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Chloe Grimmett John Bridgewater Andrew Steptoe Jane Wardle 《Quality of life research》2011,20(8):1237-1245
Purpose
As cancer survival rates improve, there is growing interest in the role of lifestyle in longer-term health and quality of life (QoL). This study examined the prevalence of health-related behaviours, and the associations between health behaviours and QoL, in colorectal cancer survivors. 相似文献133.
Analysis of inborn errors of metabolism: disease spectrum for expanded newborn screening in Hong Kong 总被引:1,自引:0,他引:1
Lee HC Mak CM Lam CW Yuen YP Chan AO Shek CC Siu TS Lai CK Ching CK Siu WK Chen SP Law CY Tai HL Tam S Chan AY 《中华医学杂志(英文版)》2011,124(7):0983-0989
Background Data of classical inborn errors of metabolism (IEM) of amino acids, organic acids and fatty acid oxidation are largely lacking in Hong Kong, where mass spectrometry-based expanded newborn screening for IEM has not been initiated. The current study aimed to evaluate the approximate incidence, spectrum and other characteristics of classical IEM in Hong Kong, which would be important in developing an expanded newborn screening program for the local area.
Methods The laboratory records of plasma amino acids, plasma acylcarnitines and urine organic acids analyses from year 2005 to 2009 inclusive in three regional chemical pathology laboratories providing biochemical and genetic diagnostic services for IEM were retrospectively reviewed.
Results Among the cohort, 43 patients were diagnosed of IEM, including 30 cases (69%) of amino acidemias (predominantly citrin deficiency, hyperphenylalaninemia due to 6-pyruvoyl-tetrahydropterin synthase deficiency and tyrosinemia type I), 5 cases (12%) of organic acidemias (predominantly holocarboxylase synthetase deficiency) and 8 cases (19%) of fatty acid oxidation defects (predominantly carnitine-acylcarnitine translocase deficiency). The incidence of classical IEM in Hong Kong was roughly estimated to be at least 1 case per 4122 lives births, or 0.243 cases per 1000 live births. This incidence is similar to those reported worldwide, including the mainland of China. The estimated incidence of hyperphenylalaninemia was 1 in 29 542 live births.
Conclusions Our data indicate that it is indisputable for the introduction of expanded newborn screening program in Hong Kong. Since Hong Kong is a metropolitan city, a comprehensive expanded newborn screening program and referral system should be available to serve the neonates born in the area.
相似文献
134.
I am smart, therefore I can: examining the relationship between IQ and self-efficacy across cultures
Jurecska DE Lee CE Chang KB Sequeira E 《International journal of adolescent medicine and health》2011,23(3):209-216
The purpose of this article is to examine the relationship between intelligence (IQ) and self-efficacy in children and adolescents living in the United States and Nicaragua. The sample consisted of 90 (46 male, 44 female) students (mean age = 11.57 years, SD = 3.0 years) referred by school administrators and faculty. United States (US) participants (n = 27) resided in rural counties in the Northwest. The other group consisted of 63 students from Central America. A comparison between groups revealed that in the US, sample higher grades and IQ scores are typically associated with higher levels of self-efficacy. However in the Nicaraguan sample, both IQ scores and grades were not associated with self-efficacy, although age was correlated with self-efficacy. Results suggest that the construct of self-efficacy might change depending on whether one belongs to an individualistic or collectivistic society. Additionally, the effects of socioeconomic factors might influence perceived ability even more than intellectual abilities. 相似文献
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An Innovative Oat‐Based Sterile Emollient Cream in the Maintenance Therapy of Childhood Atopic Dermatitis
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Valerie Mengeaud Ph.D Chloe Phulpin Pharm.D. Adeline Bacquey C.R.A. Franck Boralevi M.D. Anne‐Marie Schmitt M.D. Alain Taieb M.D. 《Pediatric dermatology》2015,32(2):208-215
Although emollients are recommended in the management of atopic dermatitis (AD), regimens for emollient maintenance therapy are awaiting validation. We conducted an international, multicenter, open‐label trial to assess the effects of a 3‐month maintenance treatment regimen with a sterile, preservative‐free emollient cream containing oat plantlets in children (ages 6 mos–6 yrs) with moderate AD. After a 14‐day run‐in stabilization phase using a topical corticosteroid (TCS) treatment of medium potency, 108 children with a SCORing Atopic Dermatitis (SCORAD) index of 20 or less were included in the study. Emollient was applied twice daily for 3 months. Rescue TCS treatment was used only in cases of flare‐ups. The SCORAD index, Patient‐Oriented SCORAD (PO‐SCORAD) index, number of flares, TCS use, and tolerance were assessed at months 1, 2, and 3 (M1, M2, M3). AD severity improved, with a highly significant decrease in the SCORAD and PO‐SCORAD indexes at M2 and M3 (p < 0.001). Changes from baseline to M3 were 48.6 ± 73.6% for SCORAD and 29.6 ± 125.3% for PO‐SCORAD. The number of flares and TCS use significantly decreased by M3 (both p < 0.001). Very good tolerance was recorded in 100% of children at M2 and M3. Notwithstanding the limitations inherent in open‐label trials, twice daily application of the oat‐based sterile emollient cream led to a significant improvement of clinical symptoms, evidenced by parallel changes in the SCORAD and PO‐SCORAD indexes and fewer flare‐ups. Clinical benefit and less TCS use were maintained at M3. Tolerance was very good. 相似文献
140.
Thomas N. Denny Laura Andrews Mattia Bonsignori Kyle Cavanaugh Michael B. Datto Anastasia Deckard C. Todd DeMarco Nicole DeNaeyer Carol A. Epling Thaddeus Gurley Steven B. Haase Chloe Hallberg John Harer Charles L. Kneifel Mark J. Lee Raul Louzao M. Anthony Moody Zack Moore Christopher R. Polage Jamie Puglin P. Hunter Spotts John A. Vaughn Cameron R. Wolfe 《MMWR. Morbidity and mortality weekly report》2020,69(46):1743