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91.
C?Shawn?Tracy Guilherme?Coelho?Dantas Ross?EG?UpshurEmail author 《BMC medical informatics and decision making》2004,4(1):13
Background
Concerns regarding the privacy of health information are escalating owing both to the growing use of information technology to store and exchange data and to the increasing demand on the part of patients to control the use of their medical records. The objective of this study was to evaluate the Health Care Information Directive (HCID), a recently-developed patient decision aid that aims to delineate the level of health information an individual is willing to share. 相似文献92.
A randomized controlled trial of three low-dose gonadotrophin protocols for unexplained infertility 总被引:1,自引:4,他引:1
This randomized controlled trial assessed which of three low-intensity
ovulation induction protocols was associated with the highest rate of cycle
completion among infertile women undergoing intrauterine insemination (IUI)
with their husband's spermatozoa. Sixty-three women aged < or = 42 years
with normospermic partners participated in the study. The primary diagnosis
of infertility was unexplained in 89% of subjects, endometriosis in 6% and
tubal factor in 5%. Women were assigned to three groups according to
recombinant FSH dosage: group A received two ampoules (75 IU FSH per
ampoule) on cycle day 4, and one ampoule on days 6 and 8 (total four
ampoules); group B received two ampoules on days 4, 6 and 8 (total six
ampoules); group C received two ampoules on days 4, 6, 8 and 10 (total
eight ampoules). Daily ultrasound investigations began on cycle day 9-12
and human chorionic gonadotrophin (HCG) 5000 IU was administered when one
or two follicles > or = 18 mm were seen. IUI was scheduled for the next
day. HCG was given and/or ovulation shown to have occurred in 88 of 109
cycles attempted (81%) with no differences among the three dose groups. Two
singleton pregnancies occurred (2.3% per ovulatory cycle and 1.8% per cycle
start). There were no significant differences among the three regimes in
terms of cycle parameters, suggesting that an individualized and more
intensive approach to ovarian stimulation is necessary for many women with
unexplained infertility.
相似文献
93.
The effectiveness of ovulation induction and intrauterine insemination in the treatment of persistent infertility: a meta-analysis 总被引:6,自引:19,他引:6
A systematic review was conducted to evaluate the effectiveness of
intrauterine insemination (IUI) with or without ovarian stimulation using
gonadotrophin in the treatment of persistent infertility. Relevant
randomized controlled trials were identified by a diverse strategy
including a hand search of 43 core journals from 1966 to the present. Two
approaches to meta-analysis were used to summarize data. First, using a
standard Mantel-Haenszel approach, eight trials comparing FSH/IUI with
FSH/timed intercourse for unexplained infertility were combined. The common
odds ratio for pregnancy was 2.37 [95% confidence interval (CI), 1.43,
3.90], suggesting a significant improvement with IUI following ovulation
induction in this patient group. Although the data were statistically
homogeneous, clinically important heterogeneity was present. Second, across
all diagnostic groups, the independent effects of treatment with follicle
stimulating hormone (FSH), clomiphene citrate, IUI, as well as the
diagnoses of male factor and endometriosis were assessed using stepwise
logistic regression. Based on 5214 cycles reported in 22 trials, the odds
ratio for pregnancy associated with FSH use was 2.35 (95% CI, 1.87, 2.94)
for IUI, 2.82 (95% CI, 2.18, 3.66) for male factor, 0.48 (95% CI, 0.37,
0.61), and for endometriosis 0.45 (95% CI, 0.27, 0.76). This summary of the
best available evidence may prove useful in counselling couples who are
considering FSH and/or IUI therapy.
相似文献
94.
Background
Stroke patients' care in hospital tends to be poorly organised, with poor communication and a lack of information being frequent sources of complaint. The purpose of this study was to evaluate whether a patient-held record (PHR) would result in greater patient satisfaction and better care planning for stroke patients. 相似文献95.
C Tassorelli S Bragg JH Krege EG Doty PA Ardayfio D Ruff SA Dowsett T Schwedt 《The journal of headache and pain》2021,22(1)
BackgroundLasmiditan (LTN) is a selective 5-HT1F receptor agonist for the acute treatment of migraine in adults. We present detailed safety findings from the placebo-controlled, double-blind Phase 3 study, of LTN treatment across 4 attacks (CENTURION).MethodsPatients were randomized 1:1:1 to LTN 200 mg (LTN200), LTN100, or a control group that received placebo for 3 attacks and LTN50 for either the 3rd or 4th attack (1:1). Safety analyses were conducted for patients who took ≥1 dose of study drug and, in some cases, those who took all 4 doses.ResultsOverall, 1471 patients treated 4494 attacks. The incidences of treatment-emergent serious adverse events (SAEs) were - placebo, n=2 (0.4 %); LTN100, n=1 (0.2 %); LTN200, n=2 (0.4 %); no specific treatment-emergent SAE was reported in more than one patient. The most common treatment emergent adverse events (TEAEs) with lasmiditan were dizziness, paresthesia, fatigue, nausea, vertigo, and somnolence; the vast majority were mild or moderate in severity. The incidences of these TEAEs were highest during the first attack and decreased during subsequent attacks. For patients who experienced a common TEAE with the first attack, less than 45 % experienced the same event in subsequent attacks. Patients who did not experience an event in the 1st attack infrequently experienced the same event in subsequent attacks.The time of onset of the common TEAE ranged from ~40 min to 1 h (dependent upon TEAE) and, for individual TEAE, the onset was similar across attacks. Duration was dependent upon TEAE and attack. It was shortest for paresthesia (< 2 h for all attacks); it ranged from 1.8 to 5.5 h for other common TEAEs and was generally similar across attacks.Serotonin syndrome was reported for 2 patients post LTN dosing; there were no meaningful differences across treatment groups in suicidality; there was no evidence of an increase in motor vehicle accidents.ConclusionIn this blinded, controlled, multiple-attack study, LTN was associated with generally mild or moderate CNS-related TEAEs of short duration. TEAEs tended to decrease in frequency across the 4 attacks.Trial registration Supplementary InformationThe online version contains supplementary material available at 10.1186/s10194-021-01343-2. NCT03670810相似文献
96.
Esophageal motility: assessment with synchronous video tape fluoroscopy and manometry 总被引:1,自引:0,他引:1
Synchronous video tape fluoroscopy and manometry of the esophagus was performed in 11 subjects (seven men and four women; mean age, 49 years). Four had normal and seven had abnormal esophageal motility (diffuse esophageal spasm, n = 4; nonspecific esophageal motility disorder, n = 3) that was shown by previous manometry. A digital timer appeared on the video tape recording and marked the manometric tracing synchronously. Alternate 5-mL and 10-mL barium boluses were recorded for a total of 10 swallows per patient. Video tape examinations were reviewed prospectively, and the status of primary peristalsis and presence and severity of tertiary activity were noted. A total of 98 swallows (58 normal, 40 abnormal) were correlated, and a 96% agreement was found in assessing primary peristalsis. Overall results of fluoroscopic examinations of each subject during all swallows showed complete agreement with those of manometry; segregating the swallows into groups of five showed 92% concordance. Severe tertiary activity was invariably seen with abnormal primary peristalsis at fluoroscopy. 相似文献
97.
98.
Miranda EG Armstrong Elizabeth A Spencer Benjamin J Cairns Emily Banks Kirstin Pirie Jane Green F Lucy Wright Gillian K Reeves Valerie Beral for the Million Women Study Collaborators 《Journal of bone and mineral research》2011,26(6):1330-1338
Hip fracture risk is known to increase with physical inactivity and decrease with obesity, but there is little information on their combined effects. We report on the separate and combined effects of body mass index (BMI) and physical activity on hospital admissions for hip fracture among postmenopausal women in a large prospective UK study. Baseline information on body size, physical activity, and other relevant factors was collected in 1996–2001, and participants were followed for incident hip fractures by record linkage to National Health Service (NHS) hospital admission data. Cox regression was used to calculate adjusted relative risks of hip fracture. Among 925,345 postmenopausal women followed for an average of 6.2 years, 2582 were admitted to hospital with an incident hip fracture. Hip fracture risk increased with decreasing BMI: Compared with obese women (BMI of 30+ kg/m2), relative risks were 1.71 [95% confidence interval (CI) 1.47–1.97)] for BMI of 25.0 to 29.9 kg/m2 and 2.55 (95% CI 2.22–2.94) for BMI of 20.0 to 24.9 kg/m2. The increase in fracture risk per unit decrease in BMI was significantly greater among lean women than among overweight women (p < .001). For women in every category of BMI, physical inactivity was associated with an increased risk of hip fracture. There was no significant interaction between the relative effects of BMI and physical activity. For women who reported that they took any exercise versus no exercise, the adjusted relative risk of hip fracture was 0.68 (95% CI 0.62–0.75), with similar results for strenuous exercise. In this large cohort of postmenopausal women, BMI and physical activity had independent effects on hip fracture risk. © 2011 American Society for Bone and Mineral Research. 相似文献
99.
Background
Scientists engaged in global health research are increasingly faced with barriers to access and use of human tissues from the developing world communities where much of their research is targeted. In part, the problem can be traced to distrust of researchers from affluent countries, given the history of 'scientific-imperialism' and 'biocolonialism' reflected in past well publicized cases of exploitation of research participants from low to middle income countries. 相似文献100.