全文获取类型
收费全文 | 14363篇 |
免费 | 868篇 |
国内免费 | 258篇 |
专业分类
耳鼻咽喉 | 287篇 |
儿科学 | 96篇 |
妇产科学 | 124篇 |
基础医学 | 2564篇 |
口腔科学 | 219篇 |
临床医学 | 1273篇 |
内科学 | 3148篇 |
皮肤病学 | 514篇 |
神经病学 | 1197篇 |
特种医学 | 978篇 |
外科学 | 1588篇 |
综合类 | 75篇 |
现状与发展 | 1篇 |
预防医学 | 482篇 |
眼科学 | 210篇 |
药学 | 1414篇 |
中国医学 | 235篇 |
肿瘤学 | 1084篇 |
出版年
2024年 | 8篇 |
2023年 | 106篇 |
2022年 | 388篇 |
2021年 | 634篇 |
2020年 | 283篇 |
2019年 | 389篇 |
2018年 | 468篇 |
2017年 | 353篇 |
2016年 | 520篇 |
2015年 | 720篇 |
2014年 | 890篇 |
2013年 | 963篇 |
2012年 | 1467篇 |
2011年 | 1377篇 |
2010年 | 784篇 |
2009年 | 656篇 |
2008年 | 842篇 |
2007年 | 840篇 |
2006年 | 672篇 |
2005年 | 653篇 |
2004年 | 497篇 |
2003年 | 443篇 |
2002年 | 397篇 |
2001年 | 198篇 |
2000年 | 197篇 |
1999年 | 153篇 |
1998年 | 75篇 |
1997年 | 66篇 |
1996年 | 36篇 |
1995年 | 30篇 |
1994年 | 37篇 |
1993年 | 25篇 |
1992年 | 41篇 |
1991年 | 29篇 |
1990年 | 40篇 |
1989年 | 32篇 |
1988年 | 30篇 |
1987年 | 27篇 |
1986年 | 20篇 |
1985年 | 28篇 |
1984年 | 12篇 |
1983年 | 13篇 |
1981年 | 8篇 |
1980年 | 4篇 |
1979年 | 9篇 |
1978年 | 3篇 |
1977年 | 3篇 |
1976年 | 4篇 |
1974年 | 3篇 |
1973年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
31.
32.
Jang AS Choi IS Lee S Nam HS Kweon SS Son MH Lee JH Park SW Kim DJ Uh ST Kim YH Park CS 《Journal of Korean medical science》2004,19(2):214-217
Passive smoking is a major cause of respiratory morbidity, and is associated with increased bronchial responsiveness in children. To evaluate the effect of smoking by a parent on asthma symptoms, atopy, and airway hyperresponsiveness (AHR), we conducted a cross-sectional survey of 503 schoolchildren that involved questionnaires, spirometry, allergy testing, and a bronchial challenge test. If the PC20 methacholine was less than 16 mg/mL, the subject was considered to have AHR. The prevalence of a parent who smoked was 68.7%. The prevalence of AHR was 45.0%. The sensitization rate to common inhalant allergens was 32.6%. Nasal symptoms such as rhinorrhea, sneezing, nasal itching, and nasal obstruction were present in 42.7%. Asthma symptoms such as cough and wheezing were present in 55.4%. The asthma symptoms were significantly more prevalent in children who had a parent who smoked than in those whose parents did not. The nasal symptoms, atopy, and AHR did not differ according to whether a parent smoked. In a multiple logistic regression model, the asthma symptoms and atopy were independently associated with AHR, when adjusted for confounding variables. Passive smoking contributed to asthma symptoms in schoolchildren and was not an independent risk factor of airway hyperresponsiveness in an epidemiological survey. 相似文献
33.
Jang SH Seol JY Kim CH Yoo CG Kim YW Han SK Shim YS Lee CT 《International journal of molecular medicine》2004,13(1):181-186
TRAIL is a cytokine that can induce tumor-specific apoptosis through its specific death receptors (DR4 and DR5) and p53 has been proven to increase the expression of death receptors. To examine their interaction in tumor suppression, p53 and TRAIL genes were inserted in recombinant adenovirus vectors and transferred simultaneously into non-small cell lung cancer cell lines (NCI-H157, NCI-H358, NCI-H460 and A549). Western blot assay demonstrated production of TRAIL protein in NCI-H157 and A549 cell lines. Increased expressions of DR4 and DR5 of NCI-H157 and DR4 of A549 after p53 overexpression were confirmed by flow cytometry. p53 or TRAIL gene transfer increased sub-G1 fraction in cell cycle analysis and inhibited the tumor growth dose-dependently and the degree was potentiated by co-transfer. But isobologram analysis indicated an additive effect. Together, these data indicate that p53 and TRAIL interact additively on tumor apoptosis despite theoretical synergism. 相似文献
34.
35.
Damiani AM Matsumura T Jang HK Izumiya Y Mikami T Takahashi E 《Archives of virology》2000,145(7):1489-1496
Summary. In order to identify the products of the equine herpesvirus type 4 (EHV-4) gI and gE genes, we have constructed recombinant
vaccinia viruses containing the putative gI or gE genes. These recombinant viruses synthesized EHV-4 gI and gE with apparent
molecular masses of 75 and 80 kDa, respectively. Antibodies raised against both recombinant viruses detected a 75 kDa gI and
a 95 kDa gE in EHV-4-infected cells. The results also suggest that the EHV-4 gI and gE would form a complex like in other
herpesviruses.
Received October 29, 1999 Accepted January 21, 2000 相似文献
36.
37.
Various inhibitors of cyclooxygenase are known to mediate cancer chemopreventive effects. We currently describe two in vitro assay systems for measuring cyclooxygenase activity. These assays can be used in combination and thereby provide a rapid, reliable, and economical approach that is applicable for large-scale evaluation of test samples. This approach employs peroxidase co-substrate oxidation and oxygen consumption assays. The former system, adapted to a 96-well plate format, detects inhibitors that function as a radical scavengers or interact with the enzyme directly. The latter system specifically monitors cyclooxygenase inhibitors that interact with the enzyme itself. Thus, the peroxidase co-substrate oxidation assay serves as a pre-screening method, whereas the oxygen consumption assay is used subsequently to investigate the mode of action mediated by samples which test positive. 相似文献
38.
Jang WJ Kim JH Choi YJ Jung KD Kim YG Lee SH Choi MS Kim IS Walker DH Park KH 《Journal of clinical microbiology》2004,42(5):2310-2313
To investigate the prevalence of spotted fever group rickettsioses in Korea, a serosurvey of Japanese spotted fever rickettsiosis in patients with acute febrile illness was conducted with an indirect immunofluorescence assay. Overall, 19.88% of the patients were found to have polyvalent antibody against Rickettsia japonica. This study is the first documentation of spotted fever group rickettsiosis in Korea. 相似文献
39.
The modifying potential of capsaicin (CAP) on lesion development was examined in a rat multiorgan carcinogenesis model. Groups 1 and 2 were treated sequentially with diethylnitrosamine (DEN) (100 mg/kg, ip, single dose at commencement), N-methylnitrosourea (MNU) (20 mg/kg, ip, 4 doses at days 2, 5, 8, and 11), and N,N-dibutylnitrosamine (DBN) (0.05% in drinking water during weeks 3 and 4). Group 3 received vehicles without carcinogens during the initiation period. Group 4 served as the untreated control. After this initiating procedure, Groups 2 and 3 were administered a diet containing 0.01% CAP. All surviving animals were killed 20 weeks after the beginning of the experiment and the target organs examined histopathologically. The induction of GST-P+ hepatic foci in rats treated with carcinogens was significantly inhibited by treatment with CAP. CAP treatment significantly decreased the incidence of adenoma of the lung but increased the incidence of papillary or nodular (PN) hyperplasia of the urinary bladder. The tumor incidence of other organs, such as the kidney and thyroid, was not significantly different from the corresponding controls. These results demonstrated that concurrent treatment with CAP not only can inhibit carcinogenesis but can also enhance it depending on the organ. Thus, this wide-spectrum initiation model could be used to confirm organ-specific modification potential and, in addition, demonstrate different modifying effects of CAP on liver, lung, and bladder carcinogenesis. 相似文献
40.
Clinical prognostic values of vascular endothelial growth factor, microvessel density,and p53 expression in esophageal carcinomas 总被引:6,自引:0,他引:6
Ahn MJ Jang SJ Park YW Choi JH Oh HS Lee CB Paik HK Park CK 《Journal of Korean medical science》2002,17(2):201-207
Vascular endothelial growth factor (VEGF) is known to play a key role in tumor angiogenesis. The tumor-suppressor gene p53 has been thought to regulate VEGF. We investigated the effect of VEGF on esophageal carcinoma and the correlation between VEGF and p53. Tissue samples were taken from 81 patients with esophageal carcinoma after surgery. VEGF and p53 expressions were examined by immunohistochemical staining. Microvessels in the tumor stained for CD34 antigen were also counted. VEGF and p53 expressions were observed in 51.3% (41/80) and 51.9% (41/79), respectively. The microvessel density was 70.9+/-6.7 (mean+/-SE) in VEGF-positive group and 68.7+/-5.1 in VEGF-negative group. However, no correlation was noted between VEGF and p53 expression. Whereas the tumor size, nodal status, depth of invasions, and tumor stage were associated with poor overall survival, VEGF expression or p53 expression was not. These results indicate that VEGF and p53 are highly expressed in esophageal carcinomas. Since the VEGF expression is not correlated with the p53 expression, microvessel density or clinicopathological findings, further studies with other angiogenic molecules are needed to determine the role in esophageal carcinomas. 相似文献