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101.
Infection of laboratory rats with a new cytomegalo-like virus 总被引:7,自引:0,他引:7
This report described the infection of two strains of laboratory rats with a ratvirus (RA-1) with cytomegalovirus-like characteristics. The virus was detected in the spleens and kidneys during the first week post infection. In the salivary glands maximal virus titer was reached at one month post infection; thereafter the titer declined. In Lewis rats virus could be detected in the salivary homogenate of most animals at more than 12 months post infection. In BN rats, in contrast, virus became undetectable in the salivary glands of most animals 5 months after inoculation. However, administration of cyclophosphamide or X-irradiation resulted in reactivation of the virus in virtually all animals. Co-cultivation of spleen cells from either latently or chronically infected animals resulted in recovery of virus. The animals developed antibodies and a T-cell mediated virus specific cytotoxicity. 相似文献
102.
No?l?BB?Knops Kommer?CA?Sneeuw Ronald?Brand Elysee?TM?Hille A?Lya?den Ouden Jan-Maarten?WitEmail author S?Pauline?Verloove-Vanhorick 《BMC pediatrics》2005,5(1):26
Background
Improved survival due to advances in neonatal care has brought issues such as postnatal growth and development more to the focus of our attention. Most studies report stunting in children born very preterm and/or small for gestational age. In this article we study the growth pattern of these children and aim to identify factors associated with postnatal catch-up growth. 相似文献103.
Background
In 2002, the World Health Organization published a health system performance ranking for 191 member countries. The ranking was based on five indicators, with fixed weights common to all countries.Methods
We investigate the feasibility and desirability of using mathematical programming techniques that allow weights to vary across countries to reflect their varying circumstances and objectives.Results
By global distributional measures, scores and ranks are found to be not very sensitive to changes in weights, although differences can be large for individual countries.Conclusions
Building the flexibility of variable weights into calculation of the performance index is a useful way to respond to the debates and criticisms appearing since publication of the ranking. 相似文献104.
The function of the glutathione-related detoxification system plays an important role to ensure an uncomplicated pregnancy outcome. This study was performed to investigate whether the components of the glutathione-related detoxification system are equally distributed among the different cotelydons in the human placenta. We measured glutathione, cysteine, glutathione S-transferase (GST) isoenzyme levels (GSTA1+A2, GSTP1, GSTM1 and GSTT1), enzyme activities of glutathione S-transferase and glutathione peroxidases, protein carbonyl levels, and antioxidant capacities at twelve different standardized positions in six placentae from healthy women after uncomplicated pregnancy and vaginal delivery. Data were statistically evaluated with a Friedman two-way ANOVA with Bonferroni correction. 'Foetal'-side values were not significantly different from those at the 'maternal'-side. Except for GSTA1+A2, no significant differences were found between different sampling sites indicating that the distribution of all parameters measured was homogenous throughout the placenta. Since levels of GSTA1+A2 were minor compared to those of GSTP1 and GSTT1, the clinical relevance of this heterogeneity may be limited. These results implicate that the location of sampling is not important as long as biopsies are taken from physiological cotelydons. 相似文献
105.
106.
Ventral hernia repair: a study of current practice 总被引:5,自引:5,他引:0
Ventral wall hernias are common; despite this, there are no guidelines on the best surgical management. The aim of this study
was to examine the types of repair in use for abdominal wall hernias in the West of Scotland over a 3-month period. Data were
gathered on 120 patients. There were 60 incisional, 32 umbilical, and 28 epigastric hernias. The main indication for repair
was pain (78%), while 12 patients (10%), presented acutely with incarceration or strangulation. The most common method of
repair was sutured (55%), followed by mesh (29%) and Mayo repair (16%). There was no correlation between use of mesh and hernia
size or whether repair was for a recurrent hernia. Surgical practice varies widely in the repair of ventral wall hernias.
Clinical trials are required to establish the best method of repair for this common condition.
Electronic Publication 相似文献
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Bruggeman CA 《Herpes : the journal of the IHMF》2000,7(2):51-54
In vitro experiments, as well as experiments using animal models, suggest that cytomegalovirus (CMV) infection can stimulate atherosclerosis. There is also evidence that CMV stimulates the development of restenosis and transplantation-associated arteriosclerosis. Activation of arterial cells, enhancement of the inflammatory response and induction of cytokine production may all be important in mediating these effects. Further experiments, especially in animals susceptible to atherosclerosis and in patients with cardiovascular disease, will be necessary to elucidate the role of CMV, and also that of other infectious agents, in atherosclerosis. 相似文献