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1.
Twenty two patients (age range: 1 month to 11 years) were treated for congenital diaphragmatic defects (excluding hiatus hernia) in the six year period 1983-8. Presenting features were failure to thrive (n = 7), abdominal pain and vomiting (n = 4), chronic respiratory symptoms (n = 3), and inability to wean from ventilatory support (n = 3). The defect was an incidental finding in five patients. Operative repair was performed with no mortality or serious postoperative morbidity. Dramatic improvement occurred in 15 of the 17 symptomatic patients. Awareness of the differential diagnosis should avoid delay in diagnosis or inappropriate treatment. Surgical correction is strongly recommended in all cases. 相似文献
2.
Action of calcitonin gene-related peptide upon bovine vascular endothelial and smooth muscle cells grown in isolation and co-culture. 总被引:3,自引:2,他引:1 下载免费PDF全文
D. C. Crossman M. R. Dashwood S. D. Brain J. McEwan J. D. Pearson 《British journal of pharmacology》1990,99(1):71-76
1. Bovine aortic endothelial cells (BAE) and smooth muscle cells (BASM) were grown separately and in co-culture. 2. Calcitonin gene-related peptide (CGRP) caused dose-dependent activation of adenylate cyclase in each cell type when grown in isolation. The concentration of CGRP causing half-maximal activation in BAE and BASM was 200 nM and 310 nM, respectively. 3. In cells grown in co-culture exposure to bradykinin produced dose-dependent elevations in cyclic GMP content which were maximal 1 min after application of the agonist. 4. CGRP (1 nM-1 microM) did not stimulate a rise in cyclic GMP in co-cultures. 5. Displaceable CGRP binding was identified throughout the wall of the bovine aorta. 6. We conclude that CGRP receptors coupled to adenylate cyclase are present on BAE and BASM, but there is no coupling of these receptors to the release of any agent (such as endothelium-derived relaxing factor) that activates guanylate cyclase. 相似文献
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A new prototype of the laryngeal mask airway (LMA), the intubating
laryngeal mask airway (ILMA), was used to facilitate tracheal intubation in
100 fasted patients presenting for elective surgery. Alignment of the ILMA
with the larynx was assessed fibreoptically before intubation without the
investigator performing the intubation being aware of the view score. Ease
of intubation correlated with the view obtained and with the degree of
manipulation of the ILMA needed to achieve tracheal intubation. Intubation
was successful in 93 patients. Of the seven intubation failures, five
occurred in the first 20 patients. Conventional connection to the breathing
system and ventilation of the lungs of the patients were possible
throughout the intubation procedure.
相似文献
6.
Calcitonin gene-related peptide increases blood flow and potentiates plasma protein extravasation in the rat knee joint. 下载免费PDF全文
1. The effects of calcitonin gene-related peptide (CGRP) and other vasoactive mediators of inflammation on blood flow in the synovial vessels and plasma protein extravasation into the knee (femoro-tibial) joint of the pentobarbitone-anaesthetized rat were measured. 2. Changes in synovial blood flow were estimated by 133xenon clearance from the synovial cavity. CGRP (0.1 pmol and 10 pmol) and prostaglandin E1 (PGE1; 3 pmol and 300 pmol) significantly increased clearance from the knee joint measured 5 min after intra-articular injection. Substance P (10 pmol) had no effect on synovial blood flow. 3. Intra-articular perfusion of the rat knee with CGRP at concentrations up to 0.1 mM, or PGE1 at concentrations up to 10 microM, did not increase plasma extravasation into the synovial cavity measured by accumulation of intravenously injected 125I-albumin in the perfusate. 4. Plasma extravasation into the knee was significantly increased by infusion of bradykinin (0.1 microM), 5-hydroxytryptamine (1 microM) and histamine (0.1 mM), compared with the contralateral joints in the same animals which were perfused with Tyrode solution. 5. Perfusion of the knee joint with substance P did not specifically induce 125I-labelled albumin accumulation in the synovial cavity even at doses that had systemic effects as observed by marked plasma extravasation into other tissues. 6. The increase in plasma extravasation induced by histamine (0.1 mM) was potentiated by co-infusion with CGRP (0.1 microM) and PGE1 (3 microM). However the response to a submaximal dose (0.1 microM) of bradykinin, which induced similar plasma extravasation to histamine (0.1 mM), was not increased by co-infusion with CGRP or PGE1.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
7.
V S Perez M Martinez D Castano P F Brain S Hasan 《The International journal of neuroscience》1988,41(3-4):231-240
An attempt was made in two experiments to reinvestigate the effects of the antiandrogen cyproterone acetate (CA) on mouse social behavior in a variety of ethologically-assessed paired encounters. The data confirm that CA reduces offense (threat and attack) in animals when both subjects receive the material but that CA has no such action in other pairings. This suggests that CA's major suppressive effect on "hostility" is expressed in mice via a reduction in "attack-promoting" pheromone production. Indeed, there was evidence in the more chronic study that CA, could augment (via a central mechanism?) offense in subjects paired with docile anosmic opponents. Changes in defense were largely responses to variations in the degree of attack to which animals were subjected. The antihormone also had actions on other aspects of behavior including sexual activity, social investigation and immobility in such tests. CA had a potent suppressive action on the weights of sex accessory glands. The data do not suggest that CA can be used as a specific antihostility agent. 相似文献
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精神病人手术治疗前后WMS、WAIS测试结果分析 总被引:1,自引:0,他引:1
目的 探讨精神病的外科手术疗法对病人脑功能的损害。方法 应用韦氏记忆 ( WMS)、智力 ( WAIS)量表分别对1 0名精神病人进行手术治疗前后的测试。结果 精神病人手术治疗前后 ,记忆、智力量表分没有显著差异 ( P>0 .0 5 )。结论 精神病的外科治疗对病人的脑功能没有不良影响。 相似文献
10.
电刺激杏仁核对猫丘脑后核内脏大神经诱发放电的抑制作用 总被引:2,自引:0,他引:2
本文使用条件—检验刺激技术,研究了电刺激杏仁皮质内侧核对猫丘脑后核内脏大神经诱发放电的影响。电刺激杏仁皮质内侧核抑制丘脑后核的中等和长潜伏期内脏大神经诱发放电呈现两种形式:即时抑制和迟发抑制。前者可能是通过从杏仁核到丘脑后核的神经通路产生的,静脉注射纳洛酮可消除这种抑制,提示有鸦片样物质的参与。后者可能涉及神经—体液性因素。结果提示,杏仁核参与抑制内脏痛。 相似文献