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81.
82.
ZALIN AM; JONES S; FITCH NJS; RAMSDEN DB 《QJM : monthly journal of the Association of Physicians》1991,81(2):945-956
Classification of familial amyloidosis by the chemical natureof the fibrillar protein has become possible. Most such amyloidogenicproteins so far recognized are variant transthyretins, but twokindreds with the same apolipoprotein AI modification have beenreported. We describe the clinical features of another suchfamily in whom petechial skin rash appeared to be a marker forthe disease, which was non-neuropathic and of the Ostertag-type.Immunohistochemistry showed the protein to be apolipoproteinAI, but allele-specific DNA amplification indicated that itwas not the Arg26 variant previously identified. 相似文献
83.
RI Shopnick ; M Kazemi ; DB Brettler ; C Buckwalter ; L Yang ; G Bray ; ED Gomperts 《Transfusion》1996,36(4):358-361
BACKGROUND: Treatment of hemophilia patients with recombinant factor VIII concentrates has not previously been associated with anaphylaxis. STUDY DESIGN AND METHODS: A 5-week-old boy with severe hemophilia A developed dyspnea, cyanosis, hypotension, and a diffuse urticarial rash following treatment with a recombinant factor VIII (Recombinate). To identify the cause of anaphylaxis in this patient, the vial lot was examined for the presence of endotoxin, and a checkerboard immunoblotting technique was used to test serum and/or plasma samples from the patient and mother for the presence of antibodies (IgA, IgG, IgE, and IgM) to Recombinate-related antigens (recombinant factor VIII, von Willebrand factor, human serum albumin, Chinese hamster ovary proteins, bovine serum albumin, mouse monoclonal anti-human factor VIII, polyethylene glycol 3350), and to ethylene oxide, the agent used to sterilize the infusion equipment. RESULTS: No immune response directed against the Recombinate-related antigens or ethylene oxide that could be associated with the anaphylactic reaction was identified. Endotoxin was not present upon rabbit pyrogen testing of the therapeutic product. CONCLUSION: These studies failed to show any association between Recombinate and the onset of the allergic reaction. This seems to be the first reported case of anaphylaxis following the infusion of a recombinant form of factor VIII concentrate. 相似文献
84.
Discrepancies in reverse ABO typing due to prozone 总被引:5,自引:0,他引:5
Three group O sera manifesting prozone in reverse ABO tests are reported. All were implicated in erroneous blood typing results. One sample failed to react with A1 red cells (RBCs) in immediate-spin (IS) tests, had anti-A and -B titers of 8192 and 2048, respectively, by indirect antiglobulin technique (IAT), and was from a diabetic patient; the parenteral administration of A substance present in porcine insulin is a possible cause of hyperimmunity in this case. The second sample was from the recipient of a single unit of group B fresh-frozen plasma; the serum anti-A and -B titers were 10,240 by IAT, but only weak reactions with A1 and B RBCs were noted in routine IS reverse typing tests; the hyperimmunity in the patient concerned was likely due to crossreacting anti-A, B stimulated by B-active glycoproteins and/or glycolipids in the transfused plasma. The third serum also had anti-A and anti-B IAT titers of 10,240 but did not react with A1 and B RBCs by IS; the hyperimmunity in this case may be related to sepsis from intestinal flora carrying A- and/or B-like antigens. These antibodies lysed A1 and/or B RBCs in tests incubated at room temperature (RT) and strongly agglutinated those RBCs by IS when diluted 10-fold with saline. The absence of the prozone phenomenon in tests with RBCs suspended in diluents containing EDTA is consistent with the previously published mechanism for anti-A prozone: namely, the steric hindrance of agglutination by the C1 component of human complement.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
85.
In 93 patients who underwent percutaneous transhepatic portography an arteriography of the liver was performed. In 8 cases intrahepatic arterioportal fistulas of iatrogenic descent were found. All 8 patients suffered from liver cirrhosis. There were no remarkable clinical symptoms. Artificial arterioportal fistulas showed a tendency spontaneous occlusion. For their detection the length of the interval between percutaneous transhepatic portography and hepatic arteriography is important. In 7 patients with iatrogenic arterioportal fistulas an embolization of the trunk or the right liver artery was carried out. This therapy turned out to be effective. 相似文献
86.
Karas'kov AM Mukhoedova TV Lomivorotov VN Malov AA Legan MV Semenov II Kolesnikov SV Borisov AS 《Anesteziologiia i reanimatologiia》2002,(2):54-57
The efficiency of plasmapheresis in the treatment of infectious complications and multiple organ dysfunctions was evaluated in 66 patients after heart surgery. Early plasmapheresis attenuated the cytokine-related systemic inflammatory response and organ damage. The optimal use of plasmapheresis modifications (membrane plasma filtration, plasma carboperfusion, cryoapheresis) improved the clinical outcomes. 相似文献
87.
88.
Borisov AE Tvorogov DA Veselov IuE Zarkua NE 《Vestnik khirurgii imeni I. I. Grekova》2010,169(6):64-68
An experience with different approaches to treatment of acute cholecystitis under conditions of multifield hospitals is described. On the basis of comparative data of treatment of 10518 patients the optimal strategy of treatment of acute cholecystitis was determined. 相似文献
89.
90.
CE Vitor CP Figueiredo DB Hara AF Bento TL Mazzuco JB Calixto 《British journal of pharmacology》2009,157(6):1034-1044