磁场对家兔急性实验性高血压的影响

目的 :探讨内关穴敷磁的降压效应。方法 :40只清醒家兔和 40只麻醉家兔 (其中 2 0只去减压神经 ) ,静脉注射去甲肾上腺素或苯肾上腺素引起急性实验性高血压 ,并于内关穴敷磁 (0 .1～ 0 .2T) ,记录血压、心率和敷磁前及 1h后的血液粘度的变化。结果 :敷磁 1h后各实验组平均动脉压 (MAP)显著下降 (P <0 .0 1)。麻醉和清醒家兔MAP降幅无差异 (P >0 .0 5 ) ,但显著高于去减压神经家兔MAP的降幅 (P <0 .0 1或 0 .0 5 ) ,各实验组全血比粘度显著下降 (P <0 .0 1或 0 .0 5 ) ,实验组与各自对照组心率敷磁前后无差异 (P >0 .0 5 )。结论 :磁场具有降压作用 ,但对心率无影响 ,其降压效应与减压神经的抑制和全血粘度的降低有关 ,与化学感受性升压反射无关     

Procidentia in the newborn

Complete uterine prolapse was noted shortly after birth in a female infant with a meningomyelocele at the level of the iliac crest with a palpable dimpled defect caudal to the primary lesion. The vagina and uterus were restored to their normal position with a rubber nipple placed into the vagina. The prolapse resolved on the sixth day of life after a repair of the meningomyelocele. Thus, conservative therapy with temporary support provides a satisfactory solution for newborn procidentia.     

环孢素A治疗难治性肾病综合征的临床观察

目的 :研究环孢素A(CsA)治疗原发性难治性肾病综合征的疗效及安全性。方法 :2 1例患者均行肾活检检查 ,其中系膜增殖性肾小球肾炎 (MsPGN) 13例 ,膜性肾病 (MN) 6例 ,膜增殖性肾小球肾炎 (MPGN) 2例。采用皮质激素和CsA联合治疗 ;CsA初始剂量 5mg·kg-1·d-1,3个月后适当减量 ,疗程 1年以上。强的松开始剂量 1mg·kg-1·d-1,8周后逐渐减量 ,疗程也在 1年以上。结果 :CsA联合皮质激素 ,使系膜增殖性肾小球肾炎和膜性肾病患者蛋白定量下降 ,血清白蛋白上升 (P<0 .0 1)。 13例系膜增殖性病变患者中 4例在第 4周起效 ,11例获完全缓解。 6例MN患者中 ,3例第 8周见效 ,4例获完全缓解 ,1例部分缓解 ,1例无效。膜增殖性肾炎患者 1例部分缓解 ,1例无效。治疗前后肾功能无变化。结论 :CsA是治疗难治性肾病综合征有效的免疫抑制剂 ,对于CsA的适应症、治疗时间及长期应用的安全性还需进一步研究     

Relative frequency of solitary melanocytic lesions of the oral mucosa

Background: Solitary pigmented lesions of melanocytic origin are uncommon in the oral mucosa. These lesions include the oral and labial melanotic macule, oral melanocytic nevus, oral melanoacanthoma, oral melanoma and atypical melanocytic proliferation. The purpose of the study was twofold: to report a large series of solitary melanocytic lesions from one source, and to determine the relative frequency of these lesions. Methods: The study was based on a systematic search of the files of the Pacific Oral and Maxillofacial Pathology Laboratory, University of the Pacific, San Francisco for solitary pigmented melanocytic lesions (benign and malignant) accessed during the years 1984–2002. Results: Of the 89 430 biopsies accessed during the 19‐year period, 773 (0.83%) cases of solitary pigmented melanocytic lesions in the oral mucosa were identified. Oral and labial melanotic macules were the most common melanocytic lesions comprising 86.1% of the entire group and 0.7% of the total number of accessed biopsies. The vermilion border and gingiva were the most common sites (31.1% and 31.0% respectively). Oral melanocytic nevi comprised 11.8% of the entire melanocytic group and 0.1% of the total number of biopsies. The most common site was the palate (44%). Intramucosal nevi were the most common (64%), followed by compound nevi (16.5%) and common blue nevi (16.5%). Junctional nevi were uncommon (3.0%). Oral melanoacanthoma comprised only 0.9% of the entire melanocytic group and 0.008% of the total number of biopsies. Oral melanoma and atypical melanocytic proliferation were the least common lesions each comprising 0.6% of the entire melanocytic group and 0.006% of the total number of biopsies. The most common site for oral melanoma was the palate (60%). Conclusion: The palate was the most common location for both melanocytic nevi and oral melanoma. Thus, all melanocytic lesions in the palate should be viewed with caution and biopsy is recommended to rule out melanoma. Further studies are required to elucidate the entity of oral atypical melanocytic proliferation.     

1600例住院病人死亡原因分析

[目的 ]探讨 160 0例住院病人的死亡原因及其分布特征 .[方法 ]收集 1995年 1月至 2 0 0 2年12月间 160 0例我院住院死亡病人资料 ,对死亡疾病构成比率、男女主要疾病死亡构成比率、汉族和朝鲜族主要疾病死亡构成比率及年龄构成比率进行统计 .[结果 ] 160 0例死亡病例的死亡原因中脑血管疾病占 2 4 9% ,恶性肿瘤占 2 3 4% ,消化系统疾病占 13 7% ,意外伤害和中毒占 10 3 % ,心血管疾病占9 2 % ;男性与女性主要疾病死亡分布不同 ,两者间有非常显者性差异 ;汉族与朝鲜族主要疾病死亡分布不同 ,两者间亦有非常显者性差异 ;年龄构成比中 61～ 70岁居首位 ,占 2 6 6% ,51～ 60岁占 18 0 % ,41～ 50岁占 16 8% ,71～ 80岁占 15 8% ,3 1～ 40岁占 10 8% .[结论 ]住院死亡的疾病构成因性别及民族不同 ,其分布不同     

腹膜透析患者腹透液中细胞因子水平的研究

目的　研究不卧床持续性腹膜透析 (CAPD)患者腹透液中转移生长因子 β1 (TGF β1 )水平及影响因素对腹膜小分子物质清除功能的影响。方法　测定CAPD患者血浆中和腹透液中TGF β1 、IL 6、TNF、CRP(C反应蛋白 )水平 ;同时统计CAPD患者腹透液葡萄糖含量、交换量、次数、留腹时间及腹膜炎次数 ;计算CAPD患者KpT V、Cpcr。结果　CAPD患者血浆中IL 6、TNF、CRP水平均明显高于正常健康人 ,P <0 .0 5～ 0 .0 1;透析第 12月 (KpT V +Cpcr) 2较第 3月下降超过 10 %的CAPD患者其腹透液中TGF β1、IL 6、TNF、CRP、葡萄糖浓度、腹膜炎次数均较对照组明显升高 ,P <0 .0 5～ 0 .0 1;腹透液中TGF β1 与IL 6、TNF、CRP、腹透液中葡萄糖浓度呈正相关 ,P <0 ..0 5～ 0 .0 1,与腹膜炎次数无关 ;腹透液中CRP与葡萄糖浓度、腹膜炎次数呈正相关 ,P <0 .0 5～ 0 .0 1,与腹膜交换量、次数、留腹时间无关。结论　CAPD患者体内确实存在慢性炎症状态 ,其炎症标志性因子CRP与腹透液葡萄糖浓度、腹膜炎次数有关 ,CAPD患者腹膜物质转运功能丧失与TGF β1 、IL 6、TNF、CRP升高有关。     

闭合复位经皮螺钉内固定治疗跖跗关节损伤

目的探讨应用闭合复位经皮螺钉内固定治疗跖跗关节损伤的临床疗效。方法自2003年1月～2005年6月应用闭合复位经皮螺钉内固定治疗跖跗关节损伤26例。按照Myerson分类:中间柱损伤13例,内侧、中间柱合并损伤7例,内侧、中间、外侧柱三柱损伤6例。结果本组切口均一期愈合,平均手术时间为40min(30～70min),切口长度平均为5mm;所有患者获平均11.4个月(6～17个月)随访,根据美国足踝骨科协会(AOFAS)评分平均为87分,患者术后平均5.3个月(3～11个月)恢复正常生活。结论闭合复位经皮螺钉内固定手术创伤小,软组织并发症低,能有效治疗跖跗关节复合体损伤;中间柱复位并沿Lisfranc韧带方向插入螺钉内固定是重建跖跗关节复合体稳定性的关键。