全文获取类型
收费全文 | 138篇 |
免费 | 7篇 |
专业分类
儿科学 | 9篇 |
妇产科学 | 2篇 |
基础医学 | 5篇 |
口腔科学 | 1篇 |
临床医学 | 48篇 |
内科学 | 33篇 |
皮肤病学 | 2篇 |
神经病学 | 5篇 |
特种医学 | 9篇 |
外科学 | 9篇 |
综合类 | 3篇 |
预防医学 | 1篇 |
眼科学 | 1篇 |
药学 | 15篇 |
肿瘤学 | 2篇 |
出版年
2023年 | 2篇 |
2022年 | 3篇 |
2021年 | 4篇 |
2020年 | 4篇 |
2019年 | 6篇 |
2018年 | 8篇 |
2017年 | 1篇 |
2015年 | 1篇 |
2014年 | 2篇 |
2013年 | 5篇 |
2012年 | 14篇 |
2011年 | 8篇 |
2010年 | 4篇 |
2009年 | 1篇 |
2008年 | 8篇 |
2007年 | 9篇 |
2006年 | 10篇 |
2005年 | 5篇 |
2004年 | 7篇 |
2003年 | 14篇 |
2002年 | 3篇 |
2001年 | 3篇 |
2000年 | 1篇 |
1999年 | 2篇 |
1998年 | 1篇 |
1996年 | 3篇 |
1991年 | 3篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1983年 | 1篇 |
1979年 | 2篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1972年 | 1篇 |
1969年 | 1篇 |
1966年 | 2篇 |
排序方式: 共有145条查询结果,搜索用时 15 毫秒
41.
42.
James S. Ware Almudena Amor-Salamanca Upasana Tayal Risha Govind Isabel Serrano Joel Salazar-Mendiguchía Jose Manuel García-Pinilla Domingo A. Pascual-Figal Julio Nuñez Gonzalo Guzzo-Merello Emiliano Gonzalez-Vioque Alfredo Bardaji Nicolas Manito Miguel A. López-Garrido Laura Padron-Barthe Elizabeth Edwards Nicola Whiffin Roddy Walsh Pablo Garcia-Pavia 《Journal of the American College of Cardiology》2018,71(20):2293-2302
Background
Alcoholic cardiomyopathy (ACM) is defined by a dilated and impaired left ventricle due to chronic excess alcohol consumption. It is largely unknown which factors determine cardiac toxicity on exposure to alcohol.Objectives
This study sought to evaluate the role of variation in cardiomyopathy-associated genes in the pathophysiology of ACM, and to examine the effects of alcohol intake and genotype on dilated cardiomyopathy (DCM) severity.Methods
The authors characterized 141 ACM cases, 716 DCM cases, and 445 healthy volunteers. The authors compared the prevalence of rare, protein-altering variants in 9 genes associated with inherited DCM. They evaluated the effect of genotype and alcohol consumption on phenotype in DCM.Results
Variants in well-characterized DCM-causing genes were more prevalent in patients with ACM than control subjects (13.5% vs. 2.9%; p = 1.2 ×10?5), but similar between patients with ACM and DCM (19.4%; p = 0.12) and with a predominant burden of titin truncating variants (TTNtv) (9.9%). Separately, we identified an interaction between TTN genotype and excess alcohol consumption in a cohort of DCM patients not meeting ACM criteria. On multivariate analysis, DCM patients with a TTNtv who consumed excess alcohol had an 8.7% absolute reduction in ejection fraction (95% confidence interval: ?2.3% to ?15.1%; p < 0.007) compared with those without TTNtv and excess alcohol consumption. The presence of TTNtv did not predict phenotype, outcome, or functional recovery on treatment in ACM patients.Conclusions
TTNtv represent a prevalent genetic predisposition for ACM, and are also associated with a worse left ventricular ejection fraction in DCM patients who consume alcohol above recommended levels. Familial evaluation and genetic testing should be considered in patients presenting with ACM. 相似文献43.
44.
45.
Chulho Song Okkyun Seo Daiju Matsumura Satoshi Hiroi Yi-Tao Cui Jaemyung Kim Yanna Chen Akhil Tayal Kohei Kusada Hirokazu Kobayashi Hiroshi Kitagawa Osami Sakata 《RSC advances》2020,10(34):19751
To unveil the origin of the hydrogen-storage properties of rhodium nanoparticles (Rh NPs), we investigated the dynamical structural change of Rh NPs using in situ dispersive X-ray absorption fine structure spectroscopy (XAFS). The variation of the Rh–Rh interatomic distance and Debye–Waller factor of Rh NPs with a size of 4.0 and 10.5 nm during hydrogen absorption and desorption suggested that they have a different mechanism for hydrogen absorption, which is that the hydrogen absorption on the inner site has a greater contribution than that on a surface for Rh 4.0 nm. In the case of Rh 10.5 nm, it is opposed to Rh 4.0 nm. This study demonstrates a powerful in situ XAFS method for observing small local structural changes of metal nanoparticles and its importance for understanding of the hydrogen-absorption properties of Rh NPs with an interesting hydrogenation mechanism.To unveil the origin of the hydrogen-storage properties of rhodium nanoparticles (Rh NPs), we investigated the dynamical structural change of Rh NPs using in situ dispersive X-ray absorption fine structure spectroscopy (XAFS). 相似文献
46.
Tiwari AK Agrawal J Tayal S Chadha M Singla A Valson G Tomar GS 《Annals of cardiac anaesthesia》2012,15(1):44-46
Peripartum cardiomyopathy is a rare cause of dilated cardiomyopathy in parturients, occurring in approximately one in 1000 deliveries, manifesting during the last few months or the first 5 months of the postpartum period. It can result in severe ventricular dysfunction during late puerperium. The major concern while managing these patients is to optimize fluid administration and avoid myocardial depression, while maintaining stable intraoperative hemodynamics. We present a case series of five parturients that were posted for elective cesarean section and managed successfully by the epidural volume extension technique. 相似文献
47.
Introduction
Coronary artery disease (CAD) is emerging as the biggest killer of the 21st century. A number of theories have been postulated to explain the aetiology of atherosclerosis. The present study attempts to elucidate the interaction, if any, between inflammation, oxidative stress and dyslipidaemia in CAD.Methods
A total of 753 patients undergoing angiography were evaluated and 476 were included in the study. The parameters studied included complete lipid profile, and apolipoprotein B, ferritin and nitric oxide (NO) levels. Statistical analysis was carried out to determine the interrelationship between these parameters and the best predictor of CAD risk. Cut-off points were determined from the receiver operating characteristics curves, and the specificity, sensitivity, positive predictive value, negative predictive value, odds ratio and confidence intervals were calculated.Results
The levels of the parameters studied increased with the stenotic state and a positive correlation was observed between ferritin, NO and apolipoprotein B. NO emerged as the most reliable predictor of CAD, with an area under the curve of 0.992 and sensitivity and specificity of 97 and 98%, respectively.Conclusion
Environmental and genetic risk factors for CAD interact in a highly complex manner to initiate the atherosclerotic process. These risk factors should be considered mutually inclusive, not exclusive when devising pharmacological interventions, as multi-factorial risk management is the cornerstone of CAD management 相似文献48.
49.
50.
Resa E. Lewiss MD Vivek S. Tayal MD Beatrice Hoffmann MD PhD John Kendall MD Andrew S. Liteplo MD James H. Moak MD Nova Panebianco MD MPH Vicki E. Noble MD 《Academic emergency medicine》2014,21(4):456-461
The purpose of developing a core content for subspecialty training in clinical ultrasonography (US) is to standardize the education and qualifications required to provide oversight of US training, clinical use, and administration to improve patient care. This core content would be mastered by a fellow as a separate and unique postgraduate training, beyond that obtained during an emergency medicine (EM) residency or during medical school. The core content defines the training parameters, resources, and knowledge of clinical US necessary to direct clinical US divisions within medical specialties. Additionally, it is intended to inform fellowship directors and candidates for certification of the full range of content that might appear in future examinations. This article describes the development of the core content and presents the core content in its entirety. 相似文献