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61.
Background : A retrospective analysis of 103 case records from 1978 to 1996 with a provisional diagnosis of Buerger's disease was undertaken at the Department of Surgery, University of Hong Kong, Queen Mary Hospital. The aim of the study was to elucidate the clinical course and evaluate the results of surgical intervention of Buerger's disease in Hong Kong Chinese people. Methods : Fourteen patients were subsequently excluded from the study because of inability to fulfil our diagnostic criteria. Data on clinical presentation, investigations, indications and results of surgical intervention were reviewed. Sympathectomies and arterial reconstructions were performed on 42 and four patients, respectively, for critical ischaemia or rest pain. Outcome was analysed with respect to the rate of ulcer healing, pattern of recurrence and limb loss. Results : The patients were all young male heavy smokers with a mean age of 36.5 years. The majority of patients (80%) presented with ischaemic ulceration or gangrene. Vascular reconstruction was undertaken in four patients and satisfactory long-term results were obtained in three patients. Sympathectomy was able to relieve symptoms in 87% of operated patients and ischaemic ulceration healed in 2.6 (mean) ± 1.7 (SD) months after the operation. If the patient continued to smoke, surgical intervention did not exempt the patient from a relapse or amputation. Conclusion : Sympathectomy provides short-term pain relief and promotes ulcer healing in patients with Buerger's disease but carries no long-term benefit. Complete abstinence from smoking is the only means of arresting the progression of the disease. 相似文献
62.
作者综述了10年来对Duchenne型肌营养不良症(DMD)的研究概况。主要包括①DMD的临床研究。②血清生化研究表明CK、LDH、Mb是诊断DMD病人和携带者的敏感指标。③心脏无创性检测和肌肉超微结构研究。④部分抗肌萎缩蛋白基因YAC物理图谱,精细限制酶图谱和缺失热区的核苷酸顺序分析,首次发现内含子中AT富集区的同源顺序与DMD断裂有关。⑤抗肌萎缩蛋白的缺失热区疏水肽段存在与否与DMD发病密切相关。 相似文献
63.
本文用中草药红背丝绸醇提物、乙酸乙脂提取物和单体CA-1201 三种不同成分对ET-1 在动物整体及离体水平生物学效应的拮抗作用进行了研究。结果发现:这三种成分对ET-1 致小鼠进行死亡有保护作用,使得小鼠的死亡率及死亡数下降;并可拮抗ET-1 致胸主动脉的缩血管效应,醇提物和乙酸乙脂提取物(10- 7母液)拮抗ET 缩血管效应分别为57.27% 和58.61% ;CA-1201 10- 8和10- 9 M 亦能拮抗ET-1 的缩血管效应;醇提物和乙酸乙脂提取物口服及CA-1201 静脉注射后能拮抗ET-1 的升压作用,拮抗ET-1 作用均呈现明显的剂量依赖性。提示中草药红背丝绸不同成分可拮抗ET-1 的生物学效应。 相似文献
64.
对16例垂体腺瘤采用单侧鼻前庭切口经蝶切除,效果满意,既可减少手术创伤,又缩短了手术距离,且避免了美容缺陷,是一种设计巧妙,较为实用的手术方法,尤其适用于生长激素腺瘤。 相似文献
65.
S Kimel L O Svaasand M Hammer-Wilson V Gottfried S Cheng E Svaasand M W Berns 《Lasers in surgery and medicine》1992,12(4):432-440
The chick chorioallantoic membrane (CAM) model was used to study vascular effects of photodynamic therapy (PDT) and hyperthermia (HPT) and the synergism of these modalities. The CAM is a convenient medium for monitoring the modifications of the vasculature. It is possible to view the CAM and to examine structural changes of individual blood vessels in real time. Moreover, the CAM is a closed system which lends itself to mathematical modeling of the temporal and spatial temperature profile and in which HPT can be performed quantitatively and to a selected depth, using different lasers. A porphyrin-type photosensitizer solution was applied to areas of the CAM, defined by teflon O-rings placed on the surface. Uptake dynamics of the sensitizer into the CAM was determined by analyzing its fluorescence in vivo. The CAM area was irradiated with a dual-wavelength laser system composed of a dye laser at 644 nm (to induce PDT) and a CO2 laser at 10.6 microns (to bring about HPT). Damage to the CAM vasculature, due to combined PDT+HPT, was compared to the outcome of the separate modalities, and a synergistic effect of about 40% was observed. 相似文献
66.
以辣根过氧化物酶(PO)和抗-PO作为免疫沉淀中的抗原和抗体,用光电比色法,对78例小儿肾脏疾病血清补体对免疫沉淀的抑制作用(IIPC)进行了研究,并同时检测补体成分C3、C4。结果,正常对照IIPCOD值为0.505±0.085,急性肾小球肾炎(0.137±0.108)显著降低(P<0.001);慢性肾小球肾炎(0.470±0.053)改变不明显(P>0.05);肾病综合征(0.401±0.038)明显低下(P<0.05)。IIPC低下的发生率依次为急性肾小球肾炎(83%)、肾病综合征(43%)、慢性肾小球肾炎(32%)。表明小儿肾小球疾病时IIPC大多降低并与疾病的活动性有关。因此认为IIPC低下在肾脏病的发生和发展中起一定作用。 相似文献
67.
68.
A W Chiu M T Chen W J Huang S T Young C Cheng S W Huang C L Chu L S Chang 《European urology》1992,22(3):250-254
Laparoscopic nephrectomy was performed in 15 male pigs, the procedure was successful in 14. Extraction of the intact kidney through a 5-cm lower abdomen incision was done in 7 animals; complete destruction and evacuation of the kidney was accomplished by a round-knife suction device through a 1-cm port in another 7 pigs. Grossly, the specimen consisted of sausage-like tubular renal tissue and a small amount of tissue debris. Pathology revealed that the glomerular and tubular structures were well preserved, no interstitial hematoma could be found. Four ports were usually used, one 1-cm umbilical camera port, one 0.5-cm port for ureter traction, and two 1-cm working ports along the midclavicular line. All the pigs recovered uneventfully. The average operation time was 3 h 20 min. The application of endo-GIA (United States Surgical Corporation) for renal hilum reduced the operative time to 2 h 20 min. Complications included renal vein tear during endoclip application and cutting in the first case, mild subcutaneous emphysema in 2 cases. This first pig received exploratory laparotomy for the repair and ligation of the renal vein. No more major complications occurred with increasing experience. From this porcine experiment, we conclude that the combination of laparoscopy, a tissue destroyer and an endobag for the entrapment of kidney seem to be a promising technique for clinical nephrectomy. 相似文献
69.
目的研究杜氏/贝氏进行性肌营养不良(DMD/BMD)携带者视网膜眼电图(ERG)的改变,探讨ERG对DMD/BMD携带者的诊断意义。方法对22个基因突变类型明确的DMD/BMD家系.用定量PCR法结合系谱分析将家系中女性成员分成肯定携带者和非携带者,对患者和家系女性成员进行详细的眼科检查和ERG检测,并用ERG国际测量标准记录结果。结果22名患者中17名出现异常ERG改变;11名肯定携带者中5名出现ERG异常,14名非携带者无ERG改变,两组无重叠。结论ERG是一项对DMD/BMD诊断非常敏感和特异的检查,而ERG对携带者的诊断也具有一定的临床意义。 相似文献
70.