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Anne M. Connolly Julaine M. Florence Mary M. Cradock Elizabeth C. Malkus Jeanine R. Schierbecker Catherine A. Siener Charlie O. Wulf Pallavi Anand Paul T. Golumbek Craig M. Zaidman J. Philip Miller Linda P. Lowes Lindsay N. Alfano Laurence Viollet-Callendret Kevin M. Flanigan Jerry R. Mendell Craig M. McDonald Erica Goude Michelle Eagle 《Neuromuscular disorders : NMD》2013,23(7):529-539
Therapeutic trials in Duchenne Muscular Dystrophy (DMD) exclude young boys because traditional outcome measures rely on cooperation. The Bayley III Scales of Infant and Toddler Development (Bayley III) have been validated in developing children and those with developmental disorders but have not been studied in DMD. Expanded Hammersmith Functional Motor Scale (HFMSE) and North Star Ambulatory Assessment (NSAA) may also be useful in this young DMD population. Clinical evaluators from the MDA-DMD Clinical Research Network were trained in these assessment tools. Infants and boys with DMD (n = 24; 1.9 ± 0.7 years) were assessed. The mean Bayley III motor composite score was low (82.8 ± 8; p ? .0001) (normal = 100 ± 15). Mean gross motor and fine motor function scaled scores were low (both p ? .0001). The mean cognitive comprehensive (p = .0002), receptive language (p ? .0001), and expressive language (p = .0001) were also low compared to normal children. Age was negatively associated with Bayley III gross motor (r = ?0.44; p = .02) but not with fine motor, cognitive, or language scores. HFMSE (n = 23) showed a mean score of 31 ± 13. NSAA (n = 18 boys; 2.2 ± 0.4 years) showed a mean score of 12 ± 5. Outcome assessments of young boys with DMD are feasible and in this multicenter study were best demonstrated using the Bayley III. 相似文献
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Charlie C. Park Catherine Hooker Jonathan C. Hooker Emily Bass William Haufe Alexandra Schlein Yesenia Covarrubias Elhamy Heba Mark Bydder Tanya Wolfson Anthony Gamst Rohit Loomba Jeffrey Schwimmer Diego Hernando Scott B. Reeder Michael Middleton Claude B. Sirlin Gavin Hamilton 《Journal of magnetic resonance imaging : JMRI》2019,49(1):229-238
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On the discrepancies between Monte Carlo dose calculations and measurements for the 18 MV varian photon beam 总被引:1,自引:0,他引:1
Significant discrepancies between Monte Carlo dose calculations and measurements for the Varian 18 MV photon beam with a large field size (40 x 40 cm2) were reported by different investigators. In this work, we investigated these discrepancies based on a new geometry model ("New Model") of the Varian 21EX linac using the GEPTS Monte Carlo code. Some geometric parameters used in previous investigations (Old Model) were inaccurate, as suggested by Chibani in his AAPM presentation (2004) and later confirmed by the manufacturer. The entrance and exit radii of the primary collimator of the New Model are 2 mm larger than previously thought. In addition to the corrected dimensions of the primary collimator, the New Model includes approximate models for the lead shield and the mirror frame between the monitor chamber and the Y jaws. A detailed analysis of the phase space data shows the effects of these corrections on the beam characteristics. The individual contributions from the linac component to the photon and electron fluences are calculated. The main source of discrepancy between measurements and calculations based on the Old Model is the underestimated electron contamination. The photon and electron fluences at the isocenter are 5.3% and 36% larger in the New Model in comparison with the Old Model. The flattening filter and the lead shield (plus the mirror frame) contribute 48.7% and 13% of the total electron contamination at the isocenter, respectively. For both open and filtered (2 mm Pb) fields, the calculated (New Model) and measured dose distributions are within 1% for depths larger than 1 cm. To solve the residual problem of large differences at shallow depths (8% at 0.25 cm depth), the detailed geometry of an IC-10 ionization chamber was simulated and the dose in the air cavity was calculated for different positions on the central axis including at the surface, where half of the chamber is outside the phantom. The calculated and measured chamber responses are within 3% even at the zero depth. 相似文献
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Jose Paulo P. Lorenzo Ma. Hanna Monica Z. Sollano Evelyn O. Salido Julie Li-Yu Sandra A. Tankeh-Torres Ida Ayu Ratih Wulansari Manuaba Md Mujibur Rahman Binoy J. Paul Mo Yin Mok Monika De Silva Prasanta Padhan Ai Lee Lim Melvin Marcial Jennifer Jeanne Vicera Syed Atiqul Haq Sami Salman Chiranthi K. Liyanage Helen I. Keen Cheng Yew Kuang James Cheng-Chung Wei Rakhma Yanti Hellmi Charlie E. Chan Worawit Louthrenoo 《International journal of rheumatic diseases》2022,25(1):7-20
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Hooker Jonathan C. Hamilton Gavin Park Charlie C. Liao Steven Wolfson Tanya Dehkordy Soudabeh Fazeli Hong Cheng William Mamidipalli Adrija Gamst Anthony Loomba Rohit Sirlin Claude B. 《Abdominal imaging》2019,44(2):482-492
Abdominal Radiology - To determine the inter-reader agreement of magnetic resonance imaging proton density fat fraction (PDFF) and its longitudinal change in a clinical trial of adults with... 相似文献