EGF促进RPE细胞毒蕈碱受体诱导的磷酸肌醇形成：受体间交互作用分析

对培养人眼视网膜色素上皮（RPE）细胞磷酸肌醇（InsPs）水平的分析表明，Carbachol显著刺激RPE细胞InsPs水平的升高，且该效应可被阿托品所阻断，表明在人眼RPE细胞存在毒蕈碱受体。去甲肾上腺素、5-羟色胺、表皮生长因子（EGF）、异丙肾上腺素和NECA对InsPs基础水平无明显影响。异丙肾上腺素和NECA对Carbachol刺激InsPs的效应也无明显影响；但EGF显著促进Carbacol刺激人眼RPE细胞InsPs水平升高的效应。提示在人眼RPE细胞EGF与毒蕈碱受体之间存在有受体间交互作用。 （中华眼底病杂志，1994，10：220-222）     

Enabling a person with multiple disabilities and minimal motor behaviour to control environmental stimulation with chin movements

Purpose: To assess whether a young man with multiple disabilities and minimal motor behaviour would learn to control environmental stimulation using chin movements and a mechanical microswitch. Method: The study was carried out according to an ABAB design in which A represented baseline and B intervention phases. The chin movements controlled the stimulation only during the intervention phases. A 2-month post-intervention check was conducted. Results: The man increased the frequency of his chin movements, thus increasing the level of environmental stimulation, during the intervention phases. This performance was maintained at the post-intervention check. Conclusion: The use of chin movements is a practical strategy for enabling individuals with minimal motor movements to control environmental stimulation. Future research should examine whether similar types of movements may enable some individuals to control voice-output communication devices.     

芹菜甲素保护脑细胞的作用

以每周定时im马桑内酯0.9～1.5mg/kg三个月为实验性癫痫慢性发作模型。ig芹菜甲素700mg/kg能明显降低大鼠癲痫发作的程度和次数,延长潜伏期。脑形态学结果表明,芹菜甲素对大脑顶叶皮层细胞、胶质细胞和小脑蚓部蒲肯野细胞有一定的保护作用。同时观察的安定1.5～5mg/kg则无此作用。     

Simultaneous intrapleural resection of malignant tumors of the esophagus and cardioesophageal region]

Results of transpleural resection of esophageal and cardioesophageal tumors in 115 patients are discussed. Extensive combined access, formation of invagination anastomosis, preoperative preparation and intensive therapy for correction of homeostasis proved the basic elements of the therapeutic modality. The use of these elements assured lower postoperative lethality (13.9%), particularly, due to surgical complications (9.3%). In patients undergoing extensive combined resection, lethality rate was 10.0%. Intrapleural anastomosis failed in 5.7%.     

U22, a Protocol to Quantify Symptoms Associated with Supraventricular Tachycardia

Background: The main indication for ablation of supraventricular tachyarrhythmias (SVTA) is symptomatic relief. Specific paroxysmal symptoms cannot be quantified with general measures of quality of life, such as with the SF-36 questionnaire. U22 is a new protocol which measures the effects of arrhythmia on well-being, the intensity of discomfort during an episode, the type and temporal characteristics of dominant symptoms, and the duration and frequency of episodes. Discrete 0–10 scales are used. Unlike SF-36, U22 can be used in individual patients.
Methods: U22 and SF-36 protocols were used in the symptomatic evaluation of 88 patients (mean age = 49.6 ± 16.4 years; 43 men), who underwent catheter ablation of SVTA.
Results: The U22 scores (SD) for (a) well-being (10 being best), (b) effects of arrhythmia on well-being (10 being worst), and (c) discomfort during arrhythmia (10 being worst) were 5.6 (2.7), 7.5 (2.8), and 8.0 (2.4), respectively. For comparison, the physical and mental component summaries of SF-36 were 45.3 (11.0) and 45.2 (12.1), respectively, slightly lower than the expected normal of 50. The intensity of dominant symptom scored by U22 was 9.7 (1.2), 10 being worst. In 29% of patients ≥4 symptoms were equally dominant. Multiple dominant symptoms in U22 were associated with a low general well-being in SF-36.
Conclusion: We found U22 useful to quantify symptoms associated with SVTA.