全文获取类型
收费全文 | 821篇 |
免费 | 43篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 21篇 |
妇产科学 | 8篇 |
基础医学 | 109篇 |
口腔科学 | 28篇 |
临床医学 | 106篇 |
内科学 | 242篇 |
皮肤病学 | 2篇 |
神经病学 | 75篇 |
特种医学 | 44篇 |
外科学 | 84篇 |
综合类 | 9篇 |
预防医学 | 55篇 |
眼科学 | 14篇 |
药学 | 24篇 |
肿瘤学 | 40篇 |
出版年
2024年 | 2篇 |
2023年 | 6篇 |
2022年 | 14篇 |
2021年 | 26篇 |
2020年 | 18篇 |
2019年 | 19篇 |
2018年 | 30篇 |
2017年 | 19篇 |
2016年 | 24篇 |
2015年 | 21篇 |
2014年 | 19篇 |
2013年 | 43篇 |
2012年 | 48篇 |
2011年 | 48篇 |
2010年 | 43篇 |
2009年 | 30篇 |
2008年 | 40篇 |
2007年 | 40篇 |
2006年 | 48篇 |
2005年 | 49篇 |
2004年 | 38篇 |
2003年 | 29篇 |
2002年 | 36篇 |
2001年 | 18篇 |
2000年 | 10篇 |
1999年 | 16篇 |
1998年 | 6篇 |
1997年 | 6篇 |
1996年 | 4篇 |
1995年 | 3篇 |
1994年 | 2篇 |
1993年 | 7篇 |
1992年 | 4篇 |
1991年 | 7篇 |
1990年 | 5篇 |
1989年 | 9篇 |
1988年 | 13篇 |
1987年 | 8篇 |
1986年 | 7篇 |
1985年 | 5篇 |
1984年 | 4篇 |
1983年 | 10篇 |
1982年 | 2篇 |
1981年 | 3篇 |
1980年 | 5篇 |
1979年 | 5篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1976年 | 10篇 |
1974年 | 1篇 |
排序方式: 共有865条查询结果,搜索用时 31 毫秒
31.
Mercede Erfanian Christiana Kartsonaki Azita Keshavarz 《Nordic journal of psychiatry》2013,67(4-5):219-228
AbstractObjective: Misophonia is a neurophysiological disorder, phenotypically characterized by heightened autonomic nervous system arousal which is accompanied by a high magnitude of emotional reactivity to repetitive and pattern-based auditory stimuli. This study identifies the prevalence of psychiatric symptoms in misophonia sufferers, the association between severity of misophonia and psychiatric symptoms, and the association between misophonia severity and gender. Methods: Fifty-two misophonia sufferers, 30 females (mean age?=?40.93 ± 15.29) and 22 males (mean age?=?51.18 ± 15.91) were recruited in our study and they were diagnosed according the criteria proposed by Schröder et al. The participants were evaluated by the A-MISO-S for the severity of misophonia and the MINI to assess the presence of psychiatric symptoms. Results: The most common comorbid symptoms reported by the misophonia patients were respectively PTSD (N?=?8, 15.38%), OCD (N?=?6, 11.53%), MDD (N?=?5, 9.61%), and anorexia (N?=?5, 9.61%). Misophonia severity was associated with the symptoms of MDD, OCD, and PTSD as well as anorexia. There was an indication of a significant difference between men and women in the severity of misophonic symptoms. Conclusion: Our findings highlight the importance of recognizing psychiatric comorbidity among misophonia sufferers. The presence of these varying psychiatric disorders’ features in individuals with misophonia suggests that while misophonia has unique clinical characteristics with an underlying neurophysiological mechanism, may be associated with psychiatric symptoms. Therefore, when assessing individuals with misophonia symptoms, it is important to screen for psychiatric symptoms. This will assist researchers and clinicians to better understand the nature of the symptoms and how they may be interacting and ultimately allocating the most effective therapeutic strategies. 相似文献
32.
Marjorie Nightingale Christiana Ibilola Awosan Katherine Stavrianopoulos 《Journal of family psychotherapy》2013,24(3):221-244
ABSTRACTThis article discusses unique considerations for a culturally sensitive emotionally focused therapy (EFT) for African American couples. EFT is an empirically supported treatment that significantly reduces relationship distress, yet efficacy with diverse populations remains unknown. African Americans’ chronic exposure to racism and discrimination creates a cumulative racial stress that negatively impacts their couple relationships. We propose a racially sensitive intervention for African American couples that addresses five considerations most salient for successful EFT treatment: the impact of racial stress, client trust of the therapist, gender-role expectations, and racial–gender views of emotionality and vulnerability. A case study illustrates this approach. 相似文献
33.
Boesl Fabian Allers Kristina Herm Juliane Scheider Thomas Franke Christiana 《Journal of neurovirology》2022,28(2):335-338
Journal of NeuroVirology - Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease of the CNS caused by the human polyomavirus 2 (JCV). PML predominantly occurs in... 相似文献
34.
35.
Lower body mass index and atrial fibrillation as independent predictors for mortality in patients with implantable cardioverter defibrillator 总被引:1,自引:0,他引:1 下载免费PDF全文
Aim
To evaluate risk factors related to total mortality in an unselected population of patients implanted with a cardioverter defibrillator.Methods
Survival analysis was performed retrospectively investigating the records of 77 consecutive patients implanted with defibrillators (median 67 years, range 38-83 years; 63 men). All patients were followed regularly in 3-month intervals. The cause of mortality was assessed clinically, including post-mortem examination of device to assess possible arrhythmogenic death. Predictors were evaluated by Kaplan-Meier analysis with log-rank tests and by Cox regression analysis (proportional hazards).Results
Defibrillator recipients had a mean (±SD) ejection fraction of 34 ± 13%, left ventricular end-diastolic dimension (LVEDD) of 6.24 ± 0.8 cm, QRS duration of 129 ± 34 ms, and body mass index (BMI) of 26.4 ± 4.3 kg/m2. Atrial fibrillation was present in 32 patients, paroxysmal fibrillation in 23, and permanent fibrillation in 9 patients. The estimate of mean survival time for all patients was 51.5 (95% confidence interval 46.6-56.5) months. During the study period 11/77 (14%) patients died. Mean follow-up time was 24.5 months (range 0.2-60.7) for survivors and 7.6 months (range 1.5-42) for non-survivors. Independent predictors of mortality were the NYHA class (P = 0.004), BMI≤26 kg/m2 (P = 0.024), presence of paroxysmal or permanent atrial fibrillation (P = 0.014), and absence of arterial hypertension (P = 0.010). LVEDD showed a weak significant effect on survival (P = 0.049).Conclusion
Patients with implantable cardioverter defibrillator and a normal to lower BMI or atrial fibrillation had a significantly higher overall mortality. These factors may be indicative of end stage heart failure or diseases associated with high sympathetic activation.Patients with implantable cardioverter defibrillator, in addition to an intrinsic residual risk of sudden cardiac death due to a reduced effectiveness of defibrillators, have a high incidence of co-morbidities, which increase mortality in this population. Several studies have demonstrated that the implantation of a cardioverter defibrillator for both secondary and primary prevention significantly reduces total mortality by preventing sudden cardiac death (1-3). However, the death rate from non-arrhythmic causes among patients with implantable cardioverter defibrillator is substantial (4) and deserves further investigation. The purpose of this study was to investigate various risk factors with respect to total mortality in an unselected population of patients with implanted cardioverter defibrillator devices. 相似文献36.
Kehinde AO Obaseki FA Ishola OC Ibrahim KD 《Journal of the National Medical Association》2007,99(10):1185-1189
OBJECTIVE: The magnitude of drug-resistant Mycobacterium tuberculosis infection (MDR-TB) in Nigeria, the most populous country in sub-Saharan Africa, is largely unknown. This information would assist policymakers to develop intervention strategies against tuberculosis (TB) in the country. MATERIALS AND METHODS: This is a one-year laboratory-based study. Specimens from suspected new TB patients sent to the TB laboratory of the Department of Medical Microbiology, University College Hospital Ibadan, Nigeria from May 1, 2005 to April 27, 2006 were processed and analyzed. The specimens were stained with Ziehl-Neelsen (Z-N) reagents and cultured on Lowenstein-Jensen medium, incubated at 37 degrees C for 6-8 weeks. Isolates were confirmed as MDR-TB by Z-N reactions and biochemical methods. Drug susceptibility to streptomycin, ethambutol, rifampicin and isoniazid was done using Bactec 460 TB radiometric method. RESULTS: Of the 1,120 specimens processed, 80 (7.1%) were smear positive, while 56 (5.0%) were culture positive, even though the association was not statistically significant (p > 0.05). Culture contamination rate was 8.8%. Thirty (53.6%) of the culture positive isolates were resistant to both isoniazid and rifampicin, while 26 (46.4%) were susceptible. About half--53.3%--of the resistant isolates were from the antiretroviral clinic, while 10 (33.4%) were from peripheral centers. CONCLUSION: This study shows that MDR-TB is emerging in Nigeria. Further studies on MDR-TB are urgently needed in the country to ascertain the magnitude of the problem and to proffer solutions to it. 相似文献
37.
38.
Marilyn S. Townsend Mical K. Shilts Dennis M. Styne Christiana Drake Louise Lanoue Lenna Ontai 《Journal of nutrition education and behavior》2018,50(7):705-717
Objective
Demonstrate validity and reliability for an obesity risk assessment tool for young children targeting families' modifiable home environments.Design
Longitudinal design with data collected over 100 weeks.Setting
Head Start and the Special Supplemental Nutrition Program for Women, Infants, and Children.Participants
Parent–child pairs (n?=?133) provided food behavior assessments; 3 child-modified, 24-hour dietary recalls; 3?≥?36-hour activity logs; and measured heights and weights.Main Outcome Measure
Five measures of validity and 5 of reliability.Results
Validity was excellent for the assessment tool, named Healthy Kids, demonstrating an inverse relationship with child body mass index percentile-for-age (P?=?.02). Scales were significantly related to hypothesized variables (P?≤?.05): fruit or vegetable cup equivalents; folate; vitamins A, C, and D; β-carotene; calcium; fiber; sugar; screen, sleep, and physical activity minutes; and parent behaviors. Measures of reliability were acceptable.Conclusions and Implications
Overall, children with higher Healthy Kids scores had a more healthful profile as well as lower body mass index percentiles-for-age 1.5 years later. Healthy Kids has potential for use by nutrition professionals as a screening tool to identify young children most at risk for excess weight gain, as an evaluation to assess intervention impact, and as a counseling tool to tailor intervention efforts. Future research should include validation in other settings and with other populations. 相似文献39.
Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells 总被引:8,自引:1,他引:8 下载免费PDF全文
Indoleamine-2,3-dioxygenase (IDO) and tryptophanyl-tRNA-synthetase (TTS) are interferon-gamma (IFN-gamma)-inducible enzymes that are responsible for tryptophan degradation and for its use in protein synthesis, respectively. IFN-gamma-induced IDO has immunomodulatory properties in murine and human models. A concomitant increase of TTS has been postulated to protect the IDO-expressing cells from tryptophan catabolism. IDO can be induced in dendritic cells (DCs) by recombinant soluble cytotoxic T lymphocyte antigen-4 (CTLA-4-Fc). We investigated the effects of CTLA-4-Fc on IDO and TTS mRNA expression in human peripheral blood mononuclear cells (PBMCs) and isolated leukocyte subsets. CTLA-4-Fc exposure induced increased IDO and TTS expression in unseparated PBMCs, as well as in monocyte-derived mature DCs. CD4(+) T cells isolated from CTLA-4-Fc-treated PBMCs showed increased IDO and TTS compared with untreated cells. CD8(+) T cells from CTLA-4-Fc-treated PBMCs expressed increased levels of TTS but not IDO. Pretreatment of PBMCs with CTLA-4-Fc inhibited the activation of CD4(+) T cells induced by influenza A virus (Flu) or phytohemagglutinin A (PHA), but had no effect on CD8(+) T cells. This is the first report of IDO and TTS regulation by the CTLA-4-B7 system in human CD4(+) and CD8(+) T cells, and raises the possibility that these 2 tryptophan-modulating enzymes provide an important mechanism for regulating immune responses. 相似文献