Decrease in brain serotonin level and short term memory loss in mice: a preliminary study

Most of the information on the effects of benzene center around its hematotoxic and genotoxic effects. However, its effect on central neurotransmitters is inconclusive in terms of cognitive behavior of the host. The present results showed for the first time that chronic exposure to benzene, in drinking water, significantly inhibited serotonin (5-hydroxytryptamine (5-HT)) level in serotonergic neuron rich regions of the murine brain. This was paralleled with loss of short term memory, as evidenced by passive avoidance test, of the benzene treated animals.     

Moyamoya syndrome in a child with Down syndrome

Moyamoya syndrome has rarely been reported in association with Down syndrome. We report a case of an 11-year-old female child with Down syndrome who presented with hemiparesis and facial palsy. Imaging investigations (magnetic resonance angiography and digital subtraction angiography) revealed the classical Moyamoya pattern. Work-up for prothrombotic and autoimmune disorders was negative. The neurological deficits recovered well. The association of Moyamoya syndrome in patients with Down syndrome has been highlighted. The possible causes for the association and management have been reviewed briefly.     

A clinico epidemiological study on acute viral infection of brain among children admitted in North Bengal Medical College, West Bengal

A clinico epidemiological prospective study was carried out on acute viral infection of brain among children admitted in a rural based medical college from September '99 to Oct '01. Out of 80 cases, 8 cases (10%) of aseptic meningitis, 35 cases (43.75%) of encephalitis and 37 cases (6.25%) of meningo-encephalitis were found. Overall case fatality was 47.5% and found higher (77%) among normally nourished children in comparison to malnourished children (47.5%). Virological investigation did not isolate any known Flavivirus, Herpes Simplex virus (HSV) and Measles virus; nor any serological evidence against these viruses.     

A study on bed utilization in the gynaecological ward of a district hospital in West Bengal

A study was conducted in a non-paying gynaecological ward of the district hospital, South 24 Parganas, West Bengal to assess different bed efficiency indicators. Total 331 patients were admitted in 23 study beds (12 OPD beds and 11 emergency beds) during an observation period of six months. Overall average number of admissions were 14.4 and average length of stay 14.7days. Bed turnover rate was 13.8 and was higher for emergency beds (22.1) compared to OPD beds (9). Bed occupancy rate was 61.3% with significant difference between OPD beds (57.5%) and emergency beds (65.4%).     

Neurobiological evidence for abstract phonological representations in the mental lexicon during speech recognition

A central issue in speech recognition is how contrastive phonemic information is stored in the mental lexicon. The conventional view assumes that this information is closely related to acoustic properties of speech. Considering that no world is ever pronounced alike twice and that the brain has limited capacities to manage information, an opposing view proposes abstract underspecified representations where not all phonemic features are stored. We examined this propos.al using event-related brain potentials, in particular mismatch negativity (MMN), an automatic change detection response in the brain that is sensitive to language-specific phoneme representations. In the current study, vowel pairs were presented to subjects, reversed as standard and deviant. Models not assuming underspecification predict equal MMNsfor vowel pairs regardless of the reversal. In contrast, enhanced and earlier MMNs were observed for those conditions where the standard is not phonologically underspecified in the mental representation. This provides the first neuro-biological evidence for a featurally underspecified mental lexicon.