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Marco Scarpa Duilio Pagano Cesare Ruffolo Anna Pozza Lino Polese Mauro Frego Davide F. D’Amico Imerio Angriman 《Journal of gastrointestinal surgery》2009,13(1):105-112
Background and Aims While colonic resection is standard practice in complicated colonic diverticular disease (DD), treatment of uncomplicated
diverticulitis is, as yet, unclear. The aim of the present study was to evaluate the long-term clinical outcome and quality
of life in DD patients undergoing colonic resection compared to those receiving medical treatment only.
Patients and Methods Seventy-one consecutive patients who were admitted to our surgical department with left iliac pain and endoscopical or radiological
diagnosis of DD were enrolled in this trial. Disease severity was assessed with Hinchey scale. Twenty-five of the patients
underwent colonic resection, while 46 were treated with medical therapy alone. After a median follow-up of 47 (3–102) months
from the time of their first hospital admission, the patients responded to the questions of the Cleveland Global Quality of
Life (CGQL) questionnaire and to a symptoms questionnaire during a telephone interview. Admittance and surgical procedures
for DD were also investigated, and surgery- and symptoms-free survival rates were calculated. Nonparametric tests and survival
analysis were used.
Results The CGQL total scores and symptom frequency rate were found to be similar in the two groups (resection vs nonresection). Only
current quality of health item was significantly worse in patients who had undergone colonic resection (p = 0.05). No difference was found in the rate and in the timing of surgical procedures and hospital admitting for DD in the
two groups. In particular, the nine patients classified as Hinchey 1 who underwent surgery reported the same quality of life,
symptoms frequency, operation, and hospital admitting rate as those who had been admitted with the same disease class but
who received medical treatment only.
Conclusions Our results indicate that there does not seem to be any long-term advantage to colonic resection which should be considered
only in patients presenting complicated DD.
Presented as a poster at the Digestive Disease Week, San Diego CA, USA May 19-24, 2008. 相似文献
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Fruhauf J Schaider H Massone C Kerl H Mullegger RR 《Mayo Clinic proceedings. Mayo Clinic》2008,83(4):502-504
Trigeminal trophic syndrome is a rare condition resulting from self-manipulation of the skin after a peripheral or central injury to the trigeminal system. The syndrome consists of a classic triad of anesthesia, paresthesias, and secondary persistent or recurrent facial ulcerations. The most common causes include destruction of the trigeminal ganglion, rhizotomy, and stroke. We describe a patient who developed the syndrome as a sequel to brainstem infarction and trigeminal neuropathy. Whereas a-lipoic acid and gabapentin were ineffective, a remarkable benefit was achieved by administering carbamazepine (200 mg 3 times a day), which influences both neuropathic and behavioral factors in this rare syndrome. Our experience with the presented case, together with the scarce information in the literature, indicates that carbamazepine should be the first treatment option for trigeminal trophic syndrome. 相似文献
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Franchini M Lippi G Veneri D Targher G Zaffanello M Guidi GC 《Clinica chimica acta; international journal of clinical chemistry》2008,387(1-2):1-8
Inherited platelet disorders are a rare, but probably underdiagnosed, cause of symptomatic bleeding. They are characterized by abnormalities of platelet number (inherited thrombocytopenias), function (inherited disorders of platelet function) or both. This review briefly discusses the inherited platelet disorders with respect to molecular defects, diagnostic evaluation and treatment strategies. 相似文献
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Ballarò B Florena AM Franco V Tegolo D Tripodo C Valenti C 《Medical image analysis》2008,12(6):703-712
This work describes an automatic method for discrimination in microphotographs between normal and pathological human megakaryocytes and between two kinds of disorders of these cells. A segmentation procedure has been developed, mainly based on mathematical morphology and wavelet transform, to isolate the cells. The features of each megakaryocyte (e.g. area, perimeter and tortuosity of the cell and its nucleus, and shape complexity via elliptic Fourier transform) are used by a regression tree procedure applied twice: the first time to find the set of normal megakaryocytes and the second to distinguish between the pathologies. The output of our classifier has been compared to the interpretation provided by the pathologists and the results show that 98.4% and 97.1% of normal and pathological cells, respectively, have testified an excellent classification. This study proposes a useful aid in supporting the specialist in the classification of megakaryocyte disorders. 相似文献
1000.
A growing body of evidence indicates that the clustering of metabolic and hemodynamic abnormalities characterizing the metabolic syndrome is associated with a prevalence of subclinical damage in a variety of organs, such as left ventricular hypertrophy, thickening or atherosclerotic plaques of carotid arteries, microalbuminuria and deranged renal function. This is clinically relevant since these markers of target organ damage are associated with an increased risk of cardiovascular fatal and nonfatal events. The contribution of the metabolic syndrome to target organ damage in hypertensives is presumably responsible for a substantial increase in cardiovascular fatal and nonfatal events. Thus, target organ damage should be routinely searched for in hypertensives with metabolic syndrome in order to define initial therapeutic strategies and to monitor treatment-induced protection. 相似文献