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51.
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NJ Gogtay KD Kamtekar SS Dalvi SS Mehta AR Chogle U Aigal NA Kshirsagar 《BMC infectious diseases》2006,6(1):16-4
Background
The WHO recommends that adults with uncomplicated P. falciparum successfully treated with a blood schizonticide receive a single dose of primaquine (PQ) 45 mg as a gametocytocidal agent. An earlier pilot study suggested that 75 mg of bulaquine (BQ), of which PQ is a major metabolite, may be a useful alternate to PQ. 相似文献53.
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Montori VM Dinneen SF Gorman CA Zimmerman BR Rizza RA Bjornsen SS Green EM Bryant SC Smith SA;Translation Project Investigator Group 《Diabetes care》2002,25(11):1952-1957
OBJECTIVE: The Mayo Health System Diabetes Translation Project sought to assess models of community-based diabetes care and use of a diabetes electronic management system (DEMS). Planned care is a redesigned model of chronic disease care that involves guideline implementation, support of self-management, and use of clinical information systems. RESEARCH DESIGN AND METHODS:We studied adult diabetic patients attending three primary care practice sites in Wisconsin and Minnesota. We implemented planned care at all sites and DEMS in the practice of 16 primary care providers. We assessed quality of diabetes care using standard indicators for 200 patients randomly selected from each site at baseline and at 24 months of implementation. We used multivariable analyses to estimate the association between planned care and DEMS and each quality indicator. RESULTS: Planned care was associated with improvements in measurement of HbA(1c) (odds ratio 7.0 [95% CI 4.2-11.6]), HDL cholesterol (5.6 [4.1-7.5]), and microalbuminuria (5.3 [3.5-8.0]), as well as the provision of tobacco advice (6.9 [4.7-10.1]), among other performance measures. DEMS use was associated with improvements in all indicators, including microalbuminuria (3.2 [1.9-5.2]), retinal examination (2.4 [1.5-3.9]), foot examinations (2.3 [1.2-4.4]), and self-management support (2.6 [1.7-3.8]). Although planned care was associated with improvements in metabolic control, we observed no additional metabolic benefit when providers used DEMS. CONCLUSIONS: Planned care was associated with improved performance and metabolic outcomes in primary care. DEMS use augmented the impact of planned care on performance outcomes but not on metabolic outcomes. Optimal identification of the best translation of evidence to diabetes practice will require longer follow-up or new care-delivery models. 相似文献
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Strom TM; Hortnagel K; Hofmann S; Gekeler F; Scharfe C; Rabl W; Gerbitz KD; Meitinger T 《Human molecular genetics》1998,7(13):2021-2028
Wolfram syndrome is an autosomal recessive disorder characterized by
juvenile diabetes mellitus, diabetes insipidus, optic atrophy and a number
of neurological symptoms including deafness, ataxia and peripheral
neuropathy. Mitochondrial DNA deletions have been described in a few
patients and a locus has been mapped to 4p16 by linkage analysis.
Susceptibility to psychiatric illness is reported to be high in affected
individuals and increased in heterozygous carriers in Wolfram syndrome
families. We screened four candidate genes in a refined critical linkage
interval covered by an unfinished genomic sequence of 600 kb. One of these
genes, subsequently named wolframin, codes for a predicted transmembrane
protein which was expressed in various tissues, including brain and
pancreas, and carried loss-of- function mutations in both alleles in
Wolfram syndrome patients.
相似文献
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59.
Suppression of peroxisomal membrane protein defects by peroxisomal ATP binding cassette (ABC) proteins 总被引:8,自引:4,他引:4
Braiterman LT; Zheng S; Watkins PA; Geraghty MT; Johnson G; McGuinness MC; Moser AB; Smith KD 《Human molecular genetics》1998,7(2):239-247
X-Linked adrenoleukodystrophy (X-ALD) is a neurodegenerative disorder
characterized by reduced peroxisomal very long chain fatty acid (VLCFA)
beta-oxidation. The X - ALD gene product (ALDP) is a peroxisomal
transmembrane protein with an ATP binding cassette (ABC). ALDP and three
other ABC proteins (PMP70, ALDR, P70R) localize to the peroxisomal
membrane. The function of this family of peroxisomal membrane proteins is
unknown. We used complementation studies to begin analysis of their role in
VLCFA beta-oxidation and on the peroxisomal membrane. Expression of either
ALDP or PMP70 restores VLCFA beta- oxidation in X-ALD fibroblasts,
indicating overlapping functions. Their expression also restores peroxisome
biogenesis in cells that are deficient in the peroxisomal membrane protein
Pex2p. Thus it is likely that complex protein interactions are involved in
the function and biogenesis of peroxisomal membranes that may contribute to
disease heterogeneity.
相似文献
60.
Steinsapir KD Goldberg RA Sinha S Hovda DA 《Journal of the peripheral nervous system : JPNS》2002,7(2):136-136
The excitability of human axons can be studied reliably using the technique of threshold tracking, which allows the strength of a test stimulus to be adjusted by computer to activate a defined fraction of the maximal nerve or muscle action potential. The stimulus current that just evokes the target response is considered the 'threshold' for that response. More useful than the resting threshold are other indices of axonal excitability derived from pairs of threshold measurements, such as refractoriness, supernormality, strength-duration time constant and 'threshold electrotonus' (i.e. the changes in threshold produced by long-lasting depolarizing or hyperpolarizing current pulses). Each of these measurements depends on membrane potential and on other biophysical properties of the axons. Together they can provide new information about the pathophysiology underlying abnormalities in excitability in neuropathy. 相似文献