全文获取类型
收费全文 | 33174篇 |
免费 | 2431篇 |
国内免费 | 55篇 |
专业分类
耳鼻咽喉 | 303篇 |
儿科学 | 1188篇 |
妇产科学 | 997篇 |
基础医学 | 4298篇 |
口腔科学 | 434篇 |
临床医学 | 4340篇 |
内科学 | 5935篇 |
皮肤病学 | 498篇 |
神经病学 | 3560篇 |
特种医学 | 607篇 |
外国民族医学 | 4篇 |
外科学 | 2980篇 |
综合类 | 348篇 |
一般理论 | 45篇 |
预防医学 | 4588篇 |
眼科学 | 505篇 |
药学 | 2226篇 |
中国医学 | 23篇 |
肿瘤学 | 2781篇 |
出版年
2024年 | 32篇 |
2023年 | 263篇 |
2022年 | 430篇 |
2021年 | 1119篇 |
2020年 | 680篇 |
2019年 | 1036篇 |
2018年 | 1157篇 |
2017年 | 833篇 |
2016年 | 980篇 |
2015年 | 1005篇 |
2014年 | 1328篇 |
2013年 | 1871篇 |
2012年 | 2735篇 |
2011年 | 2953篇 |
2010年 | 1545篇 |
2009年 | 1296篇 |
2008年 | 2377篇 |
2007年 | 2380篇 |
2006年 | 2179篇 |
2005年 | 2043篇 |
2004年 | 1831篇 |
2003年 | 1584篇 |
2002年 | 1597篇 |
2001年 | 212篇 |
2000年 | 171篇 |
1999年 | 211篇 |
1998年 | 308篇 |
1997年 | 243篇 |
1996年 | 170篇 |
1995年 | 182篇 |
1994年 | 134篇 |
1993年 | 122篇 |
1992年 | 78篇 |
1991年 | 53篇 |
1990年 | 53篇 |
1989年 | 44篇 |
1988年 | 45篇 |
1987年 | 36篇 |
1986年 | 45篇 |
1985年 | 23篇 |
1984年 | 26篇 |
1983年 | 35篇 |
1982年 | 28篇 |
1981年 | 21篇 |
1980年 | 17篇 |
1978年 | 13篇 |
1976年 | 11篇 |
1975年 | 10篇 |
1974年 | 17篇 |
1973年 | 14篇 |
排序方式: 共有10000条查询结果,搜索用时 359 毫秒
991.
Fang Yan Yu-Tao Xiang Ye-Zhi Hou Gabor S. Ungvari Lisa B. Dixon Sandra S. M. Chan Edwin H. M. Lee Weng-Yong Li Wen-Xiu Li Yu-Ling Zhu Helen F. K. Chiu 《Social psychiatry and psychiatric epidemiology》2013,48(3):447-454
Objectives
This study aimed to examine the prevalence and correlates of lifetime suicide attempts and current suicidal ideation in community-dwelling schizophrenia patients in China.Method
A sample of 540 schizophrenia patients was randomly selected in Beijing, China. All subjects were interviewed using standardized assessment instruments and their basic socio-demographic and clinical data including history of suicide attempts were collected.Results
The prevalence of lifetime suicide attempts and the point prevalence of suicidal ideation were 12.0 %, and 21.1 %, respectively. In multiple logistic regression analyses, the presence of lifetime suicide attempt was independently associated with rural residence, having major medical conditions and better social functioning, while higher likelihood of current suicidal ideation was associated with past suicide attempt, the severity of overall psychopathology and depressive symptoms and lower psychological quality of life (QOL).Conclusion
Among Chinese outpatients with schizophrenia, increased current symptoms and poorer QOL were correlated with current suicidal ideation, while demographic factors and indicators of greater social support were mostly correlated with lifetime suicide attempts. This study may help to identify important subgroups of patients with schizophrenia at particularly high risk of suicidal behavior. 相似文献992.
Varanasi VG Leong KK Dominia LM Jue SM Loomer PM Marshall GW 《The Journal of oral implantology》2012,38(4):325-336
This study tests the hypothesis that silicon and calcium ions combinatorially target gene expression during osteoblast differentiation. MC3T3-E1 subclone 4 osteoblast progenitors (transformed mouse calvarial osteoblasts) were exposed to Si(4+) (from Na(2)SiO(3)) and Ca(2+) (from CaCl(2):H(2)O) ion treatments both individually (0.4 mM each + control treatment) and combinatorially (0.4 mM Si(4+) + 0.4 mM Ca(2+) + control treatment) and compared to control treated (α-minimum essential medium, 10% fetal bovine serum, and 1% penicillin-streptomycin) cells. Cell proliferation studies showed no significant increase in cell density between treatments over 5 days of culture. Cellular differentiation studies involved addition of ascorbic acid (50 mg/L) for all treatments. Relative gene expression was determined for collagen type 1 (Col(I)α1/Col(I)α2), core-binding factor a (cbfa1/Runx2), and osteocalcin (OCN), which indicated osteoblast progenitor differentiation into a mineralizing phenotype. Increased Si(4+) or Ca(2+) ion treatments enhanced Col(I)α1, Col(I)α2, Runx2, and OCN expression, while increased Si(4+) + Ca(2+) ion treatments enhanced OCN expression. Moreover, it was found that a Si(4+)/Ca(2+) ratio of unity was optimal for maximal expression of OCN. Collagen fiber bundles were dense, elongated, and thick within extracellular matrices (ECM) exposed to Si(4+) and Si(4+) + Ca(2+) treatments, while collagen fiber bundles were sparse, short, and thin within Ca(2+) and control treated ECM. These results indicated that individual ions enhance multiple osteogenic gene expression, while combined ion treatments enhance individual gene expression. In addition, these results indicated that Si(4+) enhanced osteoblast gene expression and ECM formation at higher levels than Ca(2+). These results support the larger concept that ions (possibly released from bioactive glasses) could control bone formation by targeting osteoblast marker expression. 相似文献
993.
Jocelyn A. Silvester Isabel Comino Lisa N. Rigaux Veronica Segura Kathy H. Green Angel Cebolla Dayna Weiten Remedios Dominguez Daniel A. Leffler Francisco Leon Charles N. Bernstein Lesley A. Graff Ciaran P. Kelly Carolina Sousa Donald R. Duerksen 《Alimentary pharmacology & therapeutics》2020,52(9):1469-1479
994.
Kristen M. Johnson Julie J. Belfer Gina R. Peterson Mark R. Boelkins Lisa E. Dumkow 《Pharmacotherapy》2020,40(6):517-524
Novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome virus (SARS-CoV-2) has become a global health care crisis. The Centers for Disease Control and Prevention (CDC) lists immunocompromised patients, including those requiring immunosuppression following renal transplantation, as high risk for severe disease from SARS-CoV-2. Treatment for other viral infections in renal transplant recipients often includes a reduction in immunosuppression; however, no current guidelines are available recommending the optimal approach to managing immunosuppression in the patients who are infected with SARS-CoV-2. It is currently advised to avoid corticosteroids in the treatment of SARS-CoV-2 outside of critically ill patients. Recently published cases describing inpatient care of COVID-19 in renal transplant recipients differ widely in disease severity, time from transplantation, baseline immunosuppressive therapy, and the modifications made to immunosuppression during COVID-19 treatment. This review summarizes and compares inpatient immunosuppressant management strategies of recently published reports in the renal transplant population infected with SARS-CoV-2 and discusses the limitations of corticosteroids in managing immunosuppression in this patient population. 相似文献
995.
Use of a run-in period to decrease loss to follow-up in the Contact Lens and Myopia Progression (CLAMP) study 总被引:1,自引:0,他引:1
Rigid gas permeable (RGP) contact lenses are initially less comfortable to wear than spectacles. In previous studies evaluating the use of RGP contact lenses to control myopia, more subjects randomly assigned to wear RGP contact lenses have been lost to follow-up than spectacle wearers. Previous rigid contact lens myopia control studies have lost 44% and 47% of the rigid contact lens wearers. This unequal loss to follow-up may compromise the results of the study, so we conducted a run-in period prior to randomized treatment-group assignment to ensure that all participants could adapt to RGP contact lens wear. We enrolled 147 children ages 8-11 years with myopia in the run-in period. Of the 147 subjects, 116 (78.9%) were able to wear RGP contact lenses for at least 40 hours per week and reported that they were "usually comfortable" or "always comfortable." After 3 years, no subjects were lost to follow-up. The run-in period greatly reduced the loss to follow-up suffered by previous RGP contact lens myopia progression studies and may help provide more definitive answers regarding myopia control with RGP contact lenses. 相似文献
996.
997.
Duncan Amie Meinzen-Derr Jareen Ruble Lisa A. Fassler Carrie Stark Lori J. 《Journal of autism and developmental disorders》2022,52(2):938-949
Journal of Autism and Developmental Disorders - Adolescents with autism spectrum disorder (ASD) without an intellectual disability have daily living skills (DLS) impairments. An initial feasibility... 相似文献
998.
Biallelic AOPEP Loss-of-Function Variants Cause Progressive Dystonia with Prominent Limb Involvement
Michael Zech MD Kishore R. Kumar MBBS PhD FRACP Sophie Reining MD Janine Reunert PhD Michel Tchan MBBS PhD FRACP Lisa G. Riley PhD Alexander P. Drew PhD Robert J. Adam MA MBBS PhD FRACP FRCP Riccardo Berutti PhD Saskia Biskup MD Nicolas Derive PhD Somayeh Bakhtiari PhD Sheng Chih Jin PhD Michael C. Kruer MD Tanya Bardakjian MS Pedro Gonzalez-Alegre MD PhD Ignacio J. Keller Sarmiento MD Niccolo E. Mencacci MD PhD Steven J. Lubbe PhD Manju A. Kurian PhD Fabienne Clot PhD Aurélie Méneret MD PhD Jean-Madeleine de Sainte Agathe MD Victor S.C. Fung MBBS PhD FRACP Marie Vidailhet MD Matthias Baumann MD Thorsten Marquardt MD Juliane Winkelmann MD Sylvia Boesch MD 《Movement disorders》2022,37(1):137-147
999.
Parker Phil Banbury Sam de Rijk Lisa 《International journal of mental health and addiction》2022,20(4):2382-2399
International Journal of Mental Health and Addiction - There is a developing interest in recovery-based approaches, positive psychology and the importance of flourishing in alcohol use disorders... 相似文献
1000.
Courtney LR 《Emergency Medicine Clinics of North America》2004,22(1):153-165
Being able to hire the right team members, keeping them engaged ina professional and productive environment, and avoiding litigation help keep the team functioning and meeting the everyday goals of providing quality patient care. Although these topics may seem complex, medical providers and professionals have resources available to them, such as the Human Resources department, the Medical Director, senior management,and legal counsel.Hiring the right people, creating a positive work environment, and avoiding litigation are all common sense principals that are relevant regardless of profession, industry, or company. Understanding how to apply the principles and concepts of Human Resources and personnel management can seem overwhelming: however, asking for help from the resources mentioned previously and applying the common sense information found in this article will help one to be a successful leader and practitioner. 相似文献