 共有3351条查询结果,搜索用时 15 毫秒
71.
Physical inactivity in patients with rheumatoid arthritis: data from twenty-one countries in a cross-sectional, international study 总被引:1,自引:0,他引:1
Sokka T Häkkinen A Kautiainen H Maillefert JF Toloza S Mørk Hansen T Calvo-Alen J Oding R Liveborn M Huisman M Alten R Pohl C Cutolo M Immonen K Woolf A Murphy E Sheehy C Quirke E Celik S Yazici Y Tlustochowicz W Kapolka D Skakic V Rojkovich B Müller R Stropuviene S Andersone D Drosos AA Lazovskis J Pincus T;QUEST-RA Group 《Arthritis and rheumatism》2008,59(1):42-50
OBJECTIVE: Regular physical activity is associated with decreased morbidity and mortality. Traditionally, patients with rheumatoid arthritis (RA) have been advised to limit physical exercise. We studied the prevalence of physical activity and associations with demographic and disease-related variables in patients with RA from 21 countries. METHODS: The Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis (QUEST-RA) is a cross-sectional study that includes a self-report questionnaire and clinical assessment of nonselected consecutive outpatients with RA who are receiving usual clinical care. Frequency of physical exercise (>or=30 minutes with at least some shortness of breath, sweating) is queried with 4 response options: >or=3 times weekly, 1-2 times weekly, 1-2 times monthly, and no exercise. RESULTS: Between January 2005 and April 2007, a total of 5,235 patients from 58 sites in 21 countries were enrolled in QUEST-RA: 79% were women, >90% were white, mean age was 57 years, and mean disease duration was 11.6 years. Only 13.8% of all patients reported physical exercise>or=3 times weekly. The majority of the patients were physically inactive with no regular weekly exercise: >80% in 7 countries, 60-80% in 12 countries, and 45% and 29% in 2 countries, respectively. Physical inactivity was associated with female sex, older age, lower education, obesity, comorbidity, low functional capacity, and higher levels of disease activity, pain, and fatigue. CONCLUSION: In many countries, a low proportion of patients with RA exercise. These data may alert rheumatologists to motivate their patients to increase physical activity levels. 相似文献
72.
73.
Margaret L. McKinnon Jacob Rozmus Shan-Yu Fung Aaron F. Hirschfeld Kate L. Del Bel Leah Thomas Nico Marr Spencer D. Martin Ashish K. Marwaha John J. Priatel Rusung Tan Christof Senger Angela Tsang Julie Prendiville Anne K. Junker Michael Seear Kirk R. Schultz Laura M. Sly Robert A. Holt Millan S. Patel Jan M. Friedman Stuart E. Turvey 《The Journal of allergy and clinical immunology》2014
74.
75.
76.
Matthias Watzka Christof Geisen Monika Scheer Regina Wieland Verena Wiegering Thomas Dörner Hans-Jürgen Laws Fatma Gümrük Sahin Hanalioglu Sule Ünal Davut Albayrak Johannes Oldenburg 《Thrombosis research》2014
Functional limitations for the vitamin K cycle, caused either by mutations in gamma-glutamyl carboxylase or vitamin K epoxide reductase genes, result in hereditary deficiency of vitamin K-dependent coagulation factors (VKCFD1 and VKCFD2, respectively). Patients suffering from VKCFD often share several other anatomical irregularities which are not related to haemostasis. Here we report on nine patients, eight of them previously unreported, who presented with VKCFD1. All were examined with special attention to vitamin K-dependent coagulation factors as well as to bone and heart development and to other anatomical signs of embryonal vitamin K deficiency. In total, we detected ten mutations in the gamma-glutamyl carboxylase gene of which seven have not been previously reported. Most interestingly, additional non-bleeding phenotypes were observed in all patients including midfacial hypoplasia, premature osteoporosis, cochlear hearing loss, heart valve defects, pulmonary stenosis, or pseudoxanthoma elasticum-like phenotype. Undercarboxylated matrix Gla protein, osteocalcin, and periostin appear to be responsible for these defects which are also observed in cases of fetal warfarin syndrome. 相似文献
77.
Tobias Geis Klaus Marquard Tanja Rödl Christof Reihle Sophie Schirmer Thekla von Kalle Antje Bornemann Ute Hehr Markus Blankenburg 《Neurogenetics》2013,14(3-4):205-213
Defects in dystroglycan post-translational modification result in congenital muscular dystrophy with or without additional eye and brain involvement, are referred to as secondary dystroglycanopathies and have been associated with mutations in 11 different genes encoding glycosyltransferases or associated proteins. However, only one patient with a mutation in the dystroglycan encoding gene DAG1 itself has been described before. We here report a homozygous novel DAG1 missense mutation c.2006G>T predicted to result in the amino acid substitution p.Cys669Phe in the β-subunit of dystroglycan in two Libyan siblings. The affected girls presented with a severe muscle–eye–brain disease-like phenotype with distinct additional findings of macrocephaly and extended bilateral multicystic white matter disease, overlapping with the cerebral findings in patients with megalencephalic leucoencephalopathy with subcortical cysts. This novel clinical phenotype observed in our patients further expands the clinical spectrum of dystroglycanopathies and suggests a role of DAG1 not only for dystroglycanopathies but also for some forms of more extensive and multicystic leucodystrophy. 相似文献
78.
79.
Britta Auel Hartmut Goldschmidt Thomas Geer Thomas M. Moehler Uwe Platzbecker Ralph Naumann Igor Blau Mathias H?nel Wolfgang Knauf Holger Nückel Hans-Jürgen Salwender Christof Scheid Katja Weisel Marcus Gorschlüter Axel Glasmacher Ingo G. H. Schmidt-Wolf The German Refractory Myeloma Study Group 《Indian journal of hematology & blood transfusion》2012,28(2):67-76
Treatment of relapsed or refractory multiple myeloma remains a challenge and novel treatment regimen are required. Here, a matched pair analysis was performed comparing TCID (thalidomide, cyclophosphamide, idarubicin, dexamethasone) treatment to the treatment of patients with VID (vincristine, idarubicin, dexamethasone) or with VRID (vinorelbine, idarubicin, dexamethasone) for relapsed or refractory multiple myeloma. In total, 197 patients were enrolled in multicenter trials. After matching for important prognostic variables 46 matched-pairs (total of 138 patients) could be analysed with regard to survival, toxicity and efficacy. Interestingly, a significant improvement of overall response rate (ORR) for TCID treatment compared to VID and VRID was found. In addition, TCID treatment also led to a significantly higher overall survival (OS) as well as progression-free survival (PFS) compared to VID and VRID. In conclusion, TCID treatment appears to be superior to VRID and VID treatment in patients with progressive or refractory myeloma. 相似文献
80.