Magnetic resonance appearance of posterosuperior labral peel back during humeral abduction and external rotation

Objective  

To describe the magnetic resonance appearance of posterosuperior labral peel back and determine the reliability of MR in the abducted and externally rotated (ABER) position for the prospective diagnosis of arthroscopically proven cases of posterosuperior labral peel back.     

Attention to novelty in behaviorally inhibited adolescents moderates risk for anxiety

Background:  Individual differences in specific components of attention contribute to behavioral reactivity and regulation. Children with the temperament of behavioral inhibition (BI) provide a good context for considering the manner in which certain components of attention shape behavior. Infants and children characterized as behaviorally inhibited manifest signs of heightened orienting to novelty. The current study considers whether this attention profile moderates risk for clinical anxiety disorders among adolescents with a history of BI.
Methods:  Participants were assessed at multiple time points for BI, beginning in early childhood. At adolescence, event-related potentials (ERPs) were recorded during a three-stimulus auditory novelty oddball task, which employed frequent standard and infrequent deviant tones as well as a set of complex, novel sounds. Clinical diagnosis was carried out using the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL). P3 and mismatch negativity (MMN) components were examined at midline frontal, central, and parietal electrode sites.
Results:  Individuals who displayed high levels of BI during childhood and increased P3 amplitude to novelty in adolescence were more likely to have a history of anxiety disorders compared to behaviorally inhibited adolescents with lower P3 amplitudes. Groups did not differ on measures of MMN.
Conclusions:  Increased neural responses to novelty moderate risk for anxiety disorders amongst individuals with a history of BI.     

Evaluation of the Food And Nutrient Database for Dietary Studies for use with a mobile telephone food record

The development of a mobile telephone food record (mpFR) in which image analysis and volume estimation data can be indexed with the Food and Nutrient Database for Dietary Studies (FNDDS) has the potential to improve the accuracy of dietary assessment. To validate the mpFR for use with adolescents, a convenience sample of adolescents, aged 11–18 years, was recruited to eat all meals and snacks in a controlled feeding environment over a 24-h period. Each food item matched a food code in the FNDDS 3.0. The objective of this analysis was to compare the measured energy and protein content of foods to the published values in the FNDDS. Duplicate plates of all meals and snacks were prepared, and samples of 20 foods were individually weighed, homogenized, freeze dried, and analyzed for energy with a bomb calorimeter and for protein with a Dumas nitrogen analyzer. Eleven of the twenty food items had energy values in the FNDDS within ±10% of the measured energy value. The measured energy and protein values from all foods correlated significantly with the energy (r = 0.981, P < 0.01) and protein (r = 0.911, P < 0.01) values in the FNDDS. These results support the use of the FNDDS with the mpFR.     

Using Sibling Differences to Estimate Effects of Parenting on Adolescent Sexual Risk Behaviors

PURPOSE: To estimate effects of positive and involved parenting during mid-adolescence on sexual risk behaviors (frequency of intercourse, unprotected intercourse, and number of sexual partners) during late adolescence. Substantial literature suggests that supportive family contexts and parenting behaviors may discourage adolescents from engaging in early and risky sexual activities; yet methodological limitations hamper the conclusions regarding causality and directionality that can be drawn from much existing research. To address such limitations, the current study used a variety of increasingly conservative statistical modeling techniques to help control for unobserved heterogeneity and potential bias and hence to progress toward identifying causal relationships. METHODS: Drawing from a nationally representative longitudinal survey of adolescents (NLSY97; N = 4980), this study used ordinary least squares (OLS) regression models, lagged regression models, and family fixed-effects models to assess whether parental knowledge, parent negativity, and family activities during midadolescence predicted differences in late adolescent sexual risk behaviors. RESULTS: Even after controlling for unobserved heterogeneity across individuals and across families, parenting processes significantly predicted later adolescent sexual risk behaviors. Specifically, more regular family activities and less negative and hostile parenting during mid-adolescence predicted lower sexual risk behaviors during late adolescence. CONCLUSIONS: Results concerning the buffering effects of parenting on adolescent risk behaviors help to inform prevention and intervention efforts. Through the use of more rigorous statistical methodology and large representative samples of youth, this research provides an exemplar of how survey research can seek to move closer to understanding causal processes in the exceedingly complex systems of human development.     

Magical beliefs and rituals in young children

Thirty-one children were administered a structured interview that assessed their beliefs about magic, tricks and wishes. Children were also presented with demonstrations of magic tricks/illusions, and asked to offer explanations as to how they worked. Parents completed the Childhood Routines Inventory (CRI), a 19-item parent report measure that assesses children's rituals, habits and sensory-perceptual experiences that we have termed compulsive-like behavior. Results indicated that children's rituals and compulsions were positively related to their magical beliefs, and inversely related to their uses of concrete, physical explanations to describe various phenomena. In particular, children's beliefs about the effects of wishing were most consistently correlated with their compulsive-like rituals and routines. The findings extended the work on magical beliefs and obsessive-compulsive phenomena to the normative manifestation of compulsive behaviors found in typical development.     

The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours

The aim of this study was to determine how the efficacy of tamoxifen is affected when combined with soy isoflavones. To address this, female Sprague-Dawley rats were placed on diets supplemented with tamoxifen, genistein, daidzein, or a combination of each isoflavone with tamoxifen; a week later mammary tumours were induced by 7,12 dimethylbenzanthracene. The most effective diet was the tamoxifen/daidzein combination. It reduced tumour multiplicity by 76%, tumour incidence by 35%, tumour burden by over 95%, and increased tumour latency by 62% compared with positive controls. The tamoxifen/daidzein combination diet was in all aspects more effective while the tamoxifen/genistein combination was less effective than the tamoxifen diet. The tamoxifen/daidzein diet significantly decreased 8-oxo-deoxyguanosine levels (an indicator of oxidative DNA damage) in the mammary glands. This study conclusively shows for the first time the combination of daidzein with tamoxifen produces increased protection against mammary carcinogenesis, while the combination of genistein with tamoxifen produces an opposing effect when compared with tamoxifen alone.     

Safety and cost benefits of bilateral total knee replacement in an acute hospital

BACKGROUND: Total knee arthroplasty of both knees under the one anaesthetic has become a common procedure. Benefits reported include a shorter overall hospital stay and reduced costs. The published studies come from university associated tertiary referral hospitals with well-established research establishments and a vast experience of joint replacement. This study examines the experience of a small hospital to see if similar benefits can be achieved. METHODS: A retrospective medical record review was performed of the synchronous bilateral knee replacements against a match group of bilateral staged knee replacements. Both groups were compared with a control group of unilateral knee replacements. A prospectively conducted review of the synchronous and staged bilateral knee replacement groups was then carried out to assess the clinical outcome in these two groups. RESULTS: The incidence of surgical and medical complications was not statistically different in any group. The bed stay for bilateral surgery was increased by 2 days compared to unilateral surgery with a net saving of 6 days hospital stay for the patient group having both knees replaced at separate operations within 1 year. At an average of 2.5 years post surgery there was no statistically significant difference in outcome between those patients who had both knees replaced either synchronously or at staged intervals. CONCLUSIONS: Bilateral knee replacement is a good choice for patient and hospital. Bilateral surgery does not increase the risk of perioperative complications to the patient and reduces the overall cost to the hospital. There is no difference in short to medium term clinical outcome between patients who have had both knees replaced synchronously or at staged intervals. Results comparable in safety, as judged by complication rates and efficiency, as judged by length of stay can be achieved in a smaller metropolitan level 2 hospital environment.     

Body weight-supported treadmill training versus conventional gait training for people with chronic traumatic brain injury

OBJECTIVES: To compare body weight support treadmill training (BWSTT) to conventional overground gait training (COGT). DESIGN: Randomized controlled trial. SETTING: Residential rehabilitation center. PARTICIPANTS: Twenty subjects with chronic traumatic brain injury (TBI). INTERVENTION: The BWSTT or COGT for 15 minutes plus 30 minutes of exercise 2 days per week, for 3 months. MAIN OUTCOME MEASURES: Functional Ambulation Category (FAC), Functional Reach (FR), Timed Up and Go; gait velocity, step width (BOS) and step length differential using instrumented gait mat. RESULTS: Step width approached the norm without between-group differences. Step length differential improved significantly more for the COGT. CONCLUSIONS: Physical therapy can improve gait for patients more than 6 years post-TBI. The COGT is more effective than the BWSTT for improving gait symmetry during overground walking.