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161.
162.
Transjugular liver biopsy with an automated device 总被引:2,自引:1,他引:1
163.
Diemunsch P.; Conseiller C.; Clyti N.; Mamet JP The French Ondansetron Study Group. 《British journal of anaesthesia》1997,79(3):322-326
We have studied 746 males and females undergoing general anaesthesia for
any type of surgical procedure in a double-blind, controlled, randomized
study. After experiencing at least one nausea and/or one emetic episode in
the 6 h after recovery from anaesthesia, patients received either
ondansetron 4 mg i.v. or metoclopramide 10 mg i.v. Patients were observed
for postoperative nausea and vomiting (PONV) for 24 h after drug
administration. Complete control of PONV was achieved more frequently in
the ondansetron-treated patients compared with the metoclopramide-treated
patients during the 24-h period (59% vs 41% (P < 0.001) and 44% vs 34%
(P = 0.006) for emetic episodes and nausea, respectively). Furthermore,
ondansetron was associated with greater patient satisfaction than
metoclopramide (P < 0.001) with 49% and 32% of patients, respectively,
very satisfied. The overall incidence of adverse events was similar in the
ondansetron (7%) and metoclopramide (8%) groups. Ondansetron was as well
tolerated and more effective than metoclopramide for all assessment
criteria in the treatment of established PONV.
相似文献
164.
165.
JP Ortonne† HC Korting‡ C Viguié-Vallanet§ C Larnier¶ E Savaluny¶ 《Journal of the European Academy of Dermatology and Venereology》2006,20(10):1307-1313
BACKGROUND: Tinea pedis is a common dermatophyte infection with frequent recurrences. Terbinafine (presently used as a 1-week topical treatment of tinea pedis) is now available in a novel topical solution (film-forming solution--FFS), developed to allow single application. OBJECTIVES: To demonstrate the efficacy and safety of terbinafine 1% FFS in a randomized, double-blind, placebo-controlled, phase III trial, and to determine relapse or re-infection rate of tinea pedis at 12 weeks. PATIENTS/METHODS: Fifty-four centres (27 in France; 27 in Germany) enrolled 273 evaluable patients (2 : 1 randomization). Patients applied terbinafine 1% FFS or placebo only once between, under and over the toes, soles and sides of both feet. Efficacy assessments included direct microscopy, mycological culture, and clinical signs and symptoms at baseline, and at weeks 1, 6 and 12 after the single drug application. RESULTS: Effective treatment (negative mycology plus absent/minimal symptoms) at week 6 in the terbinafine 1% FFS group was 63%; vehicle was 17% (P相似文献
166.
K Chardon V Bach F Telliez P Tourneux E B Elabbassi V Cardot C Gaultier J P Libert 《Clinical neurophysiology》2003,33(4):196-202
In neonates, it is often assumed that ventilatory control and heat stress interact. Thus the two factors have been implicated in various pathologies (apnoea, sudden infant death syndrome). However, little is known about the mechanisms of this interaction, and the influence of sleep is still debated. This study aimed at determining the influence of warm exposure on the decrease in ventilation during a hyperoxic test (HT), which is considered to be a measure of peripheral chemoreceptor activity. The test was performed in active (AS) and quiet sleep (QS) in 12 neonates exposed to thermoneutral or warm environments. The HT consisted of 30 s of inspired, 100% O(2). The ventilatory response was assessed in terms of a response time, defined as the time elapsing between HT onset and the first significant change in V(E). Our results show that, in both thermal conditions, the fall in V(E) was higher in AS than in QS. Warm exposure significantly enhanced the ventilatory response in AS (-27.5 +/- 8.7% vs. -38.3 +/- 8.8%, P < 0.01) but not in QS. A thermometabolic drive or inputs from thermoreceptors could be involved in the reinforcement of peripheral chemoreceptor activity in AS in warmer environments, which could contribute to an increasing risk of apnoea in neonates with altered chemoreceptor function. Since hypothalamic structures are involved in thermoregulatory, sleep processes and (probably) in respiratory control, it could well be the principal site where this interaction occurs. 相似文献
167.
HLA-DRB1*04 subtypes are associated with increased inflammatory activity in early rheumatoid arthritis 总被引:3,自引:2,他引:1
Seidl C; Koch U; Buhleier T; Frank R; Moller B; Markert E; Koller-Wagner G; Seifried E; Kaltwasser JP 《Rheumatology (Oxford, England)》1997,36(9):941-944
The sequence polymorphism of HLA-DRB1 molecules in 84 rheumatoid arthritis
(RA) patients with early RA has been analysed to evaluate whether
particular HLA-DR alleles influence disease progression in the early stage
of the disease. Clinical data were analysed by grouping the patients
according to disease-associated haplotype combinations
(DRB1*04,04/DRB1*04,01/DRB1*04,X/DRB1*01,X) in comparison to patients who
did not carry these haplotypes (DRB1*X,X). Our results indicate that
patients with early RA who are homozygous for DRB1*04 exhibit an elevated
inflammatory activity and an increase of joint affections. In addition, the
amino acid polymorphism (QR/KRAA) at position 70-74 seems to affect the
production of rheumatoid factors. These results support the role of
HLA-DRB1 alleles in the pathogenesis of RA and indicate that patients with
particular HLA-DRB1*04 haplotype combinations may require intensified
therapeutic interventions in the early stage of the disease to prevent
disease progression.
相似文献
168.
双波长一元线性回归分光光度法同时测定复方氨基比林注射液中三组分含量 总被引:3,自引:0,他引:3
本文依据一组含有不同比例待测和干扰组分的标准混合液的吸收值,采用一元线性回归方法,在选择最佳测定波长对的同时建立标准工作曲线方程,使其更符合实际作品测定时的情况,提高了结果的精度和可靠性,并使计算量和实验工作量得以降低。应用于复方氨基比林注射液中三组分氨基比林、安替比林和巴比妥的同时测定,其平均回收率分别为99.8%,100.4%和99.8%,变异系数分别为0.59,1.48和1.05,结果优于卡尔曼滤波法、偏最小二乘法和目标因子分析法。 相似文献
169.
Summary— The aim of the present study was the investigation of pretreatment effects with clonidine (0.06 mg/kg, intraperitoneal [ip]), lithium (1 mEq, ip) or quinine (0.5 mg/kg, ip) on the activities of various drugs acting on noradrenergic and/or serotonergic systems in the mouse tail suspension test. Drugs used in the present study included: the tricyclic antidepressants imipramine and dothiepin, the heterocyclic antidepressant trazodone, the 5-HT reuptake inhibitor (SSRI) fluoxetine, the atypical antidepressants mianserin and iprindole, the 5-HT1A receptor agonist ipsapirone, the 5-HT2A/2C receptor antagonist ritanserin, and the 5-HT3 receptor antagonist ondansetron. Clonidine, lithium and quinine differentially enhanced the effects of several psychotropic drugs administered at sub-active doses. The activity of iprindole (32 mg/kg, ip) was not potentiated by pretreatment with clonidine, lithium or quinine. Our results suggest that lithium exerted additive effects via postsynaptic 5-HT1A receptor activation, quinine via potassium ion channel blockade of 5-HT3 receptors, while clonidine did so primarily via action at 5-HT2 receptors. 相似文献
170.
PM Braillon AL Guibal P Pracros-Deffrenne A Serban JP Pracros P Chatelain 《Acta paediatrica (Oslo, Norway : 1992)》1998,87(9):924-929
Ninety five normal Caucasian subjects (51F, 44 M) aged from 2 to 25 y were measured at the hand and wrist level with a small DXA system (pDEXA™) in order to obtain the normal values of the bone mineral content (BMC), density (BMD) and projected area (A) of carpal (c) and metacarpal (m) bones. BMDc ranged from 0.065 ± 0.007 g/cm to 0.365 ± 0.035 g/cm in females and 0.425 ± 0.040 g/cm in males. It presented a sharp change of increase rate at 15.5 and 17 y of age in girls and boys, respectively. Ac presented the same kind of evolution as BMDc, but had a larger value dispersion. The second metacarpal bone had the highest BMCm value in 85% of females and 90% of males. The sum of BMCmi or Ami values (i = 1–5) and the projected mean density of the 5 metacarpal bones was well correlated with BMCc, Ac and BMDc, respectively ( r > 0.90). A volumetric mineral density, dmi, calculated for each of these bones, approximated to a cylinder, was correlated with age ( r > 0.85). 相似文献