全文获取类型
收费全文 | 514篇 |
免费 | 18篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 6篇 |
妇产科学 | 4篇 |
基础医学 | 37篇 |
口腔科学 | 12篇 |
临床医学 | 26篇 |
内科学 | 69篇 |
皮肤病学 | 4篇 |
神经病学 | 9篇 |
特种医学 | 107篇 |
外科学 | 63篇 |
综合类 | 6篇 |
一般理论 | 1篇 |
预防医学 | 5篇 |
眼科学 | 1篇 |
药学 | 20篇 |
肿瘤学 | 161篇 |
出版年
2022年 | 2篇 |
2021年 | 7篇 |
2020年 | 12篇 |
2019年 | 8篇 |
2018年 | 9篇 |
2017年 | 5篇 |
2016年 | 12篇 |
2015年 | 11篇 |
2014年 | 19篇 |
2013年 | 9篇 |
2012年 | 18篇 |
2011年 | 9篇 |
2010年 | 13篇 |
2009年 | 13篇 |
2008年 | 12篇 |
2007年 | 20篇 |
2006年 | 24篇 |
2005年 | 21篇 |
2004年 | 32篇 |
2003年 | 34篇 |
2002年 | 22篇 |
2001年 | 18篇 |
2000年 | 13篇 |
1999年 | 14篇 |
1998年 | 15篇 |
1997年 | 13篇 |
1996年 | 12篇 |
1995年 | 6篇 |
1994年 | 11篇 |
1993年 | 7篇 |
1992年 | 5篇 |
1991年 | 4篇 |
1990年 | 5篇 |
1989年 | 8篇 |
1988年 | 11篇 |
1987年 | 7篇 |
1986年 | 10篇 |
1985年 | 8篇 |
1984年 | 4篇 |
1983年 | 5篇 |
1982年 | 7篇 |
1981年 | 4篇 |
1980年 | 13篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1973年 | 2篇 |
1969年 | 4篇 |
排序方式: 共有532条查询结果,搜索用时 15 毫秒
91.
92.
Alessandro Inno Giuseppe Fanetti Maria Di Bartolomeo Stefania Gori Claudia Maggi Massimo Cirillo Roberto Iacovelli Federico Nichetti Antonia Martinetti Filippo de Braud Ilaria Bossi Filippo Pietrantonio 《World Journal of Clinical Cases》2014,2(12):835-839
O6-methylguanine DNA methyltransferase (MGMT) gene promoter methylation plays an important role in colorectal carcinogenesis, occurring in about 30%-40% of metastatic colorectal cancer. Its prognostic role has not been defined yet, but loss of expression of MGMT, which is secondary to gene promoter methylation, results in an interesting high response to alkylating agents such as dacarbazine and temozolomide. In a phase 2 study on heavily pre-treated patients with MGMT methylated metastatic colorectal cancer, temozolomide achieved about 30% of disease control rate. Activating mutations of RAS or BRAF genes as well as mismatch repair deficiency may represent mechanisms of resistance to alkylating agents, but a dose-dense schedule of temozolomide may potentially restore sensitivity in RAS-mutant patients. Further development of temozolomide in MGMT methylated colorectal cancer includes investigation of synergic combinations with other agents such as fluoropyrimidines and research for additional biomarkers, in order to better define the role of temozolomide in the treatment of individual patients. 相似文献
93.
Giulia Galli Anna Tessari Luca Porcu Giacomo Bregni Biagio Paolini Maria Luisa Carcangiu Massimiliano Gennaro Maria Carmen De Santis Laura Lozza Filippo de Braud Serena Di Cosimo 《Breast cancer (Tokyo, Japan)》2017,24(4):635-641
Background
Complete response (CR) in metastatic breast cancer (MBC) is rare. This study aims at analyzing the characteristics and outcome of MBC patients achieving CR.Methods
We performed a cross-sectional analysis of clinical data from a consecutive series of MBC patients admitted at the Division of Medical Oncology of Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, achieving CR following treatment for systemic disease and with at least 2 years of follow-up.Results
Seventy-six MBC patients with CR were identified during a calendar year. 47 patients (61.8%) achieved CR more than once, for a total of 123 cases. Median age at MBC diagnosis was 56 years (range 30–76). 52 patients (68.4%) presented with recurrent disease, 24 (31.6%) with de novo metastatic disease. The majority of patients (80.3%) had hormone receptor (HR) positive and 26 (34.2%) had HER2 overexpressing MBC. 54 patients (71.1%) had only one site of metastatic disease. 33 patients (43.4%) received a local approach as part of their treatment and 67 (54.5%) achieved CR during maintenance therapy. CRs were durable, as after a median follow-up of 8.3 years (interquartile range 5.8–11.0 years) 42 patients (55.3%) were alive with no evidence of disease.Conclusions
Durable CRs can occur after systemic therapy alone or after combined systemic and local treatments. Most cases presented CR in the presence of limited disease spreading, not necessarily on first-line therapy. Our study highlights the crucial role of multidisciplinary approach to MBC and the benefit of maintenance treatment.94.
Heather Wakelee Zanete Zvirbule Filippo De Braud C. Daniel Kingsley Tarek Mekhail Thomas Lowe Wolfgang Schütte Hervé Lena William Lawler Fadi Braiteh Thomas Cosgriff Diego Kaen Michelle Boyer Jessie Hsu See Phan Silvia Novello 《Clinical lung cancer》2017,18(1):50-59
Background
Onartuzumab is a monovalent monoclonal antibody that binds with the extracellular domain of the MET receptor. Given the role of MET in non–small-cell lung cancer (NSCLC), we investigated whether onartuzumab added to first-line chemotherapy efficacy in non-squamous NSCLC.Methods
Patients with untreated stage IIIB/IV non-squamous NSCLC, stratified by MET diagnostic status, were randomized to receive onartuzumab (15 mg/kg intravenously every 3 weeks) or placebo in combination with either paclitaxel/platinum/bevacizumab (bevacizumab cohort), or in combination with platinum/pemetrexed (pemetrexed cohort) with maintenance bevacizumab or pemetrexed and onartuzumab/placebo as appropriate. Co-primary endpoints of this phase II study were progression-free survival (PFS) in all patients and in MET+ patients (2+/3+), defined by the Ventana immunohistochemistry assay; secondary endpoints included overall survival (OS), objective response rate (ORR), safety, and pharmacokinetics.Results
Efficacy data were available for 139 and 120 patients in the bevacizumab and pemetrexed cohorts, respectively. No benefit was seen in the PFS endpoint in the intent-to treat population of either cohort, but was numerically worse in the onartuzumab arm of the MET+ subgroup of the bevacizumab cohort. The onartuzumab and placebo arms had similar ORR and OS results in both cohorts. A higher incidence of some adverse events was observed with onartuzumab versus placebo, including peripheral edema (30% vs. 3%, bevacizumab cohort; 48% vs. 14%, pemetrexed cohort) and venous thromboembolic events (bevacizumab cohort only, 15% vs. 6%).Conclusion
Onartuzumab does not appear to provide any additional clinical benefit when given in combination with current first-line standard-of-care chemotherapy for non-squamous NSCLC. 相似文献95.
S Arnaud G Houvenaeghel V Moutardier M Butarelli M Martino A Tallet A C Braud J Jacquemier C Julian-Reynier I Brenot-Rossi 《European journal of surgical oncology》2004,30(7):735-743
AIMS: The objectives of this study were to compare the postoperative morbidity of Sentinel lymph node biopsy (SLNB) and axillary lymph node dissection (ALND) and to compare the views of surgeons and patients regarding postoperative morbidity. METHODS: A prospective and comparative study was initiated to evaluate, 1 year after surgery, morbidity and sequelae after SLNB in 231 patients. Group I (n=141) underwent SLNB without ALND, group II (n=90) underwent SLNB followed by ALND when SLN where involved. Morbidity analysis was performed, respectively, by surgeons and patients. RESULTS: One hundred and eighty-five patients (80.5%) completed the questionnaire including 113 with SLNB alone, and 72 with ALND. One year after surgery, SLNB produced less morbidity than ALND for symptoms and function. There were significantly different assessments between surgeons and patients for pain, arm mobility and sensitiveness. CONCLUSIONS: One-year postoperative morbidity after SLNB is significantly lower than after ALND but views of surgeons and patients appears to be significantly different. Additional data are required to assess late consequences of axillary surgery. 相似文献
96.
Fazio N.; De Pas T.; de Braud F.; Spaggiari L.; Mazzarol G.; Biffi R.; Andreoni B.; Zampino M.; Curigliano G.; Lorizzo K.; Di Meglio G.; Goldhirsch A. 《Annals of oncology》2004,15(12):1850
Two Cdx homeobox genes have been identified so far in humans[1, 2]. CDX-2 is the product of the Cdx-2 homeobox gene andis expressed in normal colonic epithelia and most colorectaladenocarcinomas. Lung and pleural neoplastic lesions requirethe distinction between primary and metastatic malignancy whenoccurring alone. Colorectal 相似文献
97.
98.
99.
100.
Raffaele Ratta Elena Verzoni Massimo Di Maio Paolo Grassi Maurizio Colecchia Giovanni Fucà Filippo de Braud Giuseppe Procopio 《Clinical genitourinary cancer》2018,16(4):e735-e742