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991.
Viola Guardigni Valeria Cento Stefano Ianniruberto Lorenzo Badia Marianna Aragri Matteo Conti Carlo Federico Perno Pierluigi Viale Francesca Ceccherini-Silberstein Gabriella Verucchi 《Infection》2018,46(5):717-720
Direct-acting antivirals (DAAs) for the treatment of HCV have dramatically increased the rate of sustained virological response: patients not achieving sustained virological response represent a challenge and rates of late recurrent viremia are very low. We describe here the first case of a very late HCV relapse, following an atypical kinetics (characterized by a spontaneous but transient HCV clearance after an early virological relapse), in a HIV co-infected patient treated with DAAs. Optimal adherence to the therapy was well documented and a phylogenetic analysis ruled out a possible reinfection from a different HCV strain. In conclusion, our case underlines the importance of a long follow-up (>?48 weeks) after DAAs therapies in HCV–HIV co-infected patients who might benefit the most from a very rigorous virological surveillance. 相似文献
992.
993.
Adriaan Wilgenhof MD Carlo Zivelonghi MD Stefan Verheye MD PhD Paul Vermeersch MD PhD Benjamin Scott MD Carl Convens MD Leo Timmers MD PhD Geert Leenders MD PhD Jan Peter Van Kuijk MD PhD Pieter Stella MD PhD Pierfrancesco Agostoni MD PhD 《Catheterization and cardiovascular interventions》2021,97(7):E929-E935
994.
Giovanni A. Tommaselli Alessandro D’Afiero Costantino Di Carlo Carmen Formisano Annamaria Fabozzi Carmine Nappi 《Journal of minimally invasive gynecology》2013,20(2):198-204
ObjectiveTo compare the efficacy of the inside-out tension-free vaginal tape–obturator (TVT-O) device versus the single-incision TVT-Secur device 36 months after the procedure.MethodsA single-blind, randomized, parallel-group study on 154 patients with stress urinary incontinence (77 treated with TVT-O and 77 with the TVT-Secur hammock approach). The primary endpoint was the objective cure rate 36 months after the procedure evaluated with the challenge stress test. Secondary endpoints were subjective cure rate (evaluated with bladder diary, quality-of-life questionnaires, and patient-reported outcome tools) and intraoperative and postoperative complications. The primary endpoint was evaluated with a noninferiority study design.ResultsSixty-six patients in the TVT-O group and 64 in the TVT-Secur group concluded the study. Thirty-six months after the procedure, 57/66 patients (86.4%) in the TVT-O and 50/64 (78.1%) in the TVT-Secur groups were objectively cured (noninferiority unilateral u test: p < .05). No differences were observed in the subjective cure and complication rates.ConclusionsTVT-Secur seems not to be inferior to TVT-O in the surgical treatment of stress urinary incontinence and causes less postoperative pain. The possibility of severe blood loss cannot be ruled out when TVT-Secur is used. 相似文献
995.
996.
Alessandro Pecci Emanuele Panza Daniela De Rocco Nuria Pujol‐Moix Giorgia Girotto Luigi Podda Carmelo Paparo Valeria Bozzi Annalisa Pastore Carlo L. Balduini Marco Seri Anna Savoia 《European journal of haematology》2010,84(4):291-297
MYH9‐related disease (MYH9‐RD) is a rare autosomal dominant disorder caused by mutations in MYH9, the gene encoding the heavy chain of non‐muscle myosin IIA. All patients present congenital macrothrombocytopenia and inclusion bodies in neutrophils. Some of them can also develop sensorineural deafness, presenile cataract, and/or progressive nephropathy leading to end‐stage renal failure. We report four families, each with a novel mutation: two missense mutations, in exons 31 and 32, and two out of frame deletions in exon 40. They were associated with no bleeding diathesis, normal, or only slightly reduced platelet count and no extra‐hematological manifestations, confirming that alterations of the tail domain cause a mild form of MYH9‐RD with no clinically relevant defects. 相似文献
997.
998.
Antonia Radaelli Eleana Pozzi Sole Pacchioni Carlo Zanotto Carlo De Giuli Morghen 《Journal of translational medicine》2010,8(1):40
Background
Around half million new cases of cervical cancer arise each year, making the development of an effective therapeutic vaccine against HPV a high priority. As the E6 and E7 oncoproteins are expressed in all HPV-16 tumour cells, vaccines expressing these proteins might clear an already established tumour and support the treatment of HPV-related precancerous lesions. 相似文献999.
Waldemar F. Carlo MD E. Dean McKenzie MD Timothy C. Slesnick MD 《Congenital heart disease》2011,6(3):228-233
Objective. A dilated aortic root is a common finding in children and adults with some forms of congenital heart defects. No data exist on root dilation in truncus arteriosus. We sought to delineate root dimensions across a population of patients with truncus arteriosus. Design. We performed a single‐center retrospective review of all patients with truncus arteriosus. Demographic information, clinical history, and most recent echocardiographic data were evaluated. Results. We identified 76 patients whose most recent study was at a median age of 5.4 years (range 0–32.7 years). Mean truncal root z‐score was 5.1 ± 2.3. All but three patients had truncal root z‐scores greater than or equal to 2. Truncal root z‐scores remained stable with increasing body surface area and age. There were no cases of dissection or rupture. Six patients underwent truncal root surgery, typically for indications of root dilation with significant truncal valve insufficiency and left ventricular dilation. Conclusions. In conclusion, mean truncal root z‐score was 5, and all but three patients had truncal root z‐scores greater than or equal to 2. Although repeat surgical intervention was rare and major complications related to root dilation did not occur in our cohort, further studies with longitudinal follow‐up into adulthood are needed. 相似文献
1000.