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SAMIR BASU M.D. CORRADO P. MARINI M.D. MATTHEW S. COONS M.D. THOMAS T. WOLOSZYN M.D. THIERRY A. FOLLIGUET M.D. F. GREGORY BAUMANN Ph. D. ISRAEL J. JACOBOWITZ M.D. 《Journal of cardiac surgery》1991,6(2):286-293
A bstract This study was designed to determine the feasibility of anastomosing the internal mammary artery (IMA) and coronary artery with a carbon dioxide laser in a canine model. Twenty-two mongrel dogs were randomly assigned to two groups: group I (n = 11) underwent laser-assisted vascular anastomosis (LAVA) of the left IMA to the left anterior descending (LAD) coronary artery, whereas in group II (n = 11) the anastomosis was done with the conventional technique (handsewn). Laser methodology was used to micro-weld vessels utilizing a power of 200 mW with a spot size of 500 μ, producing an effective power density of 102 W/cm2 and energy fluence of 9, 172 joules/cm2 in a continuous mode at a distance of 2 cm. The short-term patency rate, measured at 2 hours after completion of the anastomosis, was 100% in both groups. The time required to perform the LAVA in group I was significantly shorter than group II (6.27 ± 0.47 vs 11.6 ± 0.67 min, p < 0.05). The mean anastomotic bursting pressure in group I was significantly lower compared to group II (348 ± 8 vs 402 ± 9 mmHg, p < 0.05). Histologic evaluation of all vessels showed moderate thermal injury of the adventitia and media in the laser group. Scanning electron microscopy exhibited a smooth anastomotic area in group I, whereas endothelial and perianastomotic changes with multiple needle craters occurred in group II (conventional anastomosis). Based on the results of this study, we conclude that a low powered CO2 laser can be used to safely perform an IMA to LAD artery anastomosis, thus providing an alternative to conventional techniques because of its rapidity and minimization of anastomotic changes. 相似文献
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MICHELE BERTONI FILIPPO OLIVERI MARTA MANGHETTI ELENA BOCCOLINI MARIA GRAZIA BELLOMINI CORRADO BLANDIZZI FERRUCCIO BONINO MARIO DEL TACCA 《Pharmacological research》2002,46(6):525-531
The present study was performed in order to evaluate: (1) the influence of a bicarbonate-alkaline mineral water (Uliveto) on digestive symptoms in patients with functional dyspepsia; (2) the effects of Uliveto on preclinical models of gastric functions. Selected patients complained of dyspeptic symptoms in the absence of digestive lesions or Helicobacter pylori infection within the previous 3 months. They were treated with Uliveto water (1.5 l day(-1)) for 30 days. Frequency and severity of symptoms were assessed at baseline and day 30 by a score system. Preclinical experiments were carried out on rats, allowed to drink Uliveto or oligomineral water for 30 days. Animals then underwent pylorus ligation to evaluate gastric secretion of acid, pepsinogen, and mucus. In separate experiments, gastric emptying was assessed. Crenotherapy was associated with a relief of epigastric pain, retrosternal pyrosis, postprandial fullness and gastric distention. At preclinical level, Uliveto water increased acid and pepsinogen secretions as well as gastric emptying, without changes in bound mucus. The enhancing actions of Uliveto on gastric secretions and emptying were prevented by L-365,260, an antagonist of gastrin/CCK-2 receptors. These findings indicate that a regular intake of Uliveto favors an improvement of dyspeptic symptoms. The preclinical study suggests that the clinical actions of Uliveto water depend mainly on its ability to enhance gastric motor and secretory functions. 相似文献
55.
ANDREA ONETTI MUDA MAURO PARADISI CORRADO ANGELO PIETRO PUDDU TULLIO FARAGGIANA 《The Journal of pathology》1996,179(4):427-431
Absent or defective collagen VII at the dermo-epidermal junction is the hallmark of dystrophic recessive epidermolysis bullosa. Little is known of the alterations of other collagenous and non-collagenous components of the basement membrane; it is likely that their assembly may be disturbed by the lack of collagen VII molecules. The spatial relationship of collagen IV and laminin has been studied, both in bullous and in non-bullous areas. Skin biopsies from five patients affected by severe dystrophic recessive epidermolysis bullosa were rapidly frozen and freeze-dried. Collagen IV and laminin were labelled with specific monoclonal antibodies and FITC- or TRITC-conjugated secondary antibodies. Sections were observed with conventional light/fluorescence microscopy and with confocal laser scanning microscopy. Collagen IV and laminin were not co-localized: the former displayed a split image, being present at the floor and the roof of the blister, while the latter was confined to the roof. Confocal microscopy also allowed three-dimensional (3D) reconstruction of the dermo-epidermal junction from a series of optical sections, with viewing of the reconstructed specimen from a sequence of angles. By this procedure, laminin exhibits an irregular, coarsely granular distribution, both in affected and in apparently non-affected areas, while collagen IV appears as a homogeneous sheet. These results show that freeze-drying is the technique of choice for high-resolution immunofluorescence of skin samples and suggest that in dystrophic recessive epidermolysis bullosa, a complex disruption of the extracellular matrix assembly exists even before blister formation, probably due to the lack of collagen VII. 相似文献
56.
FEDERICO MIGLIORE M.D. Ph.D. ALESSANDRO ZORZI M.D. EMANUELE BERTAGLIA M.D. LOIRA LEONI M.D. Ph.D. MARIACHIARA SICILIANO M.D. MANUEL De LAZZARI M.D. BARBARA IGNATIUK M.D. MARTA VERONESE M.D. ROBERTO VERLATO M.D. GIUSEPPE TARANTINI M.D. Ph.D. SABINO ILICETO M.D. DOMENICO CORRADO M.D. Ph.D. 《Pacing and clinical electrophysiology : PACE》2014,37(12):1602-1609
57.
Hybrid Minimally Invasive Approach for Transvenous Lead Extraction: A Feasible Technique in High‐Risk Patients
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LUCA BONTEMPI M.D. FRANCESCA VASSANELLI M.D. MANUEL CERINI M.D. GIANLUIGI BISLERI M.D. ALBERTO REPOSSINI M.D. LAURA GIROLETTI M.D. LORENZA INAMA M.D. FRANCESCA SALGHETTI M.D. DARIA LIBERTO M.D. DANIELE GIACOPELLI M.Sc. ABDALLAH RAWEH M.D. CLAUDIO MUNERETTO M.D. ANTONIO CURNIS M.D. 《Journal of cardiovascular electrophysiology》2017,28(4):466-473
58.
Association between Beta1‐Adrenergic Receptor Polymorphism and Risk of ICD Shock in Heart Failure Patients
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59.
Miniaturized Implantable Loop Recorder in Small Patients: An Effective Approach to the Evaluation of Subjects at Risk of Sudden Death
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SILVIA PLACIDI M.D. FABRIZIO DRAGO M.D. MADDALENA MILIONI M.D. LETIZIA VERTICELLI C.C.P. ILARIA TAMBURRI C.C.P. MASSIMO STEFANO SILVETTI M.D. CORRADO DI MAMBRO M.D. DANIELA RIGHI M.D. FABRIZIO GIMIGLIANO M.D. MARIO SALVATORE RUSSO M.D. Ph.D. ROSALINDA PALMIERI M.D. ROMOLO REMOLI M.D. LORENZO MARIA SANTUCCI M.D. Ph.D. ALBERTO EUGENIO TOZZI M.D. 《Pacing and clinical electrophysiology : PACE》2016,39(7):669-674
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SISTO PERDONÀ RICCARDO AUTORINO LUIGI GALLO MARCO DE SIO LUIGI MARRA LUIGI CLAUDIO CORRADO CARACÒ RENATO FRANCO FLAVIO FAZZIOLI ANTONIO GALLO 《International journal of urology》2005,12(4):401-404
Solitary metastases to the small bones and/or to the soft tissue of the hands and feet (acrometastases) are rare. We report a case of renal cell carcinoma (RCC) with big toe metastasis revealed before the primary tumor became apparent. The best treatment for a single metastasis is always surgical excision, regardless of the lesion being synchronous or metachronous. The biological behavior of metastatic RCC is unpredictable and only early diagnosis and treatment may favorably affect patient survival. Thus, metastatic RCC should be included in the differential diagnosis of all enlarging cutaneous nodules, wherever they develop. 相似文献