全文获取类型
收费全文 | 2425篇 |
免费 | 111篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 59篇 |
儿科学 | 140篇 |
妇产科学 | 343篇 |
基础医学 | 185篇 |
口腔科学 | 72篇 |
临床医学 | 216篇 |
内科学 | 432篇 |
皮肤病学 | 22篇 |
神经病学 | 76篇 |
特种医学 | 292篇 |
外科学 | 217篇 |
综合类 | 35篇 |
一般理论 | 2篇 |
预防医学 | 186篇 |
眼科学 | 59篇 |
药学 | 96篇 |
1篇 | |
中国医学 | 9篇 |
肿瘤学 | 99篇 |
出版年
2021年 | 22篇 |
2020年 | 16篇 |
2018年 | 28篇 |
2017年 | 14篇 |
2016年 | 20篇 |
2015年 | 29篇 |
2014年 | 33篇 |
2013年 | 47篇 |
2012年 | 63篇 |
2011年 | 76篇 |
2010年 | 68篇 |
2009年 | 52篇 |
2008年 | 67篇 |
2007年 | 82篇 |
2006年 | 101篇 |
2005年 | 94篇 |
2004年 | 77篇 |
2003年 | 73篇 |
2002年 | 60篇 |
2001年 | 72篇 |
2000年 | 68篇 |
1999年 | 68篇 |
1998年 | 41篇 |
1997年 | 46篇 |
1996年 | 44篇 |
1995年 | 60篇 |
1994年 | 47篇 |
1993年 | 47篇 |
1992年 | 54篇 |
1991年 | 47篇 |
1990年 | 63篇 |
1989年 | 78篇 |
1988年 | 68篇 |
1987年 | 76篇 |
1986年 | 83篇 |
1985年 | 73篇 |
1984年 | 56篇 |
1983年 | 38篇 |
1982年 | 36篇 |
1981年 | 36篇 |
1980年 | 34篇 |
1979年 | 39篇 |
1978年 | 32篇 |
1977年 | 31篇 |
1976年 | 28篇 |
1975年 | 25篇 |
1974年 | 17篇 |
1971年 | 15篇 |
1970年 | 12篇 |
1969年 | 11篇 |
排序方式: 共有2541条查询结果,搜索用时 15 毫秒
41.
OBJECTIVES: To investigate maternal knowledge and attitudes about otitis media (OM) risk, to estimate the prevalence of risk factors in the first year of life, and to identify barriers to the reduction of risk factors (eg, formula feeding, day care attendance, and exposure to passive smoke). METHODS: Questionnaires mailed to a systematic sample of 504 Minnesota women >/=18 years old identified through 1994 birth certificates. RESULTS: Eighty percent returned a completed survey. According to maternal report, 29% of infants (age 8 to 13 months) had recurrent OM (>/=3 episodes) and 2% had tympanostomy tubes. Forty-six percent attended day care, 29% had >/=1 smoking parent, and 49% breastfed for =2 months. Women were more knowledgeable about OM signs and symptoms than about risk factors. Mean OM knowledge score (the sum of correct true-false responses) was 7.0 (standard deviation = 1.6). Using multiple linear regression, knowledge score was significantly related to marital status, education, age, area of residence, breastfeeding (months), and number of cigarettes smoked per day by the mother, but not to infant or sibling OM history or day care attendance (R = .23). Infant history of OM (odds ratio, 1.9; 95% confidence interval, 1.1 to 3.2) and white race (odds ratio, 0.3; 95% confidence interval, 0. 1 to 0.8), but not the presence of risk factors, were significantly related to having received clinicians' advice about OM prevention advice. CONCLUSION: OM education and prevention programs should target pregnant women and new mothers with OM risk factors, and those who are young, single, and less educated. 相似文献
42.
Hansen LA; Malarkey DE; Wilkinson JE; Rosenberg M; Woychik RE; Tennant RW 《Carcinogenesis》1998,19(10):1837-1845
We previously reported that papillomas can arise from the follicular
epithelium of v-Ha-ras transgenic TGxAC mice. Since the viable-yellow
mutation (A(vy)) of the mouse agouti gene which regulates coat color
pigmentation by acting within the micro-environment of the hair follicle
has been shown to function as a tumor promoter in the liver, we
hypothesized that it may also play a role in TGxAC skin tumorigenesis.
Endogenous agouti protein product was detected in the outer root sheath of
anagen hair follicles following plucking of the hair shaft, but not in the
interfollicular epithelium, in TGxAC mice on an FVB/N genetic background.
It was also detected in papillomas from these mice produced by
12-O-tetradecanoylphorbol-13-acetate (TPA) treatment or plucking.
Expression of the A(vy) allele in the v-Ha-ras transgenic TGxAC mouse line
results in an approximately 2-fold increase in papilloma development
compared with controls which did not carry the A(vy) allele following
twice-weekly treatment with 1.25, 2.5 or 5.0 microg TPA. In addition,
TPA-treated, papilloma-bearing F1 mice which carried the A(vy) allele, but
not F1 mice which did not carry the A(vy) allele, exhibited a syndrome of
humoral hypercalcemia mediated by parathyroid hormone-related protein
(PTHrP) that led to weight loss, hypercalcemia and hypophosphatemia. Thus,
we conclude that the A(vy) allele can influence the development of skin
tumors and PTHrP-mediated humoral hypercalcemia in v-Ha-ras transgenic
TGxAC mice.
相似文献
43.
44.
The anterosuperior rotator interval portal for SLAP repair anchor placement is the perfect balance between obtaining the proper anchor trajectory and respecting the rotator cuff integrity. 相似文献
45.
Chest pain and shortness of breath are both common complaints of patients presenting to an emergency room (ER) or urgent care facility. A 67-year-old married white female was seen in the ER complaining of chest pain and shortness of breath. Our education and training has us admit these patients where they may be monitored and assessed according to protocols developed to rule-out serious etiologies. Accordingly, the patient was admitted to the cardiac care unit and placed on the “Rule-Out Myocardial Infarction” protocol. The patient’s symptoms persisted despite adherence to rigorous diagnostic and therapeutic regimens and which stymied attempts to arrive at a definitive diagnosis and provide care. The case presented here demonstrates how an osteopathic approach can enable us to provide appropriate care and resolve some problems that appear to be otherwise unremitting. There is potential for savings in terms of actual costs and utilization of resources. The use of an osteopathic structural exam identified an abnormality that could be easily treated with Osteopathic Manipulative Treatment (OMT), which completely resolved the patient’s presenting complaints. Had this been done earlier in the course of managing this patient, preferably as part of the admission work-up, the patient’s confinement would have been drastically reduced, and repeated expensive tests would not have had to have been performed. The application of OMT to reducing patient morbidity is instructive of the efficacy of the osteopathic approach in this case and suggests that further research is warranted. 相似文献
46.
有越来越多的医生选择学习在线课程来进行继续医学教育,但却很少有严格的评估方法来确定在线继续医学教育活动的效果.鉴于此,美国阿拉巴马大学医学院继续医学教育部的研究人员进行了相关研究.应用时间序列设计的方法,来比较完成了继续医学教育网站提供的任意30分钟在线继续医学教育课程的医生在教育活动前后其知识、态度和自我报告的在临床实践中诊疗行为的变化. 相似文献
47.
Surgery for third degree rectal prolapse and its sequelae in the elderly still represents a challenge. We report the case of a 92-year-old patient with a history of recurrent third degree rectal prolapse of at least 2?years?? standing. The patient had already had abdominal rectopexy for the same disease 16 years previously. In addition, she now suffered a large perianal ulcer. The patient underwent abdominal rectopexy and biopsy from the ulcer. The histology from the ulcer margin revealed a squamous cell anal cancer. In conclusion, we postulate that the anal cancer can be considered as a consequence of the long-standing rectal prolapse. The patient had previously been informed by her family practitioner that the prolapse could not be operated due to her advanced age. This case highlights that a third degree rectal prolapse should be operated regardless of age in order to avoid late sequelae. 相似文献
48.
Adenosine bronchial provocation with computerized wheeze detection in young infants with prolonged cough: correlation with long-term follow-up 总被引:1,自引:0,他引:1
BACKGROUND: Chronic cough in babies is often associated with bronchial hyperreactivity (BHR). The objective documentation of BHR in babies is difficult, and acoustic methods have been described (provocative concentration of a substance causing wheeze) for conducting bronchial provocation tests (BPTs). We conducted a study to evaluate automatic computerized wheeze detection (CWD) in determining BHR in young infants with prolonged cough, and its correlation with the subsequent development of wheezing. METHODS: Infants aged < 24 months with prolonged cough (ie, > 2 months) underwent acoustic BPTs with the response determined by CWD and auscultation by a physician. Telephone interviews with parents were conducted after 1 month and yearly for the next 3 years. RESULTS: A total of 28 infants who were 4 to 24 months old with prolonged cough were included in the study. Twenty of these infants (71.4%) had BHR as determined by a positive acoustic BPT result. In 11 of these 20 tests, the CWD occurred earlier, and in 9 tests it occurred at the same step as auscultation by a physician. Rhonchi or whistles often preceded wheezes. Seventeen of the 20 patients with BHR completed 3 years of follow-up. Of these, 14 had recurrent episodes of wheezing and shortness of breath, and 3 were well. Six of the eight adenosine-negative patients completed 3 years of follow-up and had no symptoms of BHR. CONCLUSIONS: Acoustic BPT is a technically feasible test for the detection of BHR in young infants. CWD provides an earlier detection of wheeze than stethoscope auscultation. In our group of infants, a positive acoustic BPT result had high correlation with symptoms compatible with BHR over the next 3 years. 相似文献
49.
Ortiz-Alvarez O; Cabral D; Prendiville JS; Stringer D; Petty RE; Malleson PN 《Rheumatology (Oxford, England)》1997,36(2):280-284
Two children are reported in whom intestinal pseudo-obstruction was the
initial manifestation of systemic sclerosis. Gastrointestinal symptoms and
skin changes resolved or improved in both children following treatment with
prednisone and penicillamine (case 1) or methotrexate (case 2), although
radiological changes of the gastrointestinal tract persisted at 3 and 2 yr
of follow-up, respectively.
相似文献
50.
Campylobacter enteritis: clinical and epidemiologic features. 总被引:105,自引:0,他引:105
M J Blaser I D Berkowitz F M LaForce J Cravens L B Reller W L Wang 《Annals of internal medicine》1979,91(2):179-185
Campylobacter fetus subspecies (ssp.) jejuni has been recently recognized to cause diarrheal disease in man. To assess its importance as an enteric pathogen, we prospectively studied 514 patients with diarrhea. Campylobacter fetus ssp. jejuni was isolated from the feces of 26 patients (5%) and seven of 11 of their symptomatic household contacts. This organism was isolated from the feces of only one of 18 asymptomatic household contacts and not at all from 157 other healthy persons. Seventeen of 20 patients from whom C. fetus ssp. jejuni was isolated from fecal culture showed at least a fourfold rise in specific IgG titers. Review of 35 cases of campylobacter enteritis identified a typical clinical syndrome with acute onset of diarrhea, abdominal pain, fever, and constitutional symptoms. Stool examination revealed blood in 60% and polymorphonuclear leukocytes in 78% of patients. Epidemiologic investigation strongly suggested an external source for the infection in 22 of 35 patients. 相似文献