高压静电疗法治疗失眠89例

0 引言 失眠症是神经内科常见病症之一,由多种疾病所致,用药物及其它内科治疗手段效果欠佳还可引起某些副作用. 我们采用高压静电疗法治疗失眠症,获得较好疗效.     

Molecular characterization of macbecin as an Hsp90 inhibitor

Macbecin compares favorably to geldanamycin as an Hsp90 inhibitor, being more soluble, stable, more potently inhibiting ATPase activity (IC50 = 2 microM) and binding with higher affinity (Kd = 0.24 microM). Structural studies reveal significant differences in their Hsp90 binding characteristics, and macbecin-induced tumor cell growth inhibition is accompanied by characteristic degradation of Hsp90 client proteins. Macbecin significantly reduced tumor growth rates (minimum T/C: 32%) in a DU145 murine xenograft. Macbecin thus represents an attractive lead for further optimization.     

Health inequalities in the Netherlands: a cross-sectional study of the role of Type D (distressed) personality

Background  

In the Netherlands, as in many European countries, inequalities in health exist between people with a high and a low socioeconomic status (SES). From the perspective of the 'indirect selection hypothesis', this study was designed to expand our understanding of the role of Type D personality as an explanation of health inequalities.     

1-环丙基-6,7-二氟-8-甲氧基-1,4-二氢-4-氧代喹啉羧酸乙酯精制方法的考察

目的：采用不同溶剂重结晶法对1－环丙基－6,7－二氟－8－甲氧基－1,4－二氢－4－氧代喹啉羧酸乙酯精制并对精制品进行质量分析,从而确定较理想的精制方法。方法：采用无水乙醇、甲醇、乙酸乙酯、丙酮作为重结晶溶剂,采用熔点、红外光谱、高效液相色谱法对精制品进行质量分析。结果：四种精制品的外观、熔点基本一致;IR光谱一致;纯度差异较大,丙酮精制品纯度为82．4％,其余三种均大于98％。结论：选用无水乙醇进行精制,产品纯度高。     

长春西汀在大鼠体内的药代动力学及生理处置

大鼠iv本品的时量曲线属二室开放模型。给大鼠iv本品5及10mg·kg^-1后,药物自血浆的清除呈线性动力学。该药给大鼠iv及ig后,体内分布广、消除迅速,原形药可进入脑组织。本品自大鼠尿、粪、胆汁的排出量均很少。     

甘草锌对顺铂毒性及抗癌效果的影响

本文观察了甘草锌对顺铂毒性及抗癌作用的影响。结果表明甘草锌对顺铂引起的肾脏、血液、生殖系统损害及致死毒性均有一定保护作用。经金属硫蛋白(MT)测定结果显示小鼠心、肝、肾组织中MT的含量均有明显增加,但其肿瘤组织中MT浓度较对照组无明显差别。经体内、外抑瘤实验表明甘草锌对顺铂的抗癌效果无明显影响。因此提示甘草锌可通过诱导MT降低顺铂毒性,有望作为抗癌药物的减毒剂应用于临床。     

Abnormal vaginal bleeding in women of reproductive age: a descriptive study of initial management in general practice

Background  

Abnormal vaginal bleeding (AVB) in women of reproductive age is a common reason for consulting a general practitioner. Nevertheless, how general practitioners (GPs) choose to initially manage AVB is largely unknown, as is the prevalence of underlying pathology of AVB in primary care.     

Oral health care patterns and the history of miscarriage

Objective: Oral infections can trigger the production of pro‐inflammatory mediators that may be risk factors for miscarriage. We investigated whether oral health care patterns that may promote or alleviate oral inflammation were associated with the history of miscarriage in 328 all‐Caucasian women. Materials and methods: Of 328 women in this cross‐sectional cohort, 74 had history of miscarriage (HMC). Medical, dental and sociodemographic data were collected through clinical examinations, medical record searches and structured questionnaires. Results: The multivariate regression analyses indicated that urgency‐based dental treatment demonstrated a significant association [odds ratio (OR) = 2.54; 95% confidence interval (CI): 1.21–5.37; P = 0.01] and preventive dental treatment demonstrated a marginally significant inverse association (OR = 0.53; CI: 0.26–1.06; P = 0.07) with HMC. Self‐rated poor oral health had a non‐significant positive association with HMC (OR 1.60; CI: 0.88–2.90). Conclusion: Our results provide sufficient evidence for hypothesis generation to test whether other precise measures of oral inflammation are associated with adverse birth outcomes.     

Distress or no distress,that's the question: A cutoff point for distress in a working population

Background  

The objective of the present study is to establish an optimal cutoff point for distress measured with the corresponding scale of the 4DSQ, using the prediction of sickness absence as a criterion. The cutoff point should result in a measure that can be used as a credible selection instrument for sickness absence in occupational health practice and in future studies on distress and mental disorders.     

The use of portfolios for assessment of the competence and performance of doctors in practice

BACKGROUND: The use of portfolios can potentially provide flexibility in the summative assessment of doctors in practice. An assessment system should reflect and reinforce the active and planned professional development goals of individual doctors. This paper discusses some of the issues involved in developing such a system. RESULTS: To provide a complete picture of an individual doctor's practice, we suggest that a portfolio should encompass: (1) evidence covering all three domains of patient care, personal development and context management; (2) evidence that the person continuously undertakes critical assessment of their own performance, identifies and prioritises areas requiring enhanced performance and takes action to improve them as appropriate; (3) evidence that has been generated by assessments that are acceptably reliable, and (4) evidence which, taken in its entirety, is sufficient, valid, current and authentic. We include a suggested outline of the components of such a portfolio and suggest some criteria to determine the effectiveness of learning cycles. Portfolio reliability and validity requires sufficient evidence on which to base a judgement combined with reliable processes. CONCLUSION: Carefully specified portfolios can contribute to a system that ensures all doctors take an active part in identifying and meeting their own learning needs. Such a system, if properly implemented, would have a greatly beneficial impact on continuous quality improvement for the profession in general.