全文获取类型
收费全文 | 808篇 |
免费 | 68篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 26篇 |
妇产科学 | 4篇 |
基础医学 | 90篇 |
口腔科学 | 17篇 |
临床医学 | 151篇 |
内科学 | 144篇 |
皮肤病学 | 15篇 |
神经病学 | 19篇 |
特种医学 | 119篇 |
外科学 | 133篇 |
综合类 | 51篇 |
预防医学 | 54篇 |
眼科学 | 4篇 |
药学 | 35篇 |
1篇 | |
中国医学 | 2篇 |
肿瘤学 | 21篇 |
出版年
2022年 | 2篇 |
2021年 | 10篇 |
2020年 | 4篇 |
2019年 | 3篇 |
2018年 | 5篇 |
2017年 | 8篇 |
2016年 | 3篇 |
2015年 | 41篇 |
2014年 | 46篇 |
2013年 | 42篇 |
2012年 | 27篇 |
2011年 | 49篇 |
2010年 | 32篇 |
2009年 | 32篇 |
2008年 | 30篇 |
2007年 | 40篇 |
2006年 | 38篇 |
2005年 | 26篇 |
2004年 | 24篇 |
2003年 | 14篇 |
2002年 | 23篇 |
2001年 | 18篇 |
2000年 | 18篇 |
1999年 | 21篇 |
1998年 | 19篇 |
1997年 | 24篇 |
1996年 | 23篇 |
1995年 | 24篇 |
1994年 | 27篇 |
1993年 | 14篇 |
1992年 | 13篇 |
1991年 | 7篇 |
1990年 | 15篇 |
1989年 | 20篇 |
1988年 | 17篇 |
1987年 | 13篇 |
1986年 | 17篇 |
1985年 | 28篇 |
1984年 | 11篇 |
1983年 | 8篇 |
1982年 | 4篇 |
1981年 | 16篇 |
1980年 | 9篇 |
1979年 | 2篇 |
1978年 | 6篇 |
1977年 | 8篇 |
1976年 | 4篇 |
1969年 | 1篇 |
1957年 | 1篇 |
排序方式: 共有887条查询结果,搜索用时 15 毫秒
61.
S Amarri M Harding WA Coward TJ Evans LT Weaver 《Archives of disease in childhood》1997,76(4):349-351
Children with cystic fibrosis have variable degrees of exocrine pancreatic insufficiency which, if untreated, is the main cause of fat malabsorption. The impact of pancreatic enzyme supplementation on fat digestion was measured in 41 children with cystic fibrosis, 11 healthy controls, and five children with mucosal diseases by a non-invasive test of intraluminal lipolysis using 13carbon (13C) labelled mixed triglyceride (1,3-distearyl, 2[13C] octanoyl glycerol). The children with cystic fibrosis without pancreatic supplements had a median (range) 13C cumulative percentage dose recovered over six hours (cPDR) of 3.1% (0-31.7), the controls 31.0% (21.8-41.1), and the subjects with mucosal disease 27.8% (19.7-32.5). In 23 subjects with cystic fibrosis the usual dose of pancreatic enzyme supplements increased the cPDR to a median of 23.9% (0-45.6), and twice the usual dose of enteric coated microspheres increased the cPDR to 31.1% (11.1-47.8). There was no significant difference between the median cPDR of normal controls and children with mucosal disease, but there was a highly significant difference between these groups and children with untreated cystic fibrosis. Thirteen children with cystic fibrosis had no 13C recovery in their breath without enzymes and 10 showed marked increases with regular enzymes. In eight children doubling the dose of enzymes caused no or minimal improvement. The mixed triglyceride breath test offers a simple, non-invasive way of assessing the need for pancreatic enzyme supplementation in children with cystic fibrosis and could be used to optimise treatment. 相似文献
62.
63.
Interferon beta 1, an intermediate in the tumor necrosis factor alpha-induced increased MHC class I expression and an autocrine regulator of the constitutive MHC class I expression 总被引:2,自引:0,他引:2 下载免费PDF全文
J F Leeuwenberg J van Damme G M Jeunhomme W A Buurman 《The Journal of experimental medicine》1987,166(4):1180-1185
In conclusion, our observations indicate that the constitutive MHC class I expression is regulated by autocrine production of IFN-beta 1. TNF-alpha acts as an enhancer of the autocrine production of IFN-beta 1, and consequently as an enhancer of the MHC class I expression and viral protection. 相似文献
64.
High-field surface coil magnetic resonance (MR) images were obtained of 12 ankles: two from healthy volunteers, seven from patients, and three from fresh cadavers. The cadaver ankles were sectioned in the coronal, sagittal, and axial planes for direct comparison with the MR images. Plain film confirmation of pathologic conditions was obtained in all patients, and five underwent arthroscopy or surgery, or both. MR imaging provided excellent delineation of ligaments and cartilaginous structures in all cases. 相似文献
65.
Management of cerebral ischemia due to Takayasu''''s arteritis 总被引:2,自引:0,他引:2
Aortoarteritis ,alsocalledTakayasu’sarteritis ,isachronicidiopathicinflammatorydiseasethataffectslargeandmediumsizearteries Clinicalfeaturesreflectlimbororganischemiaresultingfromstenosistoobliterationofinvolvedarteries Thisdisease ,describedbyTakayasuin… 相似文献
66.
T J Ruers W A Buurman J F Smits C J van der Linden J J van Dongen H A Struyker-Boudier G Kootstra 《Transplantation》1986,41(2):156-161
A method is described for continuous administration of immunosuppressive drugs directly into rat renal allografts. The drug is given via a catheter, introduced into the suprarenal or testicular artery of the transplanted kidney. The cannula is connected to an implantable osmotic minipump that delivers an immunosuppressive drug with continuous flow for 13 days. It is demonstrated that the technique as such has no detrimental or enhancing effects on renal allograft survival. Depending upon the pharmacokinetic properties of the drug administered, this technique allows a more or less selective treatment of renal allograft rejection. The method was used to test the effect of intrarenal administration of prednisolone on renal allograft survival. Intrarenal administration of this drug appeared to be superior to any other way of administration tested. A low dose of 4 mg/kg body weight per day given by continuous intrarenal infusion results in significant prolongation of graft survival, whereas continuous systemic administration of this dose is not effective. To induce prolongation of graft survival by i.p. administration the prednisolone dose had at least to be doubled. The results prove that during graft rejection local events within the graft are vulnerable to prednisolone. It is concluded that local treatment of allograft rejection is possible and that this approach represents a potentially important way to manipulate the immune response. 相似文献
67.
68.
Utilization of target-specific, hypersensitive strains of Saccharomyces cerevisiae to determine the mode of action of antifungal compounds 下载免费PDF全文
Buurman ET Andrews B Blodgett AE Chavda JS Schnell NF 《Antimicrobial agents and chemotherapy》2005,49(6):2558-2560
Target-specific hypersusceptible strains of Saccharomyces cerevisiae were used to screen antifungal compounds. Two novel Erg7p inhibitors were identified, providing proof of principle of the approach taken. However, observed hypersensitivities to antifungals acting via other targets imply that use of this tool to identify the mode of action requires significant deconvolution. 相似文献
69.
BACKGROUND: Individuals with epilepsy or seizure disorders are restricted from donating blood because of concern that they are prone to adverse donor reactions such as syncope and convulsions. A study evaluating whether that concern is warranted is reported. STUDY DESIGN AND METHODS: During a 2-year period beginning in 1987, blood donors in Maryland with a history of seizures were actively recruited by the American Red Cross. Adverse donor reactions were classified as "slight", indicating dizziness and nausea without loss of consciousness; "moderate," denoting syncope; and "severe," indicating convulsive syncope. RESULTS: There were 329,143 satisfactory blood donations; 613 individuals reporting a history of seizures donated blood a total of 723 times. Among donors with seizures, 186 (35.7%) were taking antiepileptic medication, and 61 (8.4%) had had one or more seizures in the preceding year. Individuals with seizures had a low incidence of adverse reactions (3.34%). Although this incidence was slightly higher than that in the entire population (2.24%), the difference was not significant. In particular, the risk of syncope with or without convulsive activity was low for people with seizures (0.21%) and not significantly greater than that in other donors (0.28%). CONCLUSION: Individuals with seizures or epilepsy are not at greater risk for adverse reactions after blood donation, and major restrictions on their participation as blood donors are not warranted. 相似文献
70.
Gijs D Vos Wim A Buurman Dick A van Waardenburg Timo P L Visser Graham Ramsay Raymond A M G Donckerwolcke 《European journal of emergency medicine》2003,10(3):195-199
A recent development in providing intensive care for children is that it is more and more centralized in tertiary centres. The centralization of intensive care facilities for children in tertiary centres demands a safe and well-organized transport system. The transfer of critically ill children from a referring general hospital to a tertiary paediatric intensive care centre should be performed by a specially trained and fully equipped transport team. During the transfer of these children continuous intensive care facilities should be provided. The minimal requirements of equipment and materials for transport that allow such care have been determined. The equipment consists of a monitor allowing continuous measurement of vital signs, a defibrillator, tools for airway and ventilatory management, an oxygen source, suction unit, fluid and electrolyte management, medication, resuscitation chart and a communication system. A mobile paediatric intensive care unit was constructed in order to store this equipment, including easily accessible ventilator and materials optimized for close patient observation and ventilator control. 相似文献