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91.
Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: activation of the vertebrate homologue of the drosophila seven in absentia gene. 总被引:4,自引:1,他引:4 下载免费PDF全文
R B Amson M Nemani J P Roperch D Israeli L Bougueleret I Le Gall M Medhioub G Linares-Cruz F Lethrosne P Pasturaud L Piouffre S Prieur L Susini V Alvaro P Millasseau C Guidicelli H Bui C Massart L Cazes F Dufour H Bruzzoni-Giovanelli H Owadi C Hennion G Charpak A Telerman et al. 《Proceedings of the National Academy of Sciences of the United States of America》1996,93(9):3953-3957
We report the isolation of 10 differentially expressed cDNAs in the process of apoptosis induced by the p53 tamor suppressor. As a global analytical method, we performed a differential display of mRNA between mouse M1 myeloid leukemia cells and derived clone LTR6 cells, which contain a stably transfected temperature-sensitive mutant of p53. At 32 degrees C wild-type p53 function is activated in LTR6 cells, resulting in programmed cell death. Eight genes are activated (TSAP; tumor suppressor activated pathway), and two are inhibited (TSIP, tumor suppressor inhibited pathway) in their expression. None of the 10 sequences has hitherto been recognized as part of the p53 signaling pathway. Three TSAPs are homologous to known genes. TSAP1 corresponds to phospholipase C beta 4. TSAP2 has a conserved domain homologous to a multiple endocrine neoplasia I (ZFM1) candidate gene. TSAP3 is the mouse homologue of the Drosophila seven in absentia gene. These data provide novel molecules involved in the pathway of wild-type p53 activation. They establish a functional link between a homologue of a conserved developmental Drosophila gene and signal transduction in tumor suppression leading to programmed cell death. 相似文献
92.
Nguyen Van Hong Alfred Amambua-Ngwa Nguyen Quang Tuan Do Duy Cuong Nguyen Thi Huong Giang Nguyen Van Dung Ta Thi Tinh Nguyen Van Tien Bui Quang Phuc Tran Thanh Duong Anna Rosanas-Urgell Umberto D’Alessandro Jean-Pierre Van Geertruyden Annette Erhart 《Emerging infectious diseases》2014,20(7):1207-1210
Resistance to artemisinin derivatives, the most potent antimalarial drugs currently used, has emerged in Southeast Asia and threatens to spread to Africa. We report a case of malaria in a man who returned to Vietnam after 3 years in Angola that did not respond to intravenous artesunate and clindamycin or an oral artemisinin-based combination. 相似文献
93.
Tran Dac Phu Vu Ngoc Long Nguyen Tran Hien Phan Trong Lan Wayne Lowe Michelle S. McConnell Michael F. Iademarco Jeffrey M. Partridge James C. Kile Trang Do Patrick J. Nadol Hien Bui Diep Vu Kyle Bond David B. Nelson Lauren Anderson Kenneth V. Hunt Nicole Smith Paul Giannone John Klena Denise Beauvais Kristin Becknell Jordan W. Tappero Scott F. Dowell Peter Rzeszotarski May Chu Carl Kinkade 《MMWR. Morbidity and mortality weekly report》2014,63(4):77-80
94.
Michael F. T. Koehler Philippe Bergeron Edna F. Choo Kevin Lau Chudi Ndubaku Danette Dudley Paul Gibbons Brad E. Sleebs Carl S. Rye George Nikolakopoulos Chinh Bui Sanji Kulasegaram Wilhelmus J. A. Kersten BrianJ. Smith Peter E. Czabotar Peter M. Colman DavidC. S. Huang Jonathan B. Baell Keith G. Watson Lisa Hasvold Zhi-Fu Tao Le Wang AndrewJ. Souers Steven W. Elmore John A. Flygare Wayne J. Fairbrother Guillaume Lessene 《ACS medicinal chemistry letters》2014,5(6):662-667
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97.
Nguyen Trung Dung Tran Viet Thu To Van Nguyen Bui Minh Thuy Masahito Hatsukano Koichi Higashimine Shinya Maenosono Ziyi Zhong 《RSC advances》2020,10(7):3775
In this work, we report the facile hydrothermal synthesis of manganese cobaltite nanoparticles (MnCo2O4.5 NPs) which can efficiently activate peroxymonosulfate (PMS) for the generation of sulfate free radicals (SO4˙−) and degradation of organic dyes. The synthesized MnCo2O4.5 NPs have a polyhedral morphology with cubic spinel structure, homogeneously distributed Mn, Co, and O elements, and an average size less than 50 nm. As demonstrated, MnCo2O4.5 NPs showed the highest catalytic activity among all tested catalysts (MnO2, CoO) and outperformed other spinel-based catalysts for Methylene Blue (MB) degradation. The MB degradation efficiency reached 100% after 25 min of reaction under initial conditions of 500 mg L−1 Oxone, 20 mg L−1 MnCo2O4.5, 20 mg L−1 MB, unadjusted pH, and T = 25 °C. MnCo2O4.5 NPs showed a great catalytic activity in a wide pH range (3.5–11), catalyst dose (10–60 mg L−1), Oxone concentration (300–1500 mg L−1), MB concentration (5–40 mg L−1), and temperature (25–55 °C). HCO3−, CO32− and particularly Cl− coexisting anions were found to inhibit the catalytic activity of MnCo2O4.5 NPs. Radical quenching experiments revealed that sulfate radicals are primarily responsible for MB degradation. A reaction sequence for the catalytic activation of PMS was proposed. The as-prepared MnCo2O4.5 NPs could be reused for at least three consecutive cycles with small deterioration in their performance due to low metal leaching. This study suggests a facile route for synthesizing MnCo2O4.5 NPs with high catalytic activity for PMS activation and efficient degradation of organic dyes.Catalytic degradation of organic dyes via manganese cobaltite nanoparticles-activated peroxymonosulfate. 相似文献
98.
The Vietnamese Mekong Delta is predicted to be one of the regions most impacted by climate change, causing increased temperature and salinity in inland waters. We hypothesized that the increase in temperature and salinity may impact the microcystin (MC) production of two Microcystis strains isolated in this region from a freshwater pond (strain MBC) and a brackish water pond (strain MTV). The Microcystis strains were grown at low (27 °C), medium (31 °C), high (35 °C) and extremely high (37 °C) temperature in flat photobioreactors (Algaemist). At each temperature, when cultures reached a stable state, sea salt was added to increase salinity to 4‰, 8‰, 12‰ and 16‰. MC concentrations and cell quota were reduced at high and extremely high temperatures. Salinity, in general, had comparable effects on MC concentrations and quota. At a salinity of 4‰ and 8‰, concentrations of MC per mL of culture and MC cell quota (based on chlorophyll, dry-weight and particle counts) were higher than at 0.5‰, while at the highest salinities (12‰ and 16‰) these were strongly reduced. Strain MBC produced five MC variants of which MC-RR and MC-LR were most abundant, followed by MC-YR and relatively low amounts of demethylated variants dmMC-RR and dmMC-LR. In strain MTV, MC-RR was most abundant, with traces of MC-YR and dmMC-RR only in cultures grown at 16‰ salinity. Overall, higher temperature led to lower MC concentrations and cell quota, low salinity seemed to promote MC production and high salinity reduced MC production. Hence, increased temperature and higher salinity could lead to less toxic Microcystis, but since these conditions might favour Microcystis over other competitors, the overall biomass gain could offset a lower toxicity. 相似文献
99.
Pham Van Trinh Nguyen Ngoc Anh Nguyen Thi Cham Le Tuan Tu Nguyen Van Hao Bui Hung Thang Nguyen Van Chuc Cao Thi Thanh Phan Ngoc Minh Naoki Fukata 《RSC advances》2022,12(17):10514
Herein, the effect of nanostructured silicon and gold nanoparticles (AuNPs) on the power conversion efficiency (PCE) of an n-type silicon/poly(3,4-ethylene dioxythiophene):poly(styrene sulfonate) (n-Si/PEDOT:PSS) hybrid solar cell was investigated. The Si surface modified with different nanostructures including Si nanopyramids (SiNPs), Si nanoholes (SiNHs) and Si nanowires (SiNWs) was utilized to improve light trapping and photo-carrier collection. The highest power conversion efficiency (PCE) of 8.15% was obtained with the hybrid solar cell employing SiNWs, which is about 8%, 20% and 40% higher compared to the devices using SiNHs, SiNPs and planar Si, respectively. The enhancement is attributed to the low reflectance of the SiNW structures and large PEDOT:PSS/Si interfacial area. In addition, the influence of AuNPs on the hybrid solar cell''s performance was examined. The PCE of the SiNW/PEDOT:PSS hybrid solar cell with 0.5 wt% AuNP is 8.89%, which is ca. 9% higher than that of the device without AuNPs (8.15%). This is attributed to the increase in the electrical conductivity and localized surface plasmon resonance of the AuNP-incorporated PEDOT:PSS coating layer.n-Si/PEDOT:PSS hybrid solar cells using nanostructured silicon and AuNPs were prepared and investigated. 相似文献
100.
Nguyen Ha Anh Mai Quan Doan Ngo Xuan Dinh Tran Quang Huy Doan Quang Tri Le Thi Ngoc Loan Bui Van Hao Anh-Tuan Le 《RSC advances》2022,12(18):10950
Modern society has been facing serious health-related problems including food safety, diseases and illness. Hence, it is urgent to develop analysis methods for the detection and control of food contaminants, disease biomarkers and pathogens. As the traditional instrumental methods have several disadvantages, including being time consuming, and having high cost and laborious procedures, optical nanosensors have emerged as promising alternative or complementary approaches to those traditional ones. With the advantages of simple preparation, high surface-to-volume ratio, excellent biocompatibility, and especially, unique optical properties, gold nanoparticles (AuNPs) have been demonstrated as excellent transducers for optical sensing systems. Herein, we provide an overview of the synthesis of AuNPs and their excellent optical properties that are ideal for the development of optical nanosensors based on local surface plasmon resonance (LSPR), colorimetry, fluorescence resonance energy transfer (FRET), and surface-enhanced Raman scattering (SERS) phenomena. We also review the sensing strategies and their mechanisms, as well as summarizing the recent advances in the monitoring of food contaminants, disease biomarkers and pathogens using developed AuNP-based optical nanosensors in the past seven years (2015–now). Furthermore, trends and challenges in the application of these nanosensors in the determination of those analytes are discussed to suggest possible directions for future developments.We provide an overview of the synthesis of AuNPs and their excellent optical properties for the development of optical nanosensors including colorimetric, fluorescence resonance energy transfer, and surface-enhanced Raman scattering sensors. 相似文献