全文获取类型
收费全文 | 2028篇 |
免费 | 103篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 27篇 |
儿科学 | 92篇 |
妇产科学 | 42篇 |
基础医学 | 295篇 |
口腔科学 | 125篇 |
临床医学 | 143篇 |
内科学 | 367篇 |
皮肤病学 | 31篇 |
神经病学 | 145篇 |
特种医学 | 171篇 |
外国民族医学 | 1篇 |
外科学 | 303篇 |
综合类 | 68篇 |
预防医学 | 137篇 |
眼科学 | 24篇 |
药学 | 78篇 |
中国医学 | 5篇 |
肿瘤学 | 84篇 |
出版年
2023年 | 7篇 |
2022年 | 20篇 |
2021年 | 46篇 |
2020年 | 31篇 |
2019年 | 46篇 |
2018年 | 41篇 |
2017年 | 45篇 |
2016年 | 34篇 |
2015年 | 43篇 |
2014年 | 62篇 |
2013年 | 99篇 |
2012年 | 111篇 |
2011年 | 109篇 |
2010年 | 99篇 |
2009年 | 88篇 |
2008年 | 107篇 |
2007年 | 95篇 |
2006年 | 74篇 |
2005年 | 99篇 |
2004年 | 76篇 |
2003年 | 75篇 |
2002年 | 56篇 |
2001年 | 33篇 |
2000年 | 39篇 |
1999年 | 45篇 |
1998年 | 40篇 |
1997年 | 40篇 |
1996年 | 43篇 |
1995年 | 42篇 |
1994年 | 35篇 |
1993年 | 28篇 |
1992年 | 20篇 |
1991年 | 22篇 |
1990年 | 23篇 |
1989年 | 36篇 |
1988年 | 28篇 |
1987年 | 25篇 |
1986年 | 22篇 |
1985年 | 16篇 |
1984年 | 19篇 |
1983年 | 25篇 |
1982年 | 16篇 |
1981年 | 15篇 |
1980年 | 16篇 |
1979年 | 8篇 |
1978年 | 8篇 |
1977年 | 3篇 |
1976年 | 8篇 |
1975年 | 5篇 |
1973年 | 6篇 |
排序方式: 共有2138条查询结果,搜索用时 15 毫秒
41.
Background
Over the last 20 years, an increasing number of people have immigrated into Italy. On January 1, 2011, there were 4,570,317 foreign residents in Italy, including 398,910 in the Piedmont region (Italian National Statistics Institute data). The Romanian community was the largest, followed by the Moroccan and Albanian ones. The numbers are even layer if we consider illegal immigrants. As a result, the number of foreign people with brain death has increased, as well as the number of foreign people needing organ transplantations.Methods
The Piedmont Regional Coordination Agency of Tissue and Organ Procurement has analyzed our 1781 brain death situations between January 2004 and December 2011, including 126 (7%) in people not born in Italy (migrants).Results
Non-refusal for donation occurred in 79 cases (62.7%). The agency also analyzed each community looking at number of brain deaths and non-refusals of donation. We utilized 61 donors, for 174 transplantations. Migrants in Italy are not only potential tissue and organ donors, but also potential tissue and organ recipients. Between 2004 and 2011, 222 patients who had not been born in Italy had been transplanted with: a liver (n = 66), a kidney (n = 130), a heart (n = 21) or a lung (n = 5). 相似文献42.
Ran Schwarzkopf Fabio M. Sagebin Raj Karia Karl M. Koenig Joseph A. Bosco James D. Slover 《The Journal of arthroplasty》2013
Rising implant prices and evolving technologies are important factors contributing to the increased cost of arthroplasty. Assessing how patients value arthroplasty, new technologies, and their perceived outcomes is critical in planning cost-effective care, as well as evaluating new-technologies. One hundred one patients undergoing arthroplasty took part in the survey. We captured demographics, spending practices, knowledge of implants, patient willingness to pay for implants, and preferences related to implant attributes. When patients were asked if they would be satisfied with “standard of care” prosthesis, 80% replied “no”. When asked if they would pay for a higher than “standard of care” prosthesis, 86% replied “yes”. The study demonstrated that patients, regardless of their socio-economic status, are not satisfied with standard of care implants when newer technologies are available, and they may be willing to share in the cost of their prosthesis. Patients also prefer the option to choose what they perceive to be a higher quality or innovative implant even if the “out of pocket” cost is higher. 相似文献
43.
44.
Donna L. Berry Barbara Halpenny Fangxin Hong Seth Wolpin William B. Lober Kenneth J. Russell William J. Ellis Usha Govindarajulu Jaclyn Bosco B. Joyce Davison Gerald Bennett Martha K. Terris Andrea Barsevick Daniel W. Lin Claire C. Yang Greg Swanson 《Urologic oncology》2013,31(7):1012-1021
ObjectiveThe purpose of this trial was to compare usual patient education plus the Internet-based Personal Patient Profile-Prostate, vs. usual education alone, on conflict associated with decision making, plus explore time-to-treatment, and treatment choice.MethodsA randomized, multi-center clinical trial was conducted with measures at baseline, 1-, and 6 months. Men with newly diagnosed localized prostate cancer (CaP) who sought consultation at urology, radiation oncology, or multi-disciplinary clinics in 4 geographically-distinct American cities were recruited. Intervention group participants used the Personal Patient Profile-Prostate, a decision support system comprised of customized text and video coaching regarding potential outcomes, influential factors, and communication with care providers. The primary outcome, patient-reported decisional conflict, was evaluated over time using generalized estimating equations to fit generalized linear models. Additional outcomes, time-to-treatment, treatment choice, and program acceptability/usefulness, were explored.ResultsA total of 494 eligible men were randomized (266 intervention; 228 control). The intervention reduced adjusted decisional conflict over time compared with the control group, for the uncertainty score (estimate ?3.61; (confidence interval, ?7.01, 0.22), and values clarity (estimate ?3.57; confidence interval (?5.85,?1.30). Borderline effect was seen for the total decisional conflict score (estimate ?1.75; confidence interval (?3.61,0.11). Time-to-treatment was comparable between groups, while undecided men in the intervention group chose brachytherapy more often than in the control group. Acceptability and usefulness were highly rated.ConclusionThe Personal Patient Profile-Prostate is the first intervention to significantly reduce decisional conflict in a multi-center trial of American men with newly diagnosed localized CaP. Our findings support efficacy of P3P for addressing decision uncertainty and facilitating patient selection of a CaP treatment that is consistent with the patient values and preferences. 相似文献
45.
46.
47.
Spatial anisotropy in the encoding of three-dimensional passive limb position by the spinocerebellum
In an earlier study, we found that the encoding of limb position in the sagittal plane across the population of spinocerebellar Purkinje cells was anisotropic with a preferential gradient along horizontal direction. The aim of this study was to extend to a three-dimensional (3D) workspace the analysis of the relationships between Purkinje cells activity and rat's forelimb spatial position. In anesthetized animals, the extracellular activity of 121 neurons was recorded while a robot passively placed the limb in 18 positions within a cubic workspace (3x3x3 cm). In order to characterize the relationship between spatial locations and Purkinje cell activity we performed a backward stepwise regression starting from a model with three independent variables representing the antero-posterior, the medial-lateral and the vertical axes of workspace. Regression analysis showed that the firing of most cells was modulated exclusively along the antero-posterior (25%) or the medial-lateral (38%) axis, while a small portion was related only to the vertical axis (8%), indicating a generalized nonuniform sensitivity of Purkinje cells to limb displacement in 3D space. 相似文献
48.
Fanny Lebreton Kevin Bellofatto Charles H. Wassmer Lisa Perez Vanessa Lavallard Graldine Parnaud David Cottet‐Dumoulin Julie Kerr‐Conte Franois Pattou Domenico Bosco Vronique Othenin‐Girard Begoa Martinez de Tejada Ekaterine Berishvili 《American journal of transplantation》2020,20(6):1551-1561
Hypoxia is a major cause of considerable islet loss during the early posttransplant period. Here, we investigate whether shielding islets with human amniotic epithelial cells (hAECs), which possess anti‐inflammatory and regenerative properties, improves islet engraftment and survival. Shielded islets were generated on agarose microwells by mixing rat islets (RIs) or human islets (HI) and hAECs (100 hAECs/IEQ). Islet secretory function and viability were assessed after culture in hypoxia (1% O2) or normoxia (21% O2) in vitro. In vivo function was evaluated after transplant under the kidney capsule of diabetic immunodeficient mice. Graft morphology and vascularization were evaluated by immunohistochemistry. Both shielded RIs and HIs show higher viability and increased glucose‐stimulated insulin secretion after exposure to hypoxia in vitro compared with control islets. Transplant of shielded islets results in considerably earlier normoglycemia and vascularization, an enhanced glucose tolerance, and a higher β cell mass. Our results show that hAECs have a clear cytoprotective effect against hypoxic damages in vitro. This strategy improves β cell mass engraftment and islet revascularization, leading to an improved capacity of islets to reverse hyperglycemia, and could be rapidly applicable in the clinical situation seeing that the modification to HIs are minor. 相似文献
49.
50.
SJ Smith CV Rahman PA Clarke AA Ritchie TW Gould JH Ward KM Shakesheff RG Grundy R Rahman 《Annals of the Royal College of Surgeons of England》2014,96(7):495-501