12例急性砷化氢中毒救治的临床分析

急性砷化氢中毒病死率较高,尤其并发多器官功能衰竭。我院自1998年5月-2006年9月共收治12例铅锌矿矿石处理工由于防护不当所致急性吸入性砷化氢中毒病人,经血液净化及换血、激素、保肝利尿等综合治疗后,10例治愈,2例死亡。现将救治体会报告如下。     

转Xa21基因大米亚慢性毒性实验

目的　观察Xa2 1转基因大米对大鼠的亚慢性毒性损害。方法　将Wistar大鼠按性别体重随机分为转基因大米组、非转基因大米组和AIN93G正常对照组。分别饲相应饲料 90天 ,自由进食。观察大鼠体重、身长、血常规、血生化、脏器重量、骨密度和脏器的病理学检查。结果　与非转基因大米组相比 ,实验中期转基因大米组血糖降低 ,胆固醇和高密度脂蛋白升高 ,实验结束时上述差异消失 ,但雌性组谷草转氨酶活性显著升高。与AIN93G正常对照组相比 ,实验中期转基因大米组体重、甘油三酯、高密度脂蛋白显著增高 ,血糖降低 ;实验结束时上述差异消失。脑、心、脾、肺、肾、胃、十二指肠、肾上腺、睾丸、卵巢病理检查未见异常。结论　现有实验结果不能证实转基因大米对大鼠有亚慢性毒性作用     

抗氧化微量营养素对IDDM小鼠抗氧化损伤的实验研究

目的:研究复合抗氧化微量营养素(antioxidative micronutrients,AM)拮抗IDDM小鼠氧化侵袭损害的作用机制。方法:用一次大剂量注射2%四氧嘧啶(alloxan)的方法制备IDDM小鼠模型,联合给予硒(Se)、维生素E(VE)、钒(V)、铬(Cr),测定脾活性氧(ROS)水平以及心、脑、肾中MDA含量和GSH-Px、SOD、GSH-ST活性。结果:IDDM小鼠脾ROS水平以及心、脑MDA含量明显增高(P<0.01),而肾中SOD活性明显降低(P<0.01);联合应用AM可降低IDDM小鼠脾ROS水平及心、脑MDA含量,并提高心GSH-Px、肾SOD及心、肾GSH-ST活性。结论:联合应用AM可在一定程度上拮抗IDDM时的氧化侵袭损害,对防治糖尿病微血管病变以及并发症有重要意义。     

A pH-sensitive supramolecular nanosystem with chlorin e6 and triptolide co-delivery for chemo-photodynamic combination therapy

The combination of Ce6, an acknowledged photosensitizer, and TPL, a natural anticancer agent, has been demonstrated as a useful strategy to reinforce the tumor growth suppression, as well as decrease the systemic side effects compared with their monotherapy. However, in view of the optimal chemo-photodynamic combination efficiency, there is still short of the feasible nanovehicle to steadily co-deliver Ce6 and TPL, and stimuli-responsively burst release drugs in tumor site. Herein, we described ...     

二羧乙基锗倍半氧化物（Ge－132）对肝枯否细胞免疫及酶活性的影响

探讨了二羧乙基锗倍半氧化物（Ｇｅ－１３２）对肝枯否细胞免疫及酶活性的影响，二羧乙基锗倍半氧化物在体外实验中明显地对抗四氯化碳对大鼠肝枯否细胞的损害、明显增加花环形成率、吞噬率及吞噬指数，而且显著增加过氧化物小体、过氧化物酶、琥珀酸脱氢酶活性．实验结果表明，四氯化碳可以损伤肝枯否细胞，二羧乙基锗倍半氧化物（Ｇｅ－１３２）可保护和修补四氯化碳的细胞损伤．     

Monotropein Improves Dexamethasone-Induced Muscle Atrophy via the AKT/mTOR/FOXO3a Signaling Pathways

The present study aimed to investigate the effects of monotropein (MON) on improving dexamethasone (DEX)-induced muscle atrophy in mice and C2C12 mouse skeletal muscle cells. The body weights, grip strengths, and muscle weights of mice were assessed. The histological change in the gastrocnemius tissues was also observed through H&E staining. The expression of myosin heavy chain (MyHC), muscle ring finger 1 (MuRF1), and muscle atrophy F-box (Atrogin1) and the phosphorylation of AKT, mTOR, and FOXO3a in the muscle tissues of mice and C2C12 myotubes were analyzed using Western blotting. MON improved muscle atrophy in mice and C2C12 myotubes by regulating catabolic states via the AKT/mTOR/FOXO3a signaling pathways, and enhanced muscle function by the increases of muscle mass and strength in mice. This suggests that MON could be used for the prevention and treatment of muscle atrophy in patients.     

Dietary Micronutrient Status and Relation between Micronutrient Intakes and Overweight and Obesity among Non-Pregnant and Non-Lactating Women Aged 18 to 49 in China

Women between the ages of 18 and 49 are women of reproductive age, for whom physical health and nutritional status are closely related to successful pregnancy, good pregnancy outcomes and the nurturing of the next generation. Overweight and obesity have become important nutrition and health problems of women aged 18–49 years in China. In social life, non-pregnant and non-lactating Chinese women aged 18–49 are the most vulnerable and neglected group. At present, there are no research data on their dietary micronutrient intake, and the relationship between dietary micronutrient intake and overweight and obesity in China. However, non-pregnant and non-lactating women aged 18–49 are the best window of opportunity to implement strategies, correct nutrition and improve physical health. It remains to be explored whether their overweight and obesity are related to inadequate dietary micronutrient intake. The aim of this study was to evaluate dietary micronutrient intake in non-pregnant and non-lactating Chinese women aged 18–49 years, and to analyze the relationship between dietary micronutrient intake and overweight and obesity. Data were obtained from 2015 China Adult Chronic Disease and Nutrition Surveillance (CACDNS 2015). In CACDNS 2015, 12,872 women aged 18 to 49 years (excluding pregnant women and lactating mothers) were surveyed for a three-day 24 h dietary recall and a three-day household weighing of edible oil and condiments. The average daily dietary intake of micronutrients was calculated according to the Chinese food composition table. In 2015, the median intake of vitamin A, vitamin B₁, vitamin B₂, vitamin C and folate in non-pregnant and non-lactating women aged 18–49 years in China was 267.0 μg RE/day, 0.7 mg/day, 0.6 mg/day, 63.5 mg/day and 121.0 μg/day, respectively. The median mean intake of vitamin A, niacin, calcium and zinc in overweight/obese group was lower than that in non-overweight/obese group, and the difference was statistically significant (p < 0.05). Multivariate Logistic regression analysis showed that vitamin A intake (Q3 vs. Q1: OR = 0.785, 95% CI: 0.702~0.878; Q4 vs. Q1: OR = 0.766, 95% CI: 0.679~0.865), niacin intake (Q2 vs. Q1: OR = 0.801, 95% CI: 0.715–0.898; Q3 vs. Q1: OR = 0.632, 95% CI: 0.554~0.721; Q4 vs. Q1: OR = 0.662, 95% CI: 0.568~0.772), Zinc intake (Q4 vs. Q1: OR = 0.786, 95% CI: 0.662~0.932) were a protective factor for overweight/obesity in women, while vitamin B₂ intake (Q2 vs. Q1: OR = 1.256, 95% CI: 1.120~1.408; Q3 vs. Q1: OR = 1.416, 95% CI: 1.240~1.617; Q4 vs. Q1: OR = 1.515, 95% CI: 1.293–1.776), vitamin E intake (Q2 vs. Q1: OR = 1.114, 95% CI: 1.006–0.235; Q3 vs. Q1: OR = 1.162, 95% CI: 1.048~0.288; Q4 vs. Q1: OR = 1.234, 95% CI: 1.112–1.371) was a risk factor for overweight/obesity in females. The intakes of most dietary micronutrients in non-pregnant and non-lactating women aged 18–49 in China were low. The intakes of dietary vitamin A, niacin and zinc were negatively correlated with the risk of overweight/obesity, while the intakes of vitamin B₂ and vitamin E were positively correlated with the risk of overweight/obesity.     

人发角蛋白导管修复周围神经缺损的实验研究

目的 探索用人发角蛋白（HHK）制成的导管对大段缺损的周围神经的修复效果。方法 将25只新西兰兔分成3组，对照组不接受手术；另2组切除胫神10mm，分别用缝合线（无HHK组）和HHK导管（HHK组）连接神经两断功能恢复快，解剖观察发现，神经两断端之间以及HHK导管的腔隙被白色新生组织充满，人发部分消失，残余的人发易脆易断。在光镜下可见人发周围大量再生的雪旺细胞和较幼稚的神经纤维，神经纤维无序 排列，人发被初步降解，术后1年，人发被完全降解。神经缺损部位修复完好。结论 HHK导管可诱导神经纤维再生，跨过10mm的缺损间隙，从而修复神经缺损，HHK是制作神经导管的较为理想的材料。     

研究肝癌介入术后辅以中药治疗肝脏微循环的变化

目的 采用CT灌注成像方法,研究肝癌介入术后辅以中药治疗肝脏微循环的变化.方法 将患者分为治疗组(介入加中药)、对照组(单纯介入);每组30例.使用Light speed 16 层CT机,对患者行CT灌注扫描,扫描应用MSCT的" Toggling-table"技术.数据采用单因素方差分析,肝癌组织的感兴趣区选择为介入治疗后无碘油沉积的区域.灌注成像参数为:平均通过时间(MTT),肝血流量(BF)、血容量 (BV)、血管表面通透性 (PS)和肝动脉灌注分数(HAF).结果 肝癌组织,中药组和非中药组在BF、BV上存在显著性差异.相对正常肝组织,同侧肝组织:中药组和非中药组在BF、BV、MTT、PS上存在显著性差异.中药组,同侧肝组织和对侧肝组织在BF、BV上存在显著性差异.结论 肝癌介入治疗后运用中药配合治疗,可提高肝癌患者的生活质量、减轻临床症状、改善体征.肝癌灌注成像作为一种无创、简单、快速的功能性成像方法,在显示解剖细节同时,还能提供肿瘤各部位的血流灌注信息,为评价栓塞和中药疗效提供了一个新方法.